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Dr. Ruth L. Fischbach Ph.D. Diane C. Gilbert C.R.A. 《Science and engineering ethics》1995,1(4):389-402
We propose that institutions consider establishing a position of “Ombudsman for Research Practice”. This person would assume several roles: as asounding board to those needing confidential consultation about research issues — basic, applied or clinical; as afacilitator for those wishing to pursue a formal grievance process; and as aneducator to distribute guidelines and standards, to raise the consciousness regarding sloppy or irregular practices in order to prevent misconduct and to promote the responsible conduct of research. While there are compelling features to this position, many complex issues need to be considered and resolved. We invite readers to respond to questions we raise in the text. 相似文献
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I L Ward J E Franck W R Crowley 《Journal of comparative psychology (Washington, D.C. : 1983)》1977,91(6):1416-1423
Progesterone induced high levels of female lordotic behavior in 10 of 17 intact, estrogen-primed male rats when it was applied directly to the medial preoptic-anterior hypothalamic area. All 17 males previously had shown lordosis when the serotonergic antagonist methysergide was applied to the same central sites. Few males responded to systemic progesterone and none to intracralial cholesterol. Intradiencephalic Metycaine, a local anesthetic, induced lordosis in eight male that previously had responded to central progesterone. These data indicate that estrogen and progesterone act synergistically to induce lordosis in male rats when progesterone is administered directly to sensitive brain sites. 相似文献
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Mood-congruent attentional bias in dysphoria: maintained attention to and impaired disengagement from negative information 总被引:1,自引:0,他引:1
Attentional bias to negative information has been proposed to be a cognitive vulnerability factor for the development of depression. In 2 experiments, the authors examined mood-congruent attentional bias in dysphoria. In both experiments, dysphoric and nondysphoric participants performed an attentional task with negative, positive, and neutral word cues preceding a target. Targets appeared either at the same or at the opposite location of the cue. Overall, results indicate that dysphoric participants show maintained attention for negative words at longer stimulus presentations, which is probably caused by impaired attentional disengagement from negative words. Furthermore, nondysphoric participants maintain their attention more strongly to positive words. These results are discussed in relation to recent developments in the pathogenesis and treatment of depression. 相似文献
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Dorothée?LegrandEmail author Franck?Grammont 《Phenomenology and the Cognitive Sciences》2005,4(3):249-257
We discuss the justification of Bickle's “ruthless” reductionism. Bickle intends to show that we know enough about neurons
to draw conclusions about the “whole” brain and about the mind. However, his reductionism does not take into account the complexity
of the nervous system and the fact that new properties emerge at each significant level of integration from the coupled functioning
of elementary components. From a methodological point of view, we argue that neuronal and cognitive models have to exert a
mutual constraint(MC) on each other. This approach would refuse to award any priority of cognitive approaches over neuroscience, and reciprocally,
to refuse any priority of neuroscience over cognitive approaches. MC thus argues against radicalreductionism at the methodological level. 相似文献
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Calcium signaling in mitral cell dendrites of olfactory bulbs of neonatal rats and mice during olfactory nerve Stimulation and beta-adrenoceptor activation
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Yuan Q Mutoh H Debarbieux F Knöpfel T 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(4):406-411
Synapses formed by the olfactory nerve (ON) provide the source of excitatory synaptic input onto mitral cells (MC) in the olfactory bulb. These synapses, which relay odor-specific inputs, are confined to the distally tufted single primary dendrites of MCs, the first stage of central olfactory processing. beta-adrenergic modulation of electrical and chemical signaling at these synapses may be involved in early odor preference learning. To investigate this possibility, we combined electrophysiological recordings with calcium imaging in olfactory bulb slices prepared from neonatal rats and mice. Activation of ON-MC synapses induced postsynaptic potentials, which were associated with large postsynaptic calcium transients. Neither electrical nor calcium responses were affected by beta-adrenergic agonists or antagonist. Immunocytochemical analysis of MCs and their tufted dendrites revealed clear immunoreactivity with antibodies against alpha1A (Cav2.1, P/Q-type) and alpha1B (Cav2.2, N-type), but not against alpha1C (Cav1.2, L-type) or alpha1D (Cav1.3, L-type) calcium channel subunits. Moreover, nimodipine, a blocker of L-type calcium channels, had no effect on either electrical or calcium signaling at ON-MC synapses. In contrast to previous evidence, we concluded that in neonatal rats and mice (P5-P8), mitral cells do not express significant amounts of L-type calcium channels, the calcium channel type that is often targeted by beta-adrenergic modulation. The absence of beta-adrenergic modulation on either electrical or calcium signaling at ON-MC synapses of neonatal rats and mice excludes the involvement of this mechanism in early odor preference learning. 相似文献
