Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

Theophrastus Bombastus Von Hohenheim: Theological Reformer,Philosopher and Physician

Journal of Religion and Health - Theophrastus Bombastus Von Hohenheim (1493–1541), known as Paracelsus, was a German-Swiss Renaissance man. His interests included alchemy and medicine. During...     

Modeling variability of force during isometric contractions of the quadriceps femoris

The authors modeled variability of force during continuous isometric contractions of the quadriceps femoris. Twenty adults (aged 25 +/- 6 years old) performed isometric leg extensions. Target forces were 11 percentages of maximum voluntary contraction (%MVC), ranging from 2 to 95%, and 5 absolute levels, from 25 to 225 N. The authors used standard deviation of absolute force, coefficient of variation, and signal-to-noise ratio as measures of variability. The results suggested a nonlinear relationship between variability and level of force, which could best be expressed as %MVC and not as absolute force. Variability for continuous isometric contractions was described best by a sigmoidal logistic function. The sigmoidal pattern of variability as a function of %MVC is consistent with physiological mechanisms.     

Force Control Is Greater in the Upper Compared With the Lower Extremity

The authors investigated whether force control is similar between the upper and lower limbs and between contractions that involve 1 or 2 joints. Six volunteers (27.5 ± 11.2 years of age) attempted to produce consistent discrete rapid force responses of 30, 60, and 90 N by using 6 different body postures, 3 with the upper and 3 with the lower limb. One of the postures for each limb involved 2 joints. The standard deviation of peak force and impulse (aggregate of the force-time curve) was significantly greater (?25%) for the lower limb than for the upper limb (p < .01). Contractions that involved 1 or 2 joints within a limb had similar variability. Therefore, the upper limb might have better control of force than the lower limb because of its extensive use in fine motor tasks in daily activities.     

Links between relational aggression,parenting and personality among adolescents

The aim of this cross-sectional study was to examine the mediating role of behavioral inhibition system, referring to the inhibition of behavior, and behavioral activation system (BAS), related to impulsivity, in the association between perceived parenting behaviors and relational aggression. It simultaneously investigated the moderating effects of callous-unemotional (CU) traits in this association in a sample of 261 (127 girls) Greek junior high school students who completed a self-report questionnaire. Results of the mediation analyses revealed that BAS was a partial mediator in the relationship between low parental psychological autonomy and relational aggression, as well as between low parental behavioral control and relational aggression. The effect of low parental psychological autonomy on relationally aggressive behavior was also significantly stronger when CU traits were present (moderator). The results emphasize that both individual and interpersonal factors should be taken into consideration when studying relational aggression.     

The probability of causal conditionals

Conditionals in natural language are central to reasoning and decision making. A theoretical proposal called the Ramsey test implies the conditional probability hypothesis: that the subjective probability of a natural language conditional, P(if p then q), is the conditional subjective probability, P(q/p). We report three experiments on causal indicative conditionals and related counterfactuals that support this hypothesis. We measured the probabilities people assigned to truth table cases, P(pq), P(p notq), P( notpq) and P( notp notq). From these ratings, we computed three independent predictors, P(p), P(q/p) and P(q/ notp), that we then entered into a regression equation with judged P(if p then q) as the dependent variable. In line with the conditional probability hypothesis, P(q/p) was by far the strongest predictor in our experiments. This result is inconsistent with the claim that causal conditionals are the material conditionals of elementary logic. Instead, it supports the Ramsey test hypothesis, implying that common processes underlie the use of conditionals in reasoning and judgments of conditional probability in decision making.     

Iffy beliefs: Conditional thinking and belief change

The ability to entertain possibilities and draw inferences about them is essential to human intelligence. We examine the hypothesis that conditional if-then statements trigger a mental simulation process in which people suppose the antecedent (if statement) to be true and evaluate the consequent (then statement) in that context. On the assumption that supposing an event to be true increases belief that the event has occurred or will occur, this hypothesis is consistent with the claim that evaluating a conditional will heighten belief in its antecedent more than in its consequent. Two experiments, employing conditionals of the form If animal A has property X, then animal B will have property X, in which X was a property that people could not readily relate to the animals, supported this claim. The effect was stronger following the evaluation of conditionals with dissimilar animal categories.     

View dependence in scene recognition after active learning

Human spatial encoding of three-dimensional navigable space was studied, using a virtual environment simulation. This allowed subjects to become familiar with a realistic scene by making simulated rotational and translational movements during training. Subsequent tests determined whether subjects could generalize their recognition ability by identifying novel-perspective views and topographic floor plans of the scene. Results from picture recognition tests showed that familiar direction views were most easily recognized, although significant generalization to novel views was observed. Topographic floor plans were also easily identified. In further experiments, novel-view performance diminished when active training was replaced by passive viewing of static images of the scene. However, the ability to make self-initiated movements, as opposed to watching dynamic movie sequences, had no effect on performance. These results suggest that representation of navigable space is view dependent and highlight the importance of spatial-temporal continuity during learning.     

On the basis of belief in causal and diagnostic conditionals

According to the suppositional theory of conditionals, people assess their belief in a conditional statement of the form “if p then q” by conducting a mental simulation on the supposition of p in which they assess their degree of belief in q. This leads to them to the judge the probability of a conditional statement to be equal to the conditional probability, P(q|p). Evidence for this conditional probability hypothesis has been adduced in earlier studies for abstract, causal, and counterfactual conditionals. For the realistic conditionals, it is natural to assume that people perform such mental simulations by building causal mental models from prior causes to later effects. However, in the present study we show that the conditional probability hypothesis extends to diagnostic conditionals, which relate effects to causes. This new finding presents a major challenge for theoretical accounts of the mental processing of conditional statements.     

Cyber-bullying: An investigation of the psychological profile of university student participants

The present study investigated the psychological profile of 430 Greek university students who reported cyber-bullying/victimization experiences. Participants completed a self-report questionnaire, measuring cyber-bullying, cyber-victimization, Internet frequency and use, personality characteristics, and psychological symptoms. Results indicated that 58.4% of the sample had participated in a cyber-bullying incident assuming any role. Cyber bully/victims, the most common participant role, endorsed more psychological symptoms, more psychopathic traits, and were high sensation seekers, compared to the rest of the groups, whereas cyber-victims scored higher on empathy. Cyber-bullying was predicted by callous/unemotional and impulsive/irresponsible traits, depression, Internet use, as well as lack of social skills. The latter four variables also predicted cyber-victimization along with gender. Findings are discussed in terms of prevention and intervention strategies.