Neurosteroids in the Hippocampus: Neuronal Plasticity and Memory

The hippocampus, which is critically involved in learning and memory processes, is known to be a target for the neuromodulatory actions of steroid hormones produced by the adrenal glands and gonads. Much of the work of B.S. McEwen and collaborators has focused on the role of glucocorticosteroids and estrogen in modulating hippocampal plasticity and functions. In addition to hormones derived from the endocrine glands, cells in the hippocampus may be exposed to locally synthesized neurosteroids, including pregnenolone, dehydroepiandrosterone and their sulfated esters as well as progesterone and its reduced metabolites. In contrast to hormones derived from the circulation, neurosteroids have paracrine and/or autocrine activities. In the hippocampus, they have been shown to have trophic effects on neurons and glial cells and to modulate the activity of a variety of neurotransmitter receptors and ion channels, including type A gamma-aminobutyric acid, N-methyl-D-aspartate and sigma receptors and N- and L-type Ca2+ channels. There is accumulating evidence that some neurosteroids, in particular pregnenolone sulfate, have strong influences on learning and memory processes, most likely by regulating neurotransmission in the hippocampus. However, the hippocampus is not the only target for the mnesic effects of neurosteroids. Associated brain regions, the basal nuclei of the forebrain and the amygdaloid complex, are also involved. Some neurosteroids may thus be beneficial for treating age- or disease-related cognitive impairments.     

Adolescent Adjustment to Parental Divorce: An Investigation from the Perspective of Basic Dimensions of Structural Family Therapy Theory

This study, conducted within the framework of concepts of structural family therapy, examined the relationship of four family-based, clinical dimensions to the adjustment of 45 adolescents during the first 18 months of parental separation. There were two samples of mother-custody families: an Aided group that applied for treatment, and an Unaided group of paid volunteers. The inclusion of this variable addressed a major methodological deficit of previous studies. There was a significant association between perceived postseparation family structure and adolescent adjustment, demonstrating that individual adolescent adjustment is contingent on structural features of the contemporary postseparation family. Further, Aided families were perceived as more chaotic, disengaged, and enmeshed than Unaided families, while Aided adolescents were characterized by more behavior problems than Unaided adolescents. This suggests that divorce, as an unscheduled transition, might be within the realm of adaptation for many families and adolescents and is not necessarily "disastrous."     

Doctor Communication Style and Patient Outcomes: Gender and Age as Moderators

Past research has demonstrated that physicians' communication styles influence patient satisfaction, loyalty, recall of medical advice, and adherence to this advice. However, the research has failed to identify coherent interactional styles that produce favorable outcomes along all dimensions. The present study used a videotape analogue method to compare the efficacy of two communication styles that vary in terms of the power relations between the parties. Community members adopted the role of the patient and rated a male or female "doctor" using either an authoritative or a consultative communication style. Results indicate that the consultative style yielded superior satisfaction ratings, but not greater recall or adherence. The effects for style were moderated by significant interactions with physician gender and patient age.     

PHILOSOPHY AS TRAGEDY OR WHAT WORDS WON'T GIVE

This article examines Cavell's problematic understanding of scepticism and the knowledge of other minds with respect to his long preoccupation with tragedy. I point to the meta‐philosophical questions Cavell continually raises but fails to address such that a philosophy as tragedy is frequently announced. Taking the same meta‐philosophical questions raised by the inability of words to give us access to certain knowledge, I then rethink this problematic theologically. I show the way Cavell hints at a Christology and a doctrine of analogy neither of which he develops. In developing these two theologoumenon I make some observations on the relationship between theology, philosophy and the endemic potential of the tragic.