非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

The effect of physical fitness training on reaction time in youth with intellectual disabilities

The purpose of this study was to assess whether reaction time in persons with intellectual disabilities can be improved with an exercise program. 50 children and adolescents (M age = 14.7 yr., SD = 1.4, range = 11-18) with mild intellectual disability without Downs syndrome were randomly divided into control (20 boys, 5 girls) and experimental (19 boys, 6 girls) groups. The experimental group participated in a structured physical fitness program for 12 weeks. Reaction time was assessed at baseline and after 12 weeks. Significant improvements in reaction time were observed in the exercise group but not for the control group. Results indicated that reaction time can be improved with an exercise program in youth with intellectual disability.     

Parent’s Social Support for Children’s Outdoor Physical Activity: Do Weekdays and Weekends Matter?

In this study we examined the relationships among parental social supportive behaviors for children’s weekday and weekend outdoor physical activity (OPA). Thirty-nine girls and 29 boys 8 to 11 years wore pedometers for 7 days. Sixty-five mothers and 50 fathers responded to a social support questionnaire about OPA that was comprised of four dimensions: encouragement, playing with, use of activity as family recreation, and watch. After controlling for age and sport participation, regression analyses indicated that mothers’ use of activity as recreation was positively associated with girls’ weekday OPA. On the weekend, fathers’ play with son was positively related to OPA. The effectiveness of family-based activity interventions depends on when parents have opportunities to be present for their child’s activity and gender differences in the support provided.     

Effects of the Positive Action programme on problem behaviours in elementary school students: a matched-pair randomised control trial in Chicago

This study examined the effects of the Positive Action (PA) programme in Chicago Public Schools on problem behaviours among a cohort of elementary school students from grade three through grade five. Using a matched-pair, randomised control design with 14 elementary schools, approximately 510 fifth-graders self-reported lifetime substance use, serious violence-related behaviour, and current bullying and disruptive behaviours. Three-level (i.e. students nested within schools within school pairs) overdispersed Poisson models were used to examine programme effects on the number of items endorsed for each of the four outcomes. Findings indicated that students in the intervention endorsed 31% fewer substance use behaviours (incidence rate ratio [IRR] = 0.69), 37% fewer violence-related behaviours (IRR = 0.63) and 41% fewer bullying behaviours (IRR = 0.59), respectively, compared to students in the control schools. Reduction in reported disruptive behaviours was of a similar magnitude (27%, IRR = 0.73), but was not statistically significant. These results replicate findings of an earlier randomised trial of the PA programme and extend evidence of its effectiveness to youth attending large urban school systems.     

各种传统医学在高血压治疗中的应用

高血压痛作为最常见的慢性病,其并发症具有较高的致残率及致死率。本文综述近年来各种传统医学在高血压病治疗中的应用,包括传统中医对高血压痛的病因机的阐述,应用中药内服、外服、针灸等临床效果观察,蒙医辨证分型论治高血压病;藏医对高血压病的认识及临床采用的金针疗法治疗高血压病;壮医特色壮药内服,壮医药线点灸刺血疗法对高血压病的临床疗效评价。以此说明传统医药治疗方法对改善高血压病症状较明显,其治疗手段多样,副作用较小,降压效果平稳持久,有效减少并发症的优势。     

Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning

The corpus callosum (CC) is the largest white matter tract in the brain. It enables interhemispheric communication, particularly with respect to bimanual coordination. Here, we use diffusion tensor imaging (DTI) in healthy humans to determine the extent to which structural organization of subregions within the CC would predict how well subjects learn a novel bimanual task. A single DTI scan was taken prior to training. Participants then practiced a bimanual visuomotor task over the course of 2 wk, consisting of multiple coordination patterns. Findings revealed that the predictive power of fractional anisotropy (FA) was a function of CC subregion and practice. That is, FA of the anterior CC, which projects to the prefrontal cortex, predicted bimanual learning rather than the middle CC regions, which connect primary motor cortex. This correlation was specific in that FA correlated significantly with performance of the most difficult frequency ratios tested and not the innately preferred, isochronous frequency ratio. Moreover, the effect was only evident after training and not at initiation of practice. This is the first DTI study in healthy adults which demonstrates that white matter organization of the interhemispheric connections between the prefrontal structures is strongly correlated with motor learning capability.