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MM Roozendaal De Kruijf HF RJ Reuling A Threels JJ Swarts VM Wiegant JA Mattheij 《Stress (Amsterdam, Netherlands)》1997,1(4):241-248
There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge. 相似文献
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Dawn A. Laney Robin L. Bennett Virginia Clarke Angela Fox Robert J. Hopkin Jack Johnson Erin O’Rourke Katherine Sims Gerald Walter 《Journal of genetic counseling》2013,22(5):555-564
Identification and comprehensive care of individuals who have Fabry disease (FD) requires a multidisciplinary approach inclusive of genetic testing, test interpretation, genetic counseling, long term disease symptom monitoring, treatment recommendations, and coordination of therapy. The purpose of this document is to provide health care professionals with guidelines for testing, care coordination, identification of psychosocial issues, and to facilitate a better understanding of disease treatment expert recommendations for patients with Fabry disease. These recommendations are the opinions of a multicenter working group of genetic counselors, medical geneticists, and other health professionals with expertise in Fabry disease counseling, as well as representatives/founders of the two United States based Fabry disease patient advocacy groups who are themselves affected by Fabry disease. The recommendations are U.S. Preventive Task Force Class III, and they are based on clinical experience, a review of pertinent English-language articles, and reports of expert committees. This document reviews the genetics of Fabry disease, the indications for genetic testing, interpretation of results, psychosocial considerations, and references to professional and patient resources. 相似文献
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Phelps C Horrigan D Protheroe LK Hopkin J Jones W Murray A 《Journal of genetic counseling》2008,17(4):394-405
Many individuals receiving genetic counseling are healthy with no need for clinical cancer services. We have recently relocated
our cancer genetic clinic to a small house on the outskirts of a hospital site which incorporates many elements proven to
be important in creating a “well-being” environment. This study explored participants’ perceptions of such an environment.
Eleven semi-structured telephone interviews were conducted with women who had attended the new cancer genetic clinic. All
were at high risk of familial cancer, five were gene carriers and three had a personal diagnosis of cancer. The new clinic
was perceived to be less medical and more relaxing than other clinics, encouraged other family members to attend in support
of the attendee and did not appear to impede information comprehension. The importance of not being made to feel like an ill
patient was apparent. A desire for a quiet area allowing time for reflection whilst waiting for, and following, counseling
was identified. A poorly designed counseling area could reduce the quality of the interaction between patient and counselor.
Consideration of specific environmental design features may promote individuals’ well-being and make those attending genetic
counseling feel less like “patients.” Larger studies should seek to explore further the potential associations between factors
such as environmental design, psychological well-being and comprehension of risk information. 相似文献
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Media coverage of Direct-to-Consumer (DTC) genetic testing shapes public perception of such testing. The purpose of this study
was to determine and assess the themes presented by U.S. news media regarding DTC genetic testing. We performed a Lexis-Nexis
search with the keywords “Direct-to-Consumer” and “genetic test” for news stories published from 2006–2009. The sample was
coded on themes of genetic determinism, privacy, discrimination, validity, regulation, the Genetic Information Nondiscrimination
Act (GINA), utility, and cost. Ninety-two news stories were included. Stories displayed moderate genetic determinism and were
neutral about validity and utility. Stories indicated that insurance and employers were the most likely sources of discrimination,
yet identified the physicians and DTC companies as groups most likely to violate privacy. Stories claimed lack of regulation
would harm consumers, but most post-GINA stories did not discuss the law. The costs of tests were frequently included. The
results of this study show a broad range of views toward DTC genetic testing and its potential impacts. The genetics community
should be aware that the public has been exposed to multiple views of DTC genetic testing when discussing these tests. 相似文献
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