Continuity of personality patterning from 3 to 15 years in a longitudinal sample

A longitudinal sample of 97 subjects was rated at 3, 7, 11 and 15 years on variables selected as indices of Extraversion-Introversion (EI) and Neuroticism (N) or emotionality. Principal factor analysis and Varimax rotation were performed at each age. Continuity of patterning of the variables across the four ages was determined before, and after, rotation of the items to maximal contiguity by Kaiser's method. Two principal factors, clearly identifiable as EI and N, displayed very high continuity, as did 45 rotated factors, according to Gray's model. Four Varimax factors, which initially appeared dissimilar at different ages, were shown to display high continuity, in terms of loadings on standard reference axes, after alignment of the item vectors. Thus the inadequacy of simply comparing factors as they happen to emerge, was clearly demonstrated.     

Stability of individual differences in personality characteristics from 3 to 15 years

Ratings of 23 personality variables on a longitudinal sample of 97 children at the ages of 3, 7, 11 and 15 yr had previously been shown to yield orthogonal factors of high continuity of structure across ages. Subjects' scores on these factors were employed to derive stability coefficients over these ages. The general level of obtained r's is modest, but is higher for measures of Extraversion-Introversion (EI) and other broad factors (Neuroticism (N), Melancholic-Sanguine (MS), and Choleric-Phlegmatic (CP)) than for narrower Varimax factors (EI, Melancholic and Activity), except in the case of Choleric. Complete regression factor scores proved more satisfactory than an inexact method. Global ratings of EI and N yielded similar r's to the factor measures.The effects of correcting for rater unreliability and possible values of ‘protocol’ unreliability are examined. Even in the case of a maximal correction, stability tends to be lower than is found for IQ data, suggesting greater instability of the underlying personality variables.Lawley's test of heterogeneity of correlation matrices provides only limited evidence of a simplex pattern across ages, and virtually none of a ‘sleeper effect’. Jennrich's test of differences in matrices provides no evidence of sex differences in stability.Results on stability of the specific variables are also reported. They show, with few exceptions, lower stability than factor variables. Jennrich's test yielded significant sex differences on only three specific variables.     

Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory

Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory. It has been suggested that short-term recognition depends upon memory caused by the recent presentation of a stimulus that is independent of contextual-retrieval processes. The aim of the present set of experiments was to test whether the role of GluA1 extends to nonspatial recognition memory. Wild-type and GluA1 knockout mice were tested on the standard object recognition task and a context-independent recognition task that required recency-dependent memory. In a first set of experiments it was found that GluA1 deletion failed to impair performance on either of the object recognition or recency-dependent tasks. However, GluA1 knockout mice displayed increased levels of exploration of the objects in both the sample and test phases compared to controls. In contrast, when the time that GluA1 knockout mice spent exploring the objects was yoked to control mice during the sample phase, it was found that GluA1 deletion now impaired performance on both the object recognition and the recency-dependent tasks. GluA1 deletion failed to impair performance on a context-dependent recognition task regardless of whether object exposure in knockout mice was yoked to controls or not. These results demonstrate that GluA1 is necessary for nonspatial as well as spatial recognition memory and plays an important role in recency-dependent memory processes.     

Dementia with Lewy bodies: a pure case

A pure case of autopsy-confirmed dementia with Lewy bodies (DLB) is described. The patient presented with distinctive verbal fluency deficits in the context of mild language impairment, intact recognition memory, and impaired paragraph recall. Neuroimaging (CT and SPECT) showed progressive medial temporal lobe atrophy. Neuropathology revealed Lewy bodies, degeneration in the substantia nigra, nucleus basalis of Meynert (Nakano & Hirano, 1984), and locus ceruleus, but no pathology characteristic of Alzheimer's disease. It is in this sense that the case is "pure" DLB. Early neuropsychological diagnosis of DLB is essential (Salmon et al., 1996) given the potentially fatal hazard of neuroleptics (McKeith et al., 1992) and the difficulties associated with clinical neurological diagnoses (Litvan et al., 1998).     

Help‐Seeking for Suicidal Thoughts and Self‐Harm in Young People: A Systematic Review

There is a growing body of evidence to suggest that only a minority of young people experiencing suicidal thoughts or self‐harm present to any health services. This is of concern given that young people with suicidal thoughts or self‐harm often require treatment for mental illness as well as to reduce their risk of completed suicide. We reviewed previously published international community epidemiological studies examining help‐seeking for suicidal thoughts or self‐harm in young people up to the age of 26. The studies confirm that the majority of these young people do not seek professional help, and this includes seeking medical help after an overdose. The majority of young people studied do, however, seek help from social networks that most commonly are peers. Factors influencing and barriers to help‐seeking are discussed and highlight a need for further research into the role that peers and family play in the help‐seeking process for young people with suicidal thoughts or self‐harm.