Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Employment rejection and acceptance letters and their unintended consequences on image,self-concept,and intentions

This paper demonstrates that the positiveness and negativeness of letters of acceptance and rejection from companies have an impact on company image, self-concept of recipient, and reported future intentions of potential recruits. The implication for employers writing letters of acceptance and rejection is that they should communicate with prospective recruits in a positive manner no matter what the letter's message. Positive rejection letters can mitigate effects of rejection and negative acceptance letters can impair the positiveness of acceptance.This research was partially supported by Grant #82037 from the Purdue Agricultural Research Station. Reprints should be addressed to Dr. Richard Feinberg, Department of Consumer Sciences and Retailing, Purdue University, 1262 Matthews Hall, West Lafayette, IN 47907-1262.     

Perceptions of personal control and conformity of vocational choice as correlates of vocational development

This study examined differences in vocational maturity of women across different levels of internal-external control and typical versus atypical vocational choice. It was predicted that internally controlled women would have higher vocational maturity scores than externally controlled women; women who make atypical vocational choices would have higher vocational maturity scores than women who make typical choices. Data from the Attitude Scale of Crites' Career Maturity Inventory, MacDonald and Tseng's I-E Scale, and dichotomized ratings of typical versus atypical vocational choice were obtained from 179 freshmen to senior female student volunteers in a large New England university. Analysis of variance indicated that internally controlled women had significantly higher vocational maturity than externally controlled women (p <. 01); no differences were found in vocational maturity between those making typical or atypical vocational choices; the lowest level of vocational maturity was found for externally controlled females making atypical vocational choices. Implications of these findings for counseling are discussed.     

Concurrent therapies: a model for collaboration between psychoanalysts and other therapists

Many psychoanalysts treat individuals who are simultaneously in couples therapy or whose partners are in individual therapy. If such cases stall, some analysts may seek consultation from a colleague, though most have accepted the tacit historical prohibition against communication between therapists treating members of the same family. Experience, however, suggests that a certain form of communication between such therapists can have a powerfully enhancing effect on the concurrent therapies. After a review of the literature, the advantages, disadvantages, and impediments to collaborative cross-communication are examined. A model is then presented for use in ongoing discussion between therapists, and is illustrated with two clinical examples. The proposed model centers on the transference-countertransference configurations within the therapeutic field, and serves as an organizer highlighting areas for discussion.     

The effect of commitment on relative left frontal cortical activity: tests of the action-based model of dissonance

The action-based model of dissonance and recent advances in neuroscience suggest that commitment to action should cause greater relative left frontal cortical activity. Two experiments were conducted in which electroencephalographic activity was recorded following commitment to action, operationalized with a perceived choice manipulation. Perceived high as compared to low choice to engage in the action, regardless of whether it was counterattitudinal or proattitudinal, caused greater relative left frontal cortical activity. Moreover, perceived high as compared to low choice caused attitudes to be more consistent with the action. These results broaden the theoretical reach of the action-based model by suggesting that similar neural and motivational processes are involved in attitudinal responses to counterattitudinal and proattitudinal commitments.     

Will you be there for me when things go right? Supportive responses to positive event disclosures

Close relationship partners often share successes and triumphs with one another, but this experience is rarely the focus of empirical study. In this study, 79 dating couples completed measures of relationship well-being and then participated in videotaped interactions in which they took turns discussing recent positive and negative events. Disclosers rated how understood, validated, and cared for they felt in each discussion, and outside observers coded responders' behavior. Both self-report data and observational codes showed that 2 months later, responses to positive event discussions were more closely related to relationship well-being and break-up than were responses to negative event discussions. The results are discussed in terms of the recurrent, but often overlooked, role that positive emotional exchanges play in building relationship resources.     

What you want (and do not want) affects what you see (and do not see): avoidance social goals and social events

Two studies examined the influence of approach and avoidance social goals on memory for and evaluation of ambiguous social information. Study 1 found that individual differences in avoidance social goals were associated with greater memory of negative information, negatively biased interpretation of ambiguous social cues, and a more pessimistic evaluation of social actors. Study 2 experimentally manipulated social goals and found that individuals high in avoidance social motivation remembered more negative information and expressed more dislike for a stranger in the avoidance condition than in the approach condition. Results suggest that avoidance social goals are associated with emphasizing potential threats when making sense of the social environment.     

Managerial Structuring of Work as a Moderator of the Machiavellianism and Job Performance Relationship

In this study, we addressed the effect of the perceived work environment structure, as initiated by the managerial superior, on the relationship between Machiavellianism and job performance of store managers in a retail setting. The results showed a significant effect for managers who perceived that their supervisors initiated a loose work environment structure. No effect was found for managers working in a highly structured environment.     

Locus of Control,Machiavellianism, and Managerial Job Performance

In this study, we examined the moderating effect of locus of control on the relationship between Machiavellianism and job performance of store managers in a retail setting. Our results indicated a significant moderating effect for managers who perceive that they have an external control orientation but not for managers with an internal control orientation.