Stress-induced Fos-like Immunoreactivity in the Pons and the Medulla Oblongata of Rats

Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response.     

Parenting of children with attention-defecit/hyperactivity disorder (ADHD): the role of parental ADHD symptomatology

OBJECTIVE: The present study examined the relation between parental ADHD symptomatology and parent-child behavior among 46 mothers and 26 fathers of ADHD children. RESULTS: Fathers' self-reports of inattention and impulsivity were strongly associated with self-reports of lax parenting both before and after parent training, and with self-reports of overreactivity after parent training. Fathers' impulsivity was also associated with more arguing during audiotaped observations of parent-child interactions prior to parent training. Mothers' self-reports of inattention were modestly associated with self-reports of laxness before and after parent training. Prior to parent training, there were non-linear relations between mothers' inattention and observations of mother-child behavior, with mothers who reported moderate levels of inattention engaging in the most negative parent-child interactions. After parent training, these relations were linear, with the mothers who reported the most inattention engaging in the most negative parent-child interactions. These results were weakened but were generally still significant when parental depression and alcohol use were controlled.     

Interrater reliability of teacher rating scales for children with attention-deficit hyperactivity disorder

Interrater reliability of eight teacher rating scales designed to assess characteristics of attention-deficit hyperactivity disorder was investigated. Coteachers of 46 students completed the rating scales. The students, ages 8–17, were designated as having a Serious Emotional Disturbance. The resulting interrater reliability correlation coefficients ranged from .62 to .87. The percentage of variance shared between raters ranged from a low of 38.4% (the ACTeRS Oppositional factor and the CBCL-TRF Attention Problems factor) to 75.7% (ADHD Rating Scale). The percent of shared variance was higher for younger children. Kappa scores evaluating rater agreement were highest at the two standard deviations above the mean cutoff. The reliability coefficients were consistent with those reported in prior research.     

Field-dependence, extraversion and perception of the vertical: empirical and theoretical perspectives of the rod-and-frame test.

Using conventional scoring procedures for the Rod-and-frame Test (RFT), extraversion was shown to interact with field-dependence (defined by scores on the Hidden-shapes Test), with the field dependent extraverts being most inaccurate performers on the rod and frame. Of greater importance, serious questions were raised about theoretical and empirical aspects of the relationship between paper-and-pencil measures of field-dependence and performance on the rod and frame, and it was concluded that "what has...been demonstrated over the past ten years is the reliability of a relationship of questionable validity."     

Measuring the Happiness of Large-Scale Written Expression: Songs,Blogs, and Presidents

The importance of quantifying the nature and intensity of emotional states at the level of populations is evident: we would like to know how, when, and why individuals feel as they do if we wish, for example, to better construct public policy, build more successful organizations, and, from a scientific perspective, more fully understand economic and social phenomena. Here, by incorporating direct human assessment of words, we quantify happiness levels on a continuous scale for a diverse set of large-scale texts: song titles and lyrics, weblogs, and State of the Union addresses. Our method is transparent, improvable, capable of rapidly processing Web-scale texts, and moves beyond approaches based on coarse categorization. Among a number of observations, we find that the happiness of song lyrics trends downward from the 1960s to the mid 1990s while remaining stable within genres, and that the happiness of blogs has steadily increased from 2005 to 2009, exhibiting a striking rise and fall with blogger age and distance from the Earth’s equator.     

The establishment of stimulus control by instructions and by differential reinforcement

A repeated acquisition design was used to study the effects of instructions and differential reinforcement on the performance of complex chains by undergraduates. The chains required responding on a series of keys that corresponded to characters that appeared on a monitor. Each day, subjects performed a new chain in a learning session and later relearned the same chain in a test session. Experiment 1 replicated previous research by showing that instructional stimuli paired with the correct responses in the learning sessions, combined with differential reinforcement in both learning and test sessions, resulted in stimulus control by the characters in each link. Experiment 2 separated the effects of instructional stimuli and differential reinforcement, and showed that stimulus control by the characters could be established solely by differential reinforcement during the test sessions. Experiment 3 showed that when a rule specified the relation between learning and test sessions, some subjects performed accurately in the test sessions without exposure to any differential consequences. This rule apparently altered the stimulus control properties of the characters much as did differential reinforcement during testing. However, compared to differential reinforcement, the rule established stimulus control more quickly.     

Validity of the parenting scale for parents of children with attention-deficit/hyperactivity disorder

The present study examined the validity of the parenting scale for parents of elementary school-aged children with attention-deficit/hyperactivity disorder (ADHD). Parents from 109 families with children who had been diagnosed with ADHD (106 mothers and 93 fathers) and from 70 families with non-problem children (69 mothers and 59 fathers) completed the parenting scale and reported on their children's behavior problems. Factor analyses revealed two interpretable factors for both mothers and fathers, corresponding to the overreactivity and laxness factors identified in previous studies of the parenting scale. Overreactivity and laxness scores were significantly higher for mothers and fathers of ADHD children than of non-ADHD children; this effect appeared to be accounted for by comorbid aggression and conduct problems among ADHD children. Results support the validity of the parenting scale for use with parents of ADHD children.     

Identification of coping ideation and strategies preventing suicidality in a college-age sample.

This study attempts to identify coping mechanisms relevant to the prevention of progressive lethality in suicidal behavior among youth. College students (N = 296) aged 18 to 24, self-identified as having no past suicidal ideation, mild ideation, severe ideation, or having attempted suicide, completed the Reasons for Living Inventory (Linehan, Goodstein, Nielson, & Chiles, 1983), a similarly derived instrument for age-specific coping cognitions, and a scale of coping strategies for diminishing suicidality. Discriminant functions analyses of the mean factor scores for each scale were used to assess the pertinence of various coping mechanisms among the 4 groups. Patterns of similarities and differences in mechanisms were identified.     

Adolescents', parents', and teachers' distress over adolescents' behavior

This study evaluated adolescents', parents', and teachers' self-reported distress and wishes to change adolescents' emotional/behavioral problems in a sample of clinically referred adolescents. Parents reported being bothered more than adolescents or teachers by adolescents' internalizing behavior. Both parents and teachers rated adolescents' externalizing behavior as more bothersome than did adolescents. Adolescents were significantly less likely to want to change their behavior than were parents or teachers. In addition, adolescents were significantly more likely to want to change their internalizing problems than their externalizing problems. For all three informants, being bothered by adolescents' behaviors was strongly associated with a desire to change the behaviors. Clinical implications of these findings are discussed.The authors wish to thank John Iriye and Alisa Waldman for their invaluable help as research assistants.