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The present study examined the perceptions school-age children have of stutterers. Four groups of fourth and fifth grade students viewed a videotape with either the speaker stuttering or not stuttering while reading a poem. A semantic differential scale of bi-polar adjective pairs was used to rate the speaker on intelligence and personality traits. The current study found that there is a significant difference between school-age children's perceptions of stutterers and nonstutterers with the ratings for the disfluent speaker more negative than the ratings for the fluent speaker. It was found that children did not rate personality and intelligence related traits differently. This information can be used to validate the need for education regarding stuttering for children and those who work with children. EDUCATIONAL OBJECTIVES: The reader will learn about and be able to (1). identify perceptions of stutterers by a variety of groups; (2). discuss the implications of research on perceptions of stutterers; and (3). compare/contrast children and adults and their perceptions. 相似文献
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This paper links experimental psycholinguistics and theoretical syntax in the study of subject-verb agreement. Three experiments of elicited spoken production making use of specific characteristics of Italian and French are presented. They manipulate and examine its impact on the occurrence of 'attraction' errors (i.e. incorrect agreement with a word that is not the subject of the sentence). Experiment 1 (in Italian) shows that subject modifiers do not trigger attraction errors in free inverted VS (Verb Subject) structures, although attraction was found in VS interrogatives in English (Vigliocco, G., & Nicol, J. (1998). Separating hierarchical relations and word order in language production. Is proximity concord syntactic or linear? Cognition, 13-29) In Experiment 2 (in French), we report stronger attraction with preverbal clitic object pronouns than with subject modifiers. Experiment 3 (in French) shows that displaced direct objects in the cleft construction trigger attraction effects, in spite of the fact that the object does not intervene between the subject and the verb in the surface word order (OSV). Moreover, attraction is stronger in structures with subject-verb inversion (...). These observations are shown to be naturally interpretable through the tools of formal syntax, as elaborated within the Principles and Parameters/Minimalist tradition. Three important constructs are discussed: (1) the hierarchical representation of the sentence during syntactic construction, and the role of intermediate positions by which words transit when they move; (2) the role of specific hierarchical (c-command) but also linear (precedence) relations; and (3) the possibility that agreement involves two functionally distinct components. A gradient of computational complexity in agreement is presented which relates empirical evidence to these theoretical constructs. 相似文献
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Judith Giencke Kimball Caryn T. Birstler Erica Franck Bosse Lisa M. Nelson Mark R. Woods 《Occupational Therapy in Mental Health》2013,29(1):72-87
The purpose of the authors in this study is to explore the possible relationships among sensory processing styles, possible sensory processing disorders, personality traits, and body mass index. There is research on the relationship between obesity as defined by body mass index and temperament, and sensory processing and temperament; however, no information could be found on the relationship between body mass index and sensory processing styles, or the role that temperament and personality styles may play in these relationships. The 50 female participants were recruited from the University of New England community. The sample included women between the ages of 19 and 59 years, and of various weights. None of the participants had a history of thyroid problems, diabetes, or any physical disabilities that would limit daily physical activity. None had been diagnosed with sensory processing disorder. All participants filled out two self-reports and a demographic questionnaire. The Adult/Adolescent Sensory Profile (Brown &; Dunn, 2002) determines a person's sensory processing style and possible sensory processing disorder, and the Basic Personality Inventory (Jackson, 1996) focuses on everyday behaviors to describe temperament and “adult behavioral syndromes” (p. 5). Through this study the authors show only tentative relationships between body mass index and sensory processing styles and personality traits. The data could be interpreted to support both discriminant and convergent validity between the Adult/Adolescent Sensory Profile and the Basic Personality Inventory. There were, however, significant correlations between aspects of sensory processing and aspects of personality that appeared to strengthen the idea that differences in sensory processing result in predictable types of behavior, indicating that sensory processing disorders are a separate diagnostic category. 相似文献
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