The Jerusalem TeleRehabilitation System, a new low-cost, haptic rehabilitation approach.

Survivors of brain injury or stroke can improve movement ability with intensive, supervised practice. Since the hours of supervised therapy with a physical or occupational therapist are limited, telerehabilitation will enable patients to greatly expand the hours that they practice therapeutic exercises. The Jerusalem TeleRehabilitation System (JTRS) consists of patient and therapist systems plus a central server and database connected via the internet. The system can work in two modes: (1) a cooperative mode in which the therapist and patient are online at the same time, and (2) a stand-alone mode in which the patient uses the system on his own. In both cases, the system will monitor the status and progress of the patient and various parameters of his movement abilities, and prepare reports for the patient and for the therapist. From the clinic, the therapist will be able to change the screen seen by the patient and change the level and types of tasks, as needed. Compared to existing systems, our system will have the following advantages: (1) inexpensive and easy to use; (2) remote monitoring and control of the patient's computer by the therapist in the clinic; (3) more detailed analysis of patient status and progress; (4) a "smart" system which self-adapts to the patient's capabilities in real time, increasing or decreasing the difficulty of the exercise as needed; and (5) a central, international database which, by gathering data on many patients over time, will provide the basis for "smart" therapy and will also facilitate coordinated multicenter research studies.     

Defining stuttering for research purposes

This is a response to a Letter to the Editor entitled “Stuttering prevalence, incidence and recovery rates depend on how we define it: Comment on Yairi & Ambrose’ article Epidemiology of Stuttering: 21st Century advances” by Paul Brocklehurst (2013). The criticism was directed specifically toward Yairi and Ambrose’ conclusions, based on review of recent studies, regarding the incidence and prevalence of stuttering. In this response, Brocklehurst's arguments and suggestions of criteria for incidence research are discussed and negated.     

An analysis of speech disfluencies in down''s syndrome and in normally intelligent subjects

Spontaneous speech samples were obtained from 19 institutionalized mongoloids and from 19 normally intelligent individuals. All subjects were evaluated by a panel of speech pathologists to be nonstutterers. Subjects' speech samples were analyzed to determine (a) frequency of occurance of seven disfluency categories per 100 words spoken, (b) the proportion of each category in the total number of disfluencies. Statistically significant differences indicated that the mongoloids were more disfluent both absolutely and relatively, on categories that have been regarded as most typical to speech of stutterers. Interpretations were made to reflect on factors which may enhance the high prevalence of stuttering among Down's Syndrome patients.     

What children infer from social categories

Children hold the belief that social categories have essences. We investigated what kinds of properties children feel licensed to infer about a person based on social category membership. Seventy-two 4-6-year-olds were introduced to novel social categories defined as having one internal - psychological or biological - and one external - behavioral or physical - property. For half of the participants, the internal property was described as causing the external one; for the others, no causal relationship between properties was mentioned. Children were asked to choose as a novel exemplar of a category one with only the internal or only the external property. Children inferred that exemplars had a psychological property irrespective of causal status, but they inferred the presence of a biological property only when described as causal. Children did not draw systematic inferences regarding either of the two external properties. These findings indicate that children treat psychological and causal properties as central - and perhaps essential - to human kinds.     

Genetic studies of stuttering in a founder population

Genome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions with nominal evidence for linkage were found on chromosomes 3 (P=0.013, 208.8 centiMorgans (cM)), 13 (P=0.012, 52.6 cM), and 15 (P=0.02, 100 cM). Regions with nominal evidence for association with stuttering that overlapped with a linkage signal are located on chromosomes 3 (P=0.0047, 195 cM), 9 (P=0.0067, 46.5 cM), and 13 (P=0.0055, 52.6 cM). We also conducted the first meta-analysis for stuttering using results from linkage studies in the Hutterites and The Illinois International Genetics of Stuttering Project and identified regions with nominal evidence for linkage on chromosomes 2 (P=0.013, 180-195 cM) and 5 (P=0.0051, 105-120 cM; P=0.015, 120-135 cM). None of the linkage signals detected in the Hutterite sample alone, or in the meta-analysis, meet genome-wide criteria for significance, although some of the stronger signals overlap linkage mapping signals previously reported for other speech and language disorders. EDUCATIONAL OBJECTIVES: After reading this article, the reader will be able to: (1) summarize information about the background of common disorders and methodology of genetic studies; (2) evaluate the role of genetics in stuttering; (3) discuss the value of using founder populations in genetic studies; (4) articulate the importance of combining several studies in a meta-analysis; (5) discuss the overlap of genetic signals identified in stuttering with other speech and language disorders.     

Memory of the traumatic event as a risk factor for the development of PTSD: lessons from the study of traumatic brain injury

Traumatic memories, and the mechanisms by which they operate, continue to occupy a central role in the scientific investigation of risk factors for the development of posttraumatic stress disorder (PTSD). However, empirically based studies are constrained by practical and ethical considerations and are limited to naturalistic models. Consequently, the paradigms most appropriate for the exploration of the relationship between traumatic memories and PTSD have been identified in conditions involving traumatic events where memories may be compromised. Indeed, traumatic brain injury, a condition that is commonly associated with memory impairment, has often been utilized as a naturally occurring model for the study of traumatic memory and its contribution to the development of PTSD. This article presents a critical review of these research efforts and discusses their theoretical and clinical implications.     

Strategic Polarization

In joint decision making, similarly minded people may take opposite positions. Consider the example of a marriage in which one spouse gives generously to charity while the other donates nothing. Such "polarization" may misrepresent what is, in actuality, a small discrepancy in preferences. It may be that the donating spouse would like to see 10% of their combined income go to charity each year, while the apparently frugal spouse would like to see 8% donated. A simple game-theoretic analysis suggests that the spouses will end up donating 10% and 0%, respectively. By generalizing this argument to a larger class of games, we provide strategic justification for polarization in many situations such as debates, shared living accommodations, and disciplining children. In some of these examples, an arbitrarily small disagreement in preferences leads to an arbitrarily large loss in utility for all participants. Such small disagreements may also destabilize what, from game-theoretic point of view, is a very stable equilibrium. Copyright 2001 Academic Press.     

Categorization generated by extended prototypes—An axiomatic approach

We suggest a model of categorization based on prototypes. A set of entities, identified with some finite dimensional Euclidian space, is partitioned into a finite number of categories. Such a categorization is said to be generated by extended prototypes if there is a set of distinguished entities, one for each category, such that the categorization is determined by proximity to these prototypical entities. The prototypes are called extended since they are described by points in a higher dimensional space than the entities. Sufficient conditions for a categorization to be generated by extended prototypes are provided. These conditions are also necessary if the prototypes are in general position.