To determine the effects of both corticosterone (B) and chronic stressors on acute ACTH responses to restraint, young male rats were exposed to streptozotocin-induced diabetes, cold (5-7 degreesC) or intracerebroventricular (icv) neuropeptide Y (NPY) for 5 d and then exposed to restraint within 2 h after lights on. Two groups of rats were studied: intact and adrenalectomized replaced with B pellets that maintained plasma B in the normal mean 24-h range of intact rats. In addition to ACTH and B responses to restraint on d 5, body weight, food intake, fat depots, glucose and other hormones were measured to determine the role of stress-induced elevations in B on energy balance. ACTH responses to restraint were normal in intact rats subjected to diabetes or cold. By contrast, there was no ACTH or B response to restraint in NPY-infused intact rats. All 3 groups of chronically stimulated adrenalectomized rats with clamped B had facilitated ACTH responses to restraint compared to their treatment controls. Overall food intake increased in all groups of stressed rats; however, augmented intake occurred only during the light in intact rats and equally in the light and dark in B-clamped rats. White adipose depot weights were decreased by both diabetes and cold and increased by NPY in intact rats; the decreases with cold and increases with NPY were both blunted and changes in fat stores were not significant in adrenalectomized, B-clamped rats. We conclude that: 1. diabetes- and cold-induced facilitation of restraint-induced afferent input to hypothalamic control of the hypothalamo-pituitary-adrenal (HPA) axis is opposed in intact rats by the elevated feedback signal of B secretion; 2. NPY does not induce facilitation of afferent stress pathways; 3. chronic stimulation of the HPA axis induces acute hyperresponsiveness of hypothalamic neurons to restraint provided that the afferent input of this acute stimulus is not prevented by B feedback; 4. stimulus-induced elevations in B secretion result in day-time feeding; 5. insensitivity of both caloric efficiency and white fat stores to chronic stress in adrenalectomized, B-clamped rats results from loss of normally variable B levels. 相似文献
A lack of consensus persists as to whom exactly the dialogues of Wittgenstein's Philosophical Investigations are between: Wittgenstein and an interlocutor? Or perhaps a variety of interlocutors, none of whom can be identified with Wittgenstein himself? I argue here that this lack of consensus is possibly due to an ambiguity in the ordinary concept of “talking to oneself,” and that a new concept of “talking to oneself” appropriate to Wittgenstein's dialogues is needed to properly understand them. Wittgenstein is talking to himself—but he is doing so in the way we talk to other people. 相似文献
An increasing number of recent immigrants maintain intense connections with their countries and extended families. The complexity of relationships that arise from transnational connections calls into question dominant discourses about family bonds and requires that we adopt new theory and treatment considerations. The relational stresses and the almost untenable choices that economic immigrants face take the form of separations and reunions of parents and children, and difficult gender or generation transformations that need to be considered against this new transnational backdrop. This article proposes a model that encompasses foundational approaches with new approaches in family therapy by focusing on three crucial contexts for work with immigrants: the relational, the community, and the cultural-sociopolitical. Family therapists are also encouraged to create collaborative links with migration studies, a growing interdisciplinary field. 相似文献
This paper emphasizes the need for therapists to develop culturally attuned approaches to families. Family therapy strategies effective with families of Mexican descent are related to specific stages of the treatment process. Categories of problems presented by Mexican-American families are defined and corresponding therapist roles suggested. A specific class of interventions, labeledcultural strategies, makes use of culture in the service of therapy. Although the illustrations presented are of Mexican-American families, the concepts can be adapted to other ethnic families. 相似文献
The novel coronavirus has added new anxieties and forms of grieving to the myriad practical and emotional burdens already present in the lives of underserved and uninsured immigrant families and communities. In this article, we relate our experiences since the COVID-19 crisis to the lessons we have learned over time as mental health professionals working with families in no-cost, student-managed community comprehensive health clinics in academic-community partnerships. We compare and contrast the learnings of flexibility of time, space, procedures, or attendance we acquired in this clinical community setting during regular times, with the new challenges families and therapists face, and the adaptations needed to continue to work with our clients in culturally responsive and empowering ways during the COVID-19 pandemic. We describe families, students, professionals, promotoras (community links), and IT support staff joining together in solidarity as the creative problem solvers of new possibilities when families do not have access to Wi-Fi, smartphones, or computers, or suffer overcrowding and lack of privacy. We describe many anxieties related to economic insecurity or fear of facing death alone, but also how to visualize expanding possibilities in styles of parenting or types of emotional support among family members as elements of hope that may endure beyond these unprecedented tragic times of loss and uncertainty. 相似文献
Introduction: Prejudice and discrimination against transgender individuals (i.e., transphobia) is pervasive and has been shown to have pernicious effects on the physical (e.g., substance abuse and other self-harm behaviors) and psychological (e.g., depression and suicidal ideation) well-being of those targeted.
Aims: To date, a review of the psychometric properties of scales assessing transphobia has not been conducted; this gap compromises researchers' ability to make informed measurement decisions.
Methods: In the current study, 61 articles that contained 83 scales were identified, and their adherence to best practices in psychometric testing was evaluated.
Results: Most of the transphobia scales included in the current review did not provide sufficient information about item generation and refinement, scale dimensionality, scale score reliability, or validity. Each scale was entered into a table and was ranked on the basis of its total score. A score of 1 was issued for each psychometric feature that adhered to best practice guidelines, with total scores ranging from 0 to 5 (i.e., higher scores denote greater psychometric soundness).
Discussion: Properties of the reviewed scales are summarized and recommendations are made for future transphobia scale development and validation. The measures that emerged as possessing the highest scores and, subsequently, the greatest utility are identified. 相似文献