Understanding of Genetic Inheritance among Xhosa-Speaking Caretakers of Children with Hemophilia

Hemophilia A and B are X-linked recessive inherited bleeding disorders that have a profound impact on the family of affected individuals. Education is vital to enable women to appreciate the implications of being a carrier and the implications for a prospective child. Prior research has shown that cultural, socio-economic and linguistic issues in South Africa are major barriers to communication for first-language Xhosa-speakers. This exploratory study aimed to investigate the basic knowledge of genetic inheritance among this cultural group in order to promote culturally-sensitive, effective genetic counseling. Ten in-depth interviews were conducted with Xhosa-speaking mothers or caregivers of boys with hemophilia. Results suggest that the participants had a very limited understanding of the clinical management, genetic consequences and cause of hemophilia. While treatment and care by health care service providers was fully accepted, several participants believed that traditional methods would provide them with more satisfactory explanations. These findings suggest that there is a critical need for socio-culturally tailored, language-specific education for families with hemophilia.     

The Death of Socrates

Abstract

In Phaedo, Plato shows the grace of a true courage which can affirm life even in death. Socrates’ courage is not that of the martyr, grounded on a belief in divine reward; his is the courage of the philosopher who knows that he does not know. In his self-reflexive striving to be a person who strives for wisdom, Socrates dissipates the fear of death by dissolving the presumption on which this fear is based, and reframing death as an opportunity for knowledge. Socrates’ courage is therefore founded on an epistemic hope that is embodied in the very activity of philosophy.     

The discrimination of natural movement by budgerigars (Melopsittacus undulates) and pigeons (Columba livia)

Three experiments examined the ability of birds to discriminate between the actions of walking forwards and backwards as demonstrated by video clips of a human walking a dog. Experiment 1 revealed that budgerigars (Melopsittacus undulates) could discriminate between these actions when the demonstrators moved consistently from left to right. Test trials then revealed that the discrimination transferred, without additional training, to clips of the demonstrators moving from right to left. Experiment 2 replicated the findings from Experiment 1 except that the demonstrators walked as if on a treadmill in the center of the display screen. The results from the first 2 experiments were replicated with pigeons in Experiment 3. The results cannot be explained if it is assumed that animals rely on static cues, such as those derived from individual postures, in order to discriminate between the actions of another animal. Instead, this type of discrimination appears to be controlled by dynamic cues derived from changes in the posture of the demonstrators.     

Revisiting places passed: sensitization of exploratory activity in rats with hippocampal lesions

We examined the involvement of the hippocampus in short-term changes in exploratory behaviour in an open field (Experiment 1) and experimental contexts (Experiment 2). In Experiment 1, rats with excitotoxic lesions of the hippocampus were more likely to revisit recently visited zones within the open field than were control rats. Similarly, in Experiment 2 rats with hippocampal lesions showed greater exploration of a context that they had recently explored than a context that they had less recently explored. This short-term sensitization effect was not evident in control rats. These findings are consistent with the suggestion that the recent presentation of a stimulus has two opposing effects on behaviour, sensitization, and habituation, and that hippocampal lesions disrupt the short-term process responsible for habituation, but not that responsible for sensitization.     

Variations in Philosophical Genre: the Platonic Dialogue

The primary function of the Platonic dialogue is not the communication of philosophical doctrines but the transformation of the reader's character. This article takes up the question of how, or by what means, the Platonic dialogue accomplishes its transformative goal. An answer is developed as follows. First, the style of reading associated with analytical philosophy is not transformative, on account of its hermeneutical attachment and epistemic equality in the relationship between reader and author. Secondly, the style of reading associated with the genre of commentary is transformative because it is governed by a principle of authority. When the commentary model is applied to the Platonic dialogue, it can be seen that the dialogue mimics the function of the authority principle in transforming the reader into a commentator, that is, someone who reads from a position of detachment and accepts responsibility for himself as moral and epistemic agent.     

Philosophical Anti-authoritarianism

Philosophia - Unlike certain commentary traditions of philosophy in which deference to an authoritative author was a central feature, there are within the analytical tradition no recognised...     

Socrates,Crito, and emigration from South Africa

This article uses Plato’s Crito as a lens through which to consider the question of whether a South African citizen should emigrate from South Africa. While this question is not exactly parallel to that of whether the condemned Socrates should flee Athens, it has much more to do with justice than is commonly thought. For in order for one to know whether one has an overall duty to remain in or leave South Africa, one must determine what one owes to one’s country and compatriots, one’s community, one’s family, and oneself.     

How rats perform spatial working memory tasks: limitations in the use of egocentric and idiothetic working memory

Rats of the Dark Agouti strain were trained on delayed alternation under conditions that should encourage egocentric working memory. In two experiments a T-maze was set within a cross-maze so that different arms could be used for the sample and test runs. The maze had high opaque side-walls, and testing was conducted in low light levels so that distal visual cues might be eliminated. By rotating the maze 90° between the sample and choice run and by using two identical mazes set side by side it was possible to nullify other spatial strategies. Experiments 1 and 2 showed that rats preferentially used place information, intramaze cues, and direction cues, even though only egocentric or idiothetic (nonmatch-to-turn) working memory could successfully solve every trial. Rats were able to maintain an accurate sense of location within the maze even though distal cues were not visible and the animal was moved between the sample and choice runs. Experiment 2 confirmed that another rat strain (Long-Evans) shows the same learning profiles. Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory.     

On Irony Interpretation: Socratic Method in Plato's Euthyphro

Socratic Method in the Euthyphro can be fruitfully analysed as a method of irony interpretation. Socrates' method – the irony of irony interpretation – is to pretend that Euthyphro is an ironist in order to transform him into a self-ironist. To be a self-ironist is to ironize one's knowledge of virtue in order to bring an intuitive and unarticulated awareness of virtue to mind. The exercise of the capacity for self-irony is then a mode of striving for the good.     

A Mobile Colonoscopic Unit for Lynch Syndrome: Trends in Surveillance Uptake and Patient Experiences of Screening in a Developing Country

The Genetic and Endoscopic Surveillance Clinic is an annual outreach service offering accessible colonoscopic surveillance to known families with Lynch syndrome living in remote areas of the Western and Northern Cape Province of South Africa. Unfortunately attendance at this outreach clinic has been declining over several years and fewer than a quarter of participants, attending for surveillance, have been adherent with all their recommended screening appointments. Concerns exist for non-adherent individuals as screening can prevent colorectal cancer by removing the precancerous lesion or enabling the treatment of a malignancy at an early stage. This study explored the experience of surveillance from both the non-adherers’ and adherers’ perspectives and identified unique factors affecting attendance at the outreach clinic. Rates of compliance are calculated for 191 mutation-positive cases of Lynch syndrome, using strict attendance criteria, and compared to figures obtained from self-reported attendance. Non-compliance was under-reported and compliance was exaggerated when basing data on self-reported adherence to recommendations. Specific characteristics of the outreach clinic affecting compliance are identified and recommendations are made to facilitate improvements to the service. These improvements can result in increased compliance with screening regimens and ultimately reduce cancer-related mortality.