Naturally occurring language as a source of evidence in suicide prevention

We discuss computational language analysis as it pertains to suicide prevention research, with an emphasis on providing non‐technologists with an understanding of key issues and, equally important, considering its relation to the broader enterprise of suicide prevention. Our emphasis here is on naturally occurring language in social media, motivated by its non‐intrusive ability to yield high‐value information that in the past has been largely unavailable to clinicians.     

Inequalities of power and sexual problems

The proposition that sexual problems can emerge as a response to structural inequalities of power is explored by reference to a case which forms part of our current clinical work and research in this area. It is suggested that inequalities of power between heterosexual partners and societal 'discourses' which support the use of sexuality, predominantly by women, as an influence strategy, can serve to promote the development and maintenance of sexual symptoms as forms of covert power struggles. An integration is attempted of systemic and feminist theories with some practical suggestions for therapists working with couples with sexual problems.     

Heart rate--QT relationships during baroreceptor stimulation with diminished autonomic influence on the ventricles. Ventricular autonomic tone and QT interval.

The shortening of the QT interval of the electrocardiogram coincident with acceleration of heart rate and vice versa has been accepted for many years as evidence that the action potential duration and hence QT are necessarily dependent on heart rate. Exceptions to this rule have been attributed to the intervention of counteracting autonomic effects. In order to test this assumption, 26 conscious dogs divided into three groups were tested during baroreceptor stimulation by a bolus injection of phenylephrine. Seventeen dogs had been used in earlier studies in which they had undergone an experimental anterior myocardial infarction with apparent full recovery. A group of those dogs underwent beta-adrenergic blockade by intravenous atenolol 30 min prior to the baroreceptor activation. To test the intactness of the baroreceptor responses in the previously infarcted dogs, a third group of nine dogs that had had no prior myocardial infarction was included. All dogs were adapted to the laboratory environment and were not sedated during experiments. Simultaneous recordings of RR, QT interval, and phasic arterial pressure were made in all dogs before and during baroreceptor stimulation. In the normal group, and the previously infarcted group that received no atenolol, baroreceptor stimulation elicited a small (8/msec), but significant prolongation of the QT associated with a nearly 50% reduction in heart rate. The QT interval of the atenolol-treated dogs, although significantly more prolonged before stimulation, remained unchanged during the reflex. The data indicate that withdrawal of ventricular sympathetic tone may prolong the QT interval, thereby confirming the role of sympathetic innervation in the control of QT.(ABSTRACT TRUNCATED AT 250 WORDS)     

Roles of gonadotropins and releasing hormones in hypothalamic control of lordotic behavior in ovariectomized, estrogen-primed rats.

Intrahypothalamic effects of gonadotropins (luteinizing hormone and follicle-stimulating hormone), thyrotropin-releasing hormone (TRH), and luteinizing-hormone-releasing hormone (LRH) on lordotic behavior were evaluated in ovariectomized (OVX) rats maintained at different receptivity levels. Under conditions of low receptivity in which LRH has been shown to enchance mating behavior, medial preoptic area (MPOA) infusions of luteinizing hormone (LH) caused significant depressions in the lordotic response, whereas LH infusions into the arcuate ventromedial area (ARC-VM) had no sigificant effect. Follicle-stimulating hormone (FSH) infusions into either area did not alter the behavioral response. In the second experiment, in which OVX rats were primed with higher doses of estrone to maintain high ptrinfusion receptivity, MPOA or ARC-VM infusions of either LH or TRH were shown to depress lordotic behavior significantly, whereas neither LRH nor FSH was observed to inhibit the behavioral response. A third experiment evaluated the effects of LH, FSH, and TRH on LRH-facilitated mating behavior. Infusions of LRH into either the MPOA or the ARC-VM significantly enhanced mating behavior, whereas the addition of either TRH or LH to the LRH infusates abolished this response. The addition of FSH to LRH infusates neither enhanced nor depressed the behavioral response to MPOA or ARC-VM infusions of LRH. The antagonistic effects of LH and TRH on LRH-facilitated mating behavior were correlated with previous observations of antagonistic effects on hypothalamic unit activity and monoamine metabolism. The antagonistic interrelation between LRH and LH may represent a mechanism for the activation and coordination of sexual receptivity with ovulation.     

