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11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. In rats, chronic glucocorticoid excess or stress increases 11beta-HSD-1 in the hippocampus, producing suggestions that it may attenuate the deleterious effects of chronic glucocorticoid excess. However, 11beta-HSD-1 predominantly catalyses 11beta-reduction in the intact liver and hippocampal cells, thus regenerating active glucocorticoids from inert substrate. We studied 11beta-HSD activity in the tissues of male tree shrews following 28 days of sustained psychosocial stress or exogenous administration of cortisol. In the hippocampus, chronic psychosocial stress attenuated 11-HSD-1 activity (69 +/- 9% of control), whereas cortisol alone had no effect. In the liver, both chronic stress and cortisol administration decreased 11beta-HSD-1 activity (47 +/- 11% and 49 +/- 4% fall, resp.). Attenuation of 11beta-HSD-1 within tissues may reflect a homeostatic mechanism designed to minimise the adverse effects of prolonged stress and/or glucocorticoid excess. 相似文献
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Albert Bandura Bill Underwood Michael E. Fromson 《Journal of research in personality》1975,9(4):253-269
The present study tested derivations from social learning theory on the disinhibition of aggression through processes that weaken self-deterring consequences to injurious conduct. Subjects were provided with opportunities to behave punitively under diffused or personalized responsibility toward groups that were characterized in either humanized, neutral, or dehumanized terms. Both dehumanization and lessened personal responsibility enhanced aggressiveness, with dehumanization serving as the more potent disinhibitor. Escalation of aggression under conditions of dehumanization was especially marked when punitiveness was dysfunctional in effecting desired changes. The uniformly low level of aggression directed toward humanized groups, regardless of variations in responsibility and instrumentality of the conduct, attested to the power of humanization to counteract punitiveness. Results of supplementary measures are consistent with the postulated relationship between self-disinhibiting processes and punitiveness. Dehumanization fostered self-absolving justifications that were in turn associated with increased punitiveness. Findings on the internal concomitants of behavior performed under different levels of responsibility suggest that reducing personal responsibility heightens aggressiveness more through social than personal sources of disinhibition. 相似文献
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Julie Cerel PhD Jason H. Padgett MSM‐PM Gerald A. Reed PhD MSW 《Suicide & life-threatening behavior》2009,39(6):588-598
To update and expand Rubey and McIntosh's (1996) survivors of suicide support groups report, SPAN USA completed a survey of U.S. support group leaders (n = 100; 24% completion). There are now more survivor groups (from 280 to 417), and the majority of groups now have a survivor leader (78% vs. 25%). Groups continue to be small (88% < 10 members per session) and meet on a monthly basis (55%). Sharing continues to be a universal experience in groups, which tend to be open‐ended (85%). Current groups are newer, and more operate without a sponsor. Further research is needed to examine group member perspectives and effectiveness of groups. 相似文献
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In this article, the concept of “media lifestyles” is adopted in order to develop a comprehensive approach toward youth engagement in communication media. We explore how 503 Dutch eighth grade students with full access to new technology combine a broad range of media by focusing on their engagement with media while taking various contexts of use into account. Four different media lifestyles of media omnivores, networkers, gamers, and low‐frequency users are described. Furthermore, we show how the methodology we used is able to provide more insight into how the distinguished media lifestyles were codetermined by particular media, functions and social contexts. Finally, the implications for the Uses & Gratifications theory are discussed. 相似文献
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Fromson PM 《Psychological reports》2006,98(1):99-105
Self-discrepancy theory associates shame with deviations from ideals that significant others hold for us and guilt with deviations from one's own moral guides. By contrast, Tangney posits that, although transgressions may engender both of these emotions, the nature of focus determines the specific reaction. Focusing upon the action committed engenders guilt, whereas focusing on the self who committed the action engenders shame. Participants recounted one of four types of discrepant actions and responded to measures of shame, guilt, anxiety, and depression. Consistent with Tangney's theorizing, across all types of discrepant actions, guilt was rated significantly higher than shame. 相似文献
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