Stress-induced Fos-like Immunoreactivity in the Pons and the Medulla Oblongata of Rats

Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response.     

Play and emotional availability in young children with Down syndrome

This study investigates mother–child interaction and its associations with play in children with Down syndrome (DS). There is consensus that mother–child interaction during play represents an important determinant of typical children's play development. Concerning children with DS, few studies have investigated mother–child interaction in terms of the overall emotional quality of dyadic interaction and its effect on child play. A sample of 28 children with DS (M age = 3 years) took part in this study. In particular, we studied whether the presence of the mother in an interactional context affects the exploratory and symbolic play of children with DS and the interrelation between children's level of play and dyadic emotional availability. Children showed significantly more exploratory play during collaborative play with mothers than during solitary play. However, the maternal effect on child symbolic play was higher in children of highly sensitive mothers relative to children whose mothers showed lower sensitivity, the former displaying more symbolic play than the latter in collaborative play. Results offer some evidence that dyadic emotional availability and child play level are associated in children with DS, consistent with the hypothesis that dyadic interactions based on a healthy level of emotional involvement may lead to enhanced cognitive functioning.     

Temperament and behaviour problems in children: A multilevel analysis of cross-cultural differences

Early temperament attributes have been linked to emerging behaviour problems and significant long-term consequences; however, these relations are rarely examined cross-culturally. The present study addresses this gap, employing multilevel modelling to explain within- and between-culture variances with respect to temperament predicting a spectrum of behaviour problems across 14 nations from the Joint Effort Toddler Temperament Consortium (JETTC). A total of 865 children between 17 and 40 months, with approximately equal age distribution across this developmental period and about equivalent representation of genders, were recruited from 14 nations. Greater negative emotionality was associated with more internalizing problems, whereas higher surgency and effortful control predicted fewer internalizing difficulties. Controlling for age and gender, temperament explained significant within- and between-culture variances in internalizing and externalizing problems (at the broad-band and fine-grained levels), as well as sleep problems. For internalizing difficulties, temperament accounted for more between-culture variance. In contrast, for externalizing difficulties, temperament accounted more for how individuals within the same culture differed from their same-culture counterparts. The within-culture findings suggest universal patterns of temperament-problem relations, informing cultural adaptation of interventions; between-culture findings enhance understanding of the implications of the cultural niche for normative behaviour and adjustment.     

Performance of an Adapted Version of the Timed Up-and-Go Test in People with Cognitive Impairments

In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among groups. A cross-sectional study was conducted with 118 community-dwelling older adults divided in three groups: PC (n?=?40), MCI (n?=?40) and AD (n?=?38). The evaluation was composed by the adapted TUGT and cognitive assessment (Addenbrooke's Cognitive Examination and Frontal Assessment Battery). Only the cadence of TUGT presented significant difference between groups, specifically between AD versus MCI and PC groups. The main correlations were found between time of TUGT with fluency domain and global cognitive function, especially in the AD Group. The findings contribute to the understanding of how cognition interferes on functional mobility in older people with MCI and AD. The adapted TUGT is easy to perform in clinical practice and can be useful when assessing mobility in people with cognitive impairment.     

The chance project: Complex interventions with adolescent school drop-outs in Naples

Abstract

In this paper the authors describe their long experience, as psychoanalytically oriented psychotherapists, with an experimental school project with adolescent school drop-outs, a project that has been running in three deprived contexts of Naples. In the paper the structure of the psychological project supporting workers involved with these disruptive adolescents is analysed in detail along with the theoretical framework that lies behind it. The authors also give some illustrations that show the intense dynamics present in this field of work and some meaningful developments observed in the relationships and communications between adolescents and adults and in the group of peers.     

Mother-child emotional availability in ecological perspective: three countries, two regions, two genders

This study used a cross-national framework to examine country, region, and gender differences in emotional availability (EA), a prominent index of mutual socioemotional adaptation in the parent-child dyad. Altogether 220 Argentine, Italian, and U.S. mothers and their daughters and sons from both rural and metropolitan areas took part in home observations when the children were 20 months old. In terms of country, Italian mothers were more sensitive and optimally structuring, and Italian children were more responsive and involving, than Argentine and U.S. dyads. In terms of region, rural mothers were more intrusive than metropolitan mothers, and boys from metropolitan areas were more responsive than boys from rural areas. In terms of gender, mothers of girls were more sensitive and optimally structuring than mothers of boys, and daughters were more responsive and involving than sons. Understanding how country, region, and gender influence EA exposes forces that shape child development, parent-infant interaction, and family systems.     

Association Between Gait and Dual Task With Cognitive Domains in Older People With Cognitive Impairment

The authors investigated whether impaired gait and dual-task performances are associated with specific cognitive domains among older people with preserved cognition (PC), mild cognitive impairment (MCI), and mild Alzheimer's disease (AD). The sample comprised 40 older adults with PC, 40 with MCI, and 38 with mild AD. The assessment consisted of gait (measured by 10-m walk test and Timed Up and Go Test [TUGT]), dual task (measured by TUGT associated with a cognitive-motor task of calling a phone number), and cognition (domains of the Addenbrooke Cognitive Examination–Revised and Frontal Assessment Battery [FAB]). For data analysis, the Pearson product-moment correlation and the backward stepwise linear regression were conducted. Language, fluency, and visuospatial domains predicted the 10-m walk test measure specifically in PC, MCI, and AD groups. Only the visuospatial domain was independently associated with the TUGT measure in the MCI and AD groups. FAB score, language domain, and FAB score and fluency domain were the strongest predictors for the isolated cognitive-motor task measure in the PC, MCI, and AD groups, respectively. The visuospatial domain was independently associated with the dual-task test measure in all 3 groups. The study findings demonstrate the influence of specific cognitive domains in daily mobility tasks in people with different cognitive profiles.     

Maternal reports of adaptive behaviours in young children: urban–rural and gender comparisons in Italy and United States

We compared how 182 Italian and US American urban and rural firstborn 20‐month‐old girls and boys cope with the demands of their environment through their adaptive behaviours in everyday activities. Using the Vineland Adaptive Behaviour Scales, we collected maternal reports of children's communication, daily living, socialization, and motor skills. Three sets of main effects (and no interactions) emerged. With respect to country, Italian children scored higher than US American children in adaptive communication and motor skills. With respect to region, urban children showed higher adaptive motor skills than rural children, and rural children showed higher adaptive daily living skills than urban children. Finally, with respect to gender, girls scored higher on an adaptive behaviour composite as well as adaptive communication skills, but boys higher in adaptive motor skills. We set these country, region, and gender main effects in the context of a discussion of developing adaptive behaviours in young children. Copyright © 2005 John Wiley & Sons, Ltd.