An Agent-Centered Account of Rightness: The Importance of a Good Attitude

This paper provides a sketch of an agent-centered way of understanding and answering the question, “What’s wrong with that?” On this view, what lies at the bottom of judgments of wrongness is a bad attitude; when someone does something wrong, she does something that expresses a bad, or inappropriate, attitude (where inappropriateness is understood, tentatively, as a failure to recognize the separateness of others). In order to motivate this account, a general Kantian agent-centered ethics is discussed, as well as Michael Slote’s agent-based ethics, in light of analysis of the grounding role of attitudes in the evaluation of two core cases. In light of these discussions, it is argued that there are advantages to preserving the grounding of the appropriateness of attitudes in facts about their objects (as opposed to Slote’s sentimentalism), while cutting such an agent-centered ethics away from a Kantian grounding.     

Spontaneous and learned turning behaviour in food- or water-restricted hooded rats

Some laboratory studies have suggested that whereas food restriction in animals leads to response alternation (behavioural flexibility), water restriction induces perseverative, stereotyped responding. Hooded rats, restricted to 1 hour per day access to either food or water, were tested on a radial-arm maze (using a procedure that eliminates algorithmic response strategies), for alternation in a 3-arm maze (both when the maze was familar and unfamilar, and with or without differential reward) and a 2-choice maze in which some animals were taught to alternate direction of turn, and others to perseverate. Both groups performed the radial-arm maze task competently and spontaneously alternated at a high rate. In the learned task, food-restricted rats were slower than water-restricted to reverse a consistent direction of turn; in the alternation condition, water-restricted rats developed a temporary, but strong, directional bias when making their first choice each day. Water-restricted subjects took water more readily than food-restricted took food when initially introduced to the apparatuses, but there was no consistent difference in motivation in the two conditions. The results provide little support for the notion that distinct cognitive-motivational states or behavioural strategies are induced by food- and water-restriction.     

The impact of politeness and relationship on perceived quality of advice about a problem

Advice is a common but potentially problematic way to respond to someone who is distressed. Politeness theory (Brown & Levinson, 1987) suggests advice threatens a hearer's face and predicts that the speaker‐hearer relationship and the use of politeness strategies can mitigate face threat and enhance the effectiveness of advice messages. Students (N=384) read 1 of 16 hypothetical situations that varied in speaker power and closeness of the speaker‐hearer relationship. Students then read 1 of 48 advice messages representing different politeness strategies and rated the message for regard shown for face and for effectiveness. However, neither speaker‐hearer relationship nor politeness strategies was consistently associated with perceived threat to face or perceived advice effectiveness. We suggest revisions to politeness theory and additional factors that may affect judgments of face sensitivity and advice effectiveness.     

Memory for targets in a multilevel simulated environment: Evidence for vertical asymmetry in spatial memory

In two experiments, adult participants explored a symmetrical three-tiered computer-simulated building that contained six distinctive objects, two on each floor. Following exploration, the objects were removed, and the participants were asked to make direction judgments from each floor, indicating the former positions of the objects on that floor and on higher and lower floors. Relative tilt error scores indicated a bias, in that targets that were higher than the test location were judged as consistently lower than their actual positions and targets that were lower than the test location were judged as consistently higher than their actual positions. Absolute tilt errors revealed an asymmetry, with more accurate and less variable tilt errors for judgments directed to lower floors than for judgments directed to higher floors. Experiment 3 ruled out an account of the findings that does not relate them to spatial memory. The results suggest that the superiority of downward over upward spatial judgments, previously reported in two-dimensional visual-spatial tasks, extends to navigational spatial memory.     

Scotopic sensitivity/Irlen syndrome and the use of coloured filters: a long-term placebo-controlled study of reading strategies using analysis of miscue

This study investigated the long-term effects of using coloured filters on the frequency and type of errors in oral reading. A double-masked, placebo-controlled crossover experimental design was used, with subjects being assessed over a period of 20 months. There were three experimental groups (Placebo tints, Blue tints, and Diagnosed tints) involving 113 subjects with reading difficulties, ranging in age from 9.2 yr. to 13.1 yr. The 35 controls (ranging in age from 9.4 yr. to 12.9 yr.) had reading difficulties but did not require coloured filters. There was a significant improvement for all groups in the accuracy of miscues over the period, although experimental groups over-all did not improve at a significantly different rate than the control group. The failure to find significantly greater improvement for the experimental groups over the control group for the total period, despite subjects' reports of improved print clarity, may be partly related to the lack of effective letter-sound analysis and synthesis skills and to the use of a word-identification strategy of guessing based on partial visual analysis.