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DS Jessop JA Douthwaite GL Conde SL Lightman CM Dayan MS Harbuz 《Stress (Amsterdam, Netherlands)》1997,2(2):133-144
Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis. 相似文献
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Translation responses to individual words were elicited from 48 English-Spanish-French trilinguals, who translated in six
directions at study and two directions at test. Patterns of translation response times and error rates at study reflected
the relative proficiency of the trilinguals in comprehension and production of their three languages. At test, repeated items
were translated more quickly than new items, with the strongest priming effects occurring for identical repetitions. Repetition
priming was also substantial when only the stimulus language or only the response language matched from study to test, implying
that repeated comprehension and production processes contribute to priming in translation. Patterns of response times and
repetition priming indicate that translation in all directions involved conceptual access. Additive patterns in response time
asymmetries and repetition priming were consistent with the treatment of word comprehension and production processes of translation
as independent. 相似文献
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