The effect of prenatal hypoxia on brain development: short- and long-term consequences demonstrated in rodent models

Hypoxia (H) and hypoxia-ischemia (HI) are major causes of foetal brain damage with long-lasting behavioral implications. The effect of hypoxia has been widely studied in human and a variety of animal models. In the present review, we summarize the latest studies testing the behavioral outcomes following prenatal hypoxia/hypoxia-ischemia in rodent models. Delayed development of sensory and motor reflexes during the first postnatal month of rodent life was observed by various groups. Impairment of motor function, learning and memory was evident in the adult animals. Activation of the signaling leading to cell death was detected as early as three hours following H/HI. An increase in the counts of apoptotic cells appeared approximately three days after the insult and peaked about seven days later. Around 14-20 days following the H/HI, the amount of cell death observed in the tissue returned to its basal levels and cell loss was apparent in the brain tissue. The study of the molecular mechanism leading to brain damage in animal models following prenatal hypoxia adds valuable insight to our knowledge of the central events that account for the morphological and functional outcomes. This understanding provides the starting point for the development and improvement of efficient treatment and intervention strategies.     

Judaism and the Dialogue of Religion and Science: A Personal Journey

ABSTRACT

Through a personal narrative about my own entry into the field of science and religion, the essay reflects on the interplay of religion and science in Judaism. In addition to documenting my involvement with the dialogue of religion and science, the essay provides a brief historical overview of the interplay of the relationship between science and religion in the case of Judaism and considers diverse approaches toward technoscience among the main strands of Judaism today. The essay ends by recognizing the importance of science in Jewish intellectual history and the potential contribution of Judaism to the field of religion and science.     

Maintaining Successful Aging: The Role of Coping Patterns and Resources

One of the main challenges of aging societies is maintaining quality of life despite inevitable changes that occur in the lives of elderly people. This study examined the contribution of coping resources and coping patterns to successful aging among elderly persons following a decline in health and function. Data were collected from 262 elderly Israelis during two home interviews carried out at an interval of 12 months. Successful aging was assessed using a number of measures of subjective well-being. Predictive variables included change in health/functioning, coping resources, and coping patterns (proactive and reactive). Hierarchical regression analyses showed that the coping resources self-efficacy and social support and the proactive coping pattern of concrete planning positively predicted successful aging, while the proactive coping pattern deciding on preferences had a negative influence. These results indicate that elderly people have the ability to shape their quality of life in the presence of decline in health and functioning by using appropriate coping resources and coping patterns. Controlled interventions are recommended to help older people acquire and maintain effective resources and coping skills, thus further promoting their successful aging process.     

RETHINKING THE PAST AND ANTICIPATING THE FUTURE OF RELIGION AND SCIENCE

Abstract. John Caiazza presents the current technoculture as the latest development in the ongoing conflict of science and religion that began with Tertullian in the third century. I argue that his presentation is historically inaccurate, because for most of Western history science and religion interacted with and cross‐fertilized each other. Contrary to Caiazza's misleading presentation, Western thought did not follow the dichotomous model polemically posed by Tertullian. I take issue with Caiazza's portrayal of postmodernism and his claim that technology is the foundation of an inherently secularist culture. I conclude by highlighting certain ethical challenges engendered by the prevalence of new technologies and present the dialogue of science and religion as uniquely qualified to address these challenges.     

HISTORY AND THE FUTURE OF SCIENCE AND RELIGION

Philip Hefner identifies three settings in which to assess the future of science and religion: the academy, the public sphere, and the faith community. This essay argues that the discourse of science and religion could improve its standing within the secular academy in America by shifting the focus from theology to history. In the public sphere, the science‐and‐religion discourse could play an important role of promoting tolerance and respect toward the religious Other. For a given faith community (for example, Judaism) the discourse of science and religion can ensure future intellectual depth by virtue of study and ongoing interpretation. The essay challenges the suggestion to adopt irony as a desirable posture for science‐and‐religion discourse.