阅读障碍的巨细胞系统缺陷理论之争

近几年诸多研究者认为阅读障碍是由于视觉系统巨细胞功能缺陷引起的。他们从对比度敏感性研究、巨细胞抑制功能研究与视觉运动知觉功能的研究结果中得到了支持证据。就这个问题的研究进行综述,表明不论是巨细胞功能缺陷理论的支持者还是反对者,都从巨细胞的对比度敏感性、视觉运动知觉与巨细胞抑制功能上得到了一些研究结果的支持。巨细胞功能缺陷理论的支持者还从阅读障碍的神经生理学研究和阅读的脑功能研究中得到了一些支持性的证据。新的研究结果揭示了巨细胞系统缺陷理论与阅读之间的关系以及巨细胞系统缺陷理论的应用价值。在巨细胞系统缺陷理论的进一步研究中,还需要统一实验方法与实验标准以获得更多的证据,同时需要有新的方法来有效区分小细胞系统与巨细胞系统     

Religion,Spirits, Human Agents and Healing: A Conceptual Understanding from a Sociocultural Study of Tehuledere Community,Northeastern Ethiopia

This paper explores the relationship among religion, spirits and healing in the Tehuledere community in the northeastern part of Ethiopia and focuses on how this knowledge can inform primary healthcare reform. The study employed qualitative ethnographic methods. Participatory observation, over a total of 5 months during the span of 1 year, was supplemented by focus group discussions (96 participants in 10 groups) and in-depth interviews (n = 20) conducted with key informants. Data were analyzed thematically using narrative strategies. The present study revealed that members of the study community perceive health, illness and healing as being given by God. Many of the Tehuledere people attribute illness to the wrath of supernatural forces. Healing is thought to be mitigated by divine assistance obtained through supplication and rituals and through the healing interventions of nature spirit actors. We found that the health, illnesses and healing were inextricably linked to religious and spiritual beliefs. Our findings suggest that religious and spiritual elements should be considered when drafting and implementing primary healthcare strategies for the study communities and similar environments and populations around the globe.

     

Use of ratings of perceived exertion to anticipate treadmill test termination in patients taking beta-blockers

This investigation identified a perceptually-based "warning zone" that can be used to anticipate termination of treadmill tests administered to individuals taking beta-blockers. The use of ratings of perceived exertion to anticipate test termination may be valuable given the attenuation of heart rate associated with the use of this class of medication. Sixteen men with coronary artery disease participated in this investigation. Ratings of perceived exertion (Borg 6-20 Scale) were estimated during the last 15 sec. of each minute of a progressively incremented treadmill test. Tests were terminated when participants indicated they were too fatigued to continue. The time-to-test termination was determined from the point that participants estimated a rating of 10, 11, 12, 13, 14, 15, 16, and 17 in order to determine the rating that was less than or equal to the time associated with a single exercise stage. A rating of 14 was associated with impending termination, which can be used as a "warning zone." The time to termination corresponding to a rating of 14 was 153.1 sec. (SD = 27.0). Participants exercised for 153.1 sec. (SE = 27.0) after estimating a rating of 14. Once a rating of 14 is reached, volitional test termination will occur before the next exercise stage is completed.     

Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience

Early life events have profound consequences. Our research demonstrates that the early life stress of neonatal isolation (1-h individual isolation on postnatal days 2-9) in rats has immediate and enduring neural and behavioral effects. Recently, we showed neonatal isolation impaired hippocampal-dependent context conditioned fear in adult rats. We now expand upon this finding to test whether neonatal isolation impairs performance in inhibitory avoidance and in the non-aversive, hippocampal-dependent object recognition task. In addition to assessments of hippocampal-dependent memory, we examined if neonatal isolation results in cellular alterations in the adult hippocampus. This was measured with antibodies that selectively label calpain-mediated spectrin breakdown product (BDP), a marker of cytoskeletal modification that can have neuronal consequences. Neonatally isolated male and female rats showed impaired performance in both memory tasks as well as elevated BDP levels in hippocampal immunoblot samples. In tissue sections stained for BDP, the cytoskeletal fragmentation was localized to pyramidal neurons and their proximal dendrites. Interestingly, the hippocampal samples also exhibited reduced staining for the postsynaptic marker, GluR1. Neonatal isolation may render those neurons involved in memory encoding to be vulnerable to calpain deregulation and synaptic compromise as shown previously with brain injury. Together with our prior research showing enhanced striatal-dependent learning and neurochemical responsivity, these results indicate that the early experience of neonatal isolation causes enduring yet opposing region-specific neural and behavioral alterations.     

Using Wordle in Addictions Education

The authors of this article present a creative teaching strategy which illustrates how Wordle can be used in the addiction courses in counselor education programs. Wordle creates a representation of text where the more frequently the word is used, the larger the word appears in the form of a “word-cloud.” This method of graphically using words can illustrate meaning, perception, and change.