Genetic polymorphisms of alcohol-metabolizing enzymes and their association with alcoholism risk,personality and anthropometric traits among Malaysian university students

Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes – ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. Therefore, we investigated the association of these three SNPs with alcohol-induced reactions (AIRs), alcoholism risk, personality and anthropometric traits among Malaysian university students. AIRs, Self-Rating of the Effects of Alcohol (SRE) and Ten-Item Personality were surveyed, anthropometric measurements and DNA samples were taken. Among 264 valid drinkers (111 males, 153 females; 229 ethnic Chinese, 35 ethnic Indians), the minor allele frequencies for ADH1B, ADH1C, ALDH2 among Chinese/Indians were .45/.07, .33/.40, .32/.41, respectively; distribution of ADH1B alleles significantly different between ethnicities. Current/former experiences of flushing, hives, heart palpitations after alcohol consumption; and sleepiness, headache reactions, early and overall SRE were significantly different between ethnicities and genders, respectively. Overall SRE score was associated with ADH1C and ALDH2 alleles. ‘Openness to Experiences’ was associated with ALDH2 genotypes and alleles; Glu/Glu or Glu carriers showed significantly higher means. ADH1B Arg/Arg and Arg carriers showed significantly higher total body and subcutaneous fats but association was abolished after controlling for ethnicity. In conclusion, gender and ethnicity, but not alcohol-metabolizing gene variants, play a role in influencing the manifestation of AIRs.     

Topological interlocking of protective tiles for the space shuttle

We propose a new concept of design of heat- and impact-resistant tile covering for space shuttles based upon topological interlocking of tiles. The key features of this type of tiling are as follows: firstly, the tiles are kept in place by virtue of the geometry of their contacting surfaces alone, so that no binding agent needs to be used; secondly, failure of an individual element does not compromise the structural integrity of the tile assembly and, moreover, a failed tile will be kept in place by its neighbours, thus maintaining its thermal protection function; thirdly, topological interlocking removes the need for connectors or other stress concentrators deleterious in extreme conditions of space flight and re-entry. Topological interlocking is scale and material independent, which permits combining tiles made from different materials in any proportion.