Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity

We have demonstrated that non-patterned electrical stimulation of the lumbar cord can induce stepping-like activity in the lower limbs of complete spinal cord injured individuals. This result suggested the existence of a human lumbar locomotor pattern generator, which can convert a tonic input to a rhythmic motor output. We have studied the human lumbar cord in isolation from supraspinal input but under extrinsic tonic input delivered by spinal cord stimulation. Large-diameter afferents within the posterior roots are directly depolarized by the electrical stimulation. These afferents project to motoneurons as well as to lumbar interneurons involved in the motor control of lower limbs. Stimulation at 25-50 Hz can elicit rhythmic alternating flexion/extension movements of the lower limbs in supine individuals. Reducing the tonic input frequency to 5-15 Hz initiates lower limb extension. Epidural stimulation applied during manually assisted treadmill stepping in complete spinal cord injured persons immediately increases the central state of excitability of lumbar cord networks and enhances stepping-like functional motor outputs. Sustained, non-patterned tonic input via the posterior roots can activate human lumbar cord networks. Pattern generating configurations of these multifunctional circuitries can be set-up depending on the stimulation parameters and particularly on the input frequency.     

Definition,Foundation and Meaning of Illness: Locating Georg Groddeck in the History of Medicine

The paper reviews and discusses Groddeck's conception of illness. I first argue that Groddeck was a late Romanticist as much as he was a "wild" psychoanalyst. Then I use Groddeck's scattered formulations regarding definition, foundation, and meaning of illness in order to articulate them in the form of more explicit scientific statements. Finally, I suggest that Groddeck's theory of illness is fundamentally different from current medical conceptions, which, nevertheless, does not make our dialogue with him either less useful or indeed less necessary. It is through an investigation of Groddeck's therapeutic attitude and the spirit of his work that psychoanalysis and medicine can build foundations of bold, innovative, and healing future.     

A Serbian Version of Modified and Revised Experiences in Close Relationships Scale (SM–ECR–R)

We present details about the validation of the Serbian version of the Experiences in Close Relationships–Revised questionnaire modified to measure attachment in close relationships in general (SM–ECR–R). Its psychometric features were examined with 2 samples of students (N = 719 and N = 91) and 1 group of employed adults (N = 259). The results obtained in the student sample were equivalent to those obtained in validation studies worldwide, whereas in the more heterogeneous sample of employed adults, internal consistency of both avoidance and anxiety was lower and their intercorrelation was higher. Test–retest reliability was satisfactory, and relations with measures of attachment, empathy, and personality structure were meaningful. The results support the SM–ECR–R as a reliable and valid research instrument, but its internal structure and consistency might vary in different samples, depending on age, education, gender, and culture.     

Human Rights – Internationally Established Standards as Challenged by Constitutional Policies

Studies in East European Thought -