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MM Roozendaal De Kruijf HF RJ Reuling A Threels JJ Swarts VM Wiegant JA Mattheij 《Stress (Amsterdam, Netherlands)》1997,1(4):241-248
There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge. 相似文献
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MARTHA I. GIBSON 《Philosophy and phenomenological research》2008,76(1):215-219
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KEVIN GIBSON 《Journal of applied philosophy》1989,6(2):209-214
ABSTRACT This article is a response to Nani Ranken's paper 'Morality in business: disharmony and its consequences' ( Journal of Applied Philosophy , Vol. 4, p. 41). There she attacked the analogy sometimes made between businesses and persons, and concluded that businesses cannot be regarded as moral agents. Her thesis relies centrally on a very strict notion of a person's 'true good'. By exploring and expanding the concepts of 'true good' and 'moral agency' we are able to recover a sense in which businesses are indeed members of the moral community. Moreover, admitting businesses to the moral community also provides a working framework to examine the claim that what is good for business is in harmony with the dictates of morality. 相似文献
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