Behavioural state differentially engages septohippocampal cholinergic and GABAergic neurons in R6/1 Huntington's disease mice

Huntington's disease (HD) is a neurodegenerative condition characterised by progressive motor, psychological and cognitive decline. R6/1 HD transgenic mice model the clinical hippocampal-dependent cognitive deficits observed in patients. Cholinergic and GABAergic septohippocampal projections play important roles in hippocampal-dependent cognition. The current study examined neuronal activity of cholinergic and GABAergic septohippocampal projections in response to arousal elicited during differing behavioural states. The different behavioural states examined were; home cage (controls), acute exploration of a novel enriched environment and either spontaneous wakefulness (dark phase) or spontaneous sleep (light phase). We employed triple-label immunohistochemistry using c-Fos as an indirect marker of neuron activation and parvalbumin and choline acetyltransferase (ChAT) to label GABAergic and cholinergic neurons in the basal forebrain, respectively. The Y-maze was used to assess short-term hippocampal-dependent memory independently during either the dark or light phase and revealed a memory deficit in R6/1 HD mice compared to wild types that was particularly prominent during the dark phase. Three-way ANOVA of basal forebrain cholinergic and GABAergic activity through co-expression of c-Fos revealed overt responses to differing behavioural states. Both genotypes increased cholinergic neuron activity in response to exploring a novel enriched environment and also an increase during the dark phase compared to the light phase. Novel enriched environment exploration caused a larger response of GABAergic neuron activity in R6/1 HD mice, which also failed to increase the activity of GABAergic neurons during the dark phase compared to the light phase as observed for wildtype mice. Basal levels of c-Fos-positive cells were greatly increased in the hippocampal granule cell layer of R6/1 HD mice during both circadian phases. The differential activation of septohippocampal cholinergic and GABAergic neurons in R6/1 HD mice in response to differing behavioural states may be associated with impaired hippocampal-dependent short-term memory.     

Correlates of Career Satisfaction in Canada—the Immigrants’ Experience

This paper explores the correlates of career satisfaction among Canadian managers, professionals and executives, specifically the career satisfaction experience of both visible minority and non-visible minority immigrants. Survey data collected from over 13,000 managers, professionals and executives in 43 Canadian organizations were analysed using the ordinary least squares multiple regression technique. Results indicate that immigrants experience lower career satisfaction than native-borns and visible minority immigrants have lower career satisfaction than non-visible minority immigrants. Employee and employer characteristics, objective employment outcomes and subjective perceptual measures were found to be positively associated with career satisfaction for immigrant and native-born respondents.     

Group treatment for trichotillomania: behavior therapy versus supportive therapy

In this randomized controlled trial, group behavior therapy (BT; n = 12) was compared to group supportive therapy (ST; n = 12) in the treatment of trichotillomania (TTM). Both treatments were also compared to a naturally occurring waiting period, the time period that participants waited for groups to form. Participants completing group BT experienced significantly greater decreases in self-reported hair-pulling symptoms and clinician-rated hair loss severity than did those in group ST. Decreases were significantly greater after treatment than after the naturalistic waiting period. In addition, a significantly higher percentage of those in the BT than ST condition were rated as much improved or very much improved on the Clinical Global Impression scale at posttreatment. However, despite substantial symptom improvement, TTM severity remained problematic at posttreatment. Specifically, few participants in either treatment met criteria for clinically significant change at posttreatment. In addition, relapse of symptoms occurred over the 6-month follow-up period. Results provided partial support for the short-term efficacy of group BT. However, the group format may not maximize the efficacy of BT for TTM. Thus, it is recommended that future BT research test either individual therapy or a combination of group and individual formats for TTM.     

Addressing Psychometric Limitations of the Difficulties in Emotion Regulation Scale Through Item Modification

Through its frequent use, a pattern has emerged showing psychometric limitations of the Difficulties in Emotion Regulation Scale (DERS; Gratz &; Roemer, 2004 Gratz, K. L., &; Roemer, L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the Difficulties in Emotion Regulation Scale. Journal of Psychopathology and Behavioral Assessment, 26, 41–54.[Crossref], [Web of Science ®] , [Google Scholar]). This 3-part study sought to (a) determine whether these limitations are due to a method effect by rewording all reverse-coded items in a straightforward manner and submitting them to exploratory factor analysis (EFA), and (b) examine the tenability of an adaptation of the original measure. EFA results from Study 1 (N = 743) supported retention of 29 modified items across 5 factors. Consistent with the original theoretical underpinnings of the DERS, Awareness and Clarity items loaded on the same factor. In Study 2 (N = 738), confirmatory factor analysis (CFA) was used to examine the factor structure of the pool of items identified in Study 1. All of the modified subscales clustered strongly with one another and evidenced large loadings on a higher-order emotion regulation construct. These results were replicated in Study 3 (N = 918). Results from Study 3 also provided support for the reliability and validity of scores on the modified version of the DERS (i.e., internal consistency, convergent and criterion-related validity). These findings provide psychometric support for a modified version of the DERS.     

Are inductively derived categories of facial activity reliable when applied to high-risk infants tested before term age?

The techniques of facial coding employed with full-term infants have been applied to studies of premature infants tested before 40 weeks postconceptional age. The purpose of this research was to evaluate the methodological wisdom of using the coding strategies that were developed for older populations of infants with high-risk, premature infants who are tested while still in the hospital. As a first step, we tested the eight most commonly used categories of facial activity. The results were not encouraging; the meanr(β) was .61 and the mean κ was .52. On the basis of our assessment of the limitations in using these traditional facial categories, we developed six new categories of action. This time the results were more positive; the meanr(β) was .92 and the mean κ was .80. The new catalog appears to be a reliable representation of a range of facial behaviors observed in infants who are tested well before term age.     

Assessment of Trichotillomania: A Psychometric Evaluation of Hair-Pulling Scales

Currently there is no gold standard treatment outcome measure for trichotillomania (TTM), a disorder characterized by repetitive hair pulling resulting in noticeable hair loss. The goal of the current study was to evaluate the psychometric properties of TTM measures of differing assessment methods: self-report, clinician-rated summary scales, and clinician-rated global severity scales. Data collected from 28 patients with TTM indicated mixed psychometric properties for current scales. Internal consistency was strong for self-report but not clinician-rated summary scales. One clinician-rated summary scale total and subjective ratings of hair loss demonstrated good interrater agreement. Although convergent validity was good within measurement type, self-report did not correlate with clinician-rated global severity scales, perhaps because of absence of hair loss severity assessment on the self-report measure. A multimethod assessment including one of each type of measure reviewed in this paper, along with self-monitoring and measures of hair loss severity, is recommended for a comprehensive best practice approach to TTM assessment.     

Influence of parent,child, and contextual factors on the quality of the home environment

The purpose of this study was to examine factors related to the quality of the home environments mothers provide for their infants. Data from the National Longitudinal Survey of Youth on 602 mothers with infants between 12 and 23 months of age were used for this study. Consistent with Belsky's model of the determinants of parenting, the quality of the home environment was influenced by maternal characteristics, child characteristics, and contextual factors. A positive linear relation was found between scores on a family risk index and the probability that infants were experiencing a relatively unsupportive home environment.