非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

Relation of game location and experience on mood states

The study investigated relationships between game location, performers' experience, and mood states. 31 experienced collegiate soccer players completed the Brunel Mood Scale to assess anger, calmness, confusion, depression, fatigue, happiness, tension, and vigor before eight competitive games (four home and four away). Participants were categorized into Experienced and Less Experienced groups, based on the level of performance at which they played. Repeated-measures multivariate analyses of variance compared mean mood scores across location and experience, and follow-up univariate analyses suggested the increase in mood scores on Tension and decrease in scores on Calmness, Happiness, and Vigor between playing away and at home were significantly greater for Less experienced soccer players than Experienced players. Implications of these findings for the applied practitioner are discussed.     

Defining and Understanding Mental Toughness within Soccer

This study examined the frequency of observed prosocial and antisocial behaviors in soccer teams, age differences in observed behaviors and motivational variables, and whether motivational variables account for age differences in observed behaviors. Participants were 313 adolescent soccer players, recruited from three age groups: under 13, under 15, and under 17. Each age group was represented by eight teams. Players were filmed during a game and completed questionnaires after the game. Videotaped games were analyzed by two observers, who recorded behaviors for each team rather than each individual player; therefore, all data were analyzed only at the group level. Observed antisocial behaviors were more frequent than prosocial ones. Significant differences were also identified among the three age groups with the oldest group displaying more frequent antisocial and less frequent prosocial behaviors and perceiving a stronger performance climate and a weaker mastery climate in their team compared to the two younger groups. A series of ANCOVAs using motivational variables as covariates indicated that mastery climate followed by performance climate accounted for the largest decrease in the variance of both prosocial and antisocial behaviors attributed to the age group factor. The findings are discussed in terms of their implications for promoting fair play in sport.     

Using Psychological Skills Training to Develop Soccer Performance

The present study examined the effects of a soccer, midfielder-specific psychological skills intervention comprising relaxation, imagery and self-talk on position-specific performance measures. Using a multiple-baseline-across-individuals design, five participants had three per-formance subcomponents assessed across nine competitive matches. The results of the study indicated the position-specific intervention to enable at least small improvements on the three dependent variables for each participant. Social validation data indicated all participants to perceive the intervention as being successful and appropriate to their needs. The findings provide further evidence to suggest the efficacy of sport, and position-specific interventions. Suggestions for future research are provided.     

The relationship between collective efficacy and precompetitive affect in rugby players: testing Bandura's model of collective efficacy

This study extended research examining Bandura's (1997) proposed model of collective efficacy. Specifically, it examined the relationships between groups' collective efficacy and the precompetitive anxiety and affect they experienced. Prior to a competitive match 66 male Rugby Union footballers from 6 teams (2 university teams and 4 county league teams) completed a single-item measure of confidence in their team winning the forthcoming match, a 10-item measure of confidence in their team performing well in the forthcoming match, the modified Competitive State Anxiety Inventory-2, and the Positive and Negative Affect Schedule. Stepwise (forward) multiple regression analyses indicated that scores for collective efficacy accounted for only 6.3% of the variance in the intensities of cognitive state anxiety and only 22% of the variance in the positive affect experienced prior to the rugby match. The results indicate that concerns with the team's ability to win a match were associated with high cognitive state anxiety and that doubts regarding the team's ability to perform well were related to low positive affect. Given the magnitude of predicted variances, the findings seem to give some support to Bandura's proposal that the beliefs in collective efficacy of individuals engaged in a team task are related to precompetitive affective reactions and the experience of state anxiety.     

各种传统医学在高血压治疗中的应用

高血压痛作为最常见的慢性病,其并发症具有较高的致残率及致死率。本文综述近年来各种传统医学在高血压病治疗中的应用,包括传统中医对高血压痛的病因机的阐述,应用中药内服、外服、针灸等临床效果观察,蒙医辨证分型论治高血压病;藏医对高血压病的认识及临床采用的金针疗法治疗高血压病;壮医特色壮药内服,壮医药线点灸刺血疗法对高血压病的临床疗效评价。以此说明传统医药治疗方法对改善高血压病症状较明显,其治疗手段多样,副作用较小,降压效果平稳持久,有效减少并发症的优势。     

Warnings given to observers can eliminate order effects

ObjectivesThe aim of the study was to examine the impact of warnings on order effects in attributions of ability.MethodQualified soccer coaches (N = 146) rated the ability of two soccer players (a control and target player) each shown, on video, performing a passing task eight times. For the control player, all participants saw the same footage in the same order. For the target player, participants viewed the same footage with half viewing a declining (successful to unsuccessful) performance pattern and half viewing an ascending pattern. Additionally, coaches either received no warning of the danger of order effects, a warning prior to viewing any footage, a warning prior to viewing the target player or a warning prior to rating the target player.ResultsResults indicated that primacy effects were observed in the no warning condition and the warning prior to rating the target. However, when warnings were given prior to observing the target player no order effects were observed.ConclusionThe results indicate that order effects can be eliminated by warning observers of the phenomenon.