Microinjections of leupeptin in the frontal cortex or dorsal hippocampus block spatial learning in the rat

Adult male Long-Evans hooded rats were given bilateral microinjections of 18 mM leupeptin or saline through cannulae implanted with tips aimed at the frontal cortex or CA1 or CA3 hippocampal cell fields. Five minutes following injections animals were allowed to complete an eight-arm radial maze. The acquisition criterion required that the animal make 7 correct choices of the first 8, and 8 correct choices of the first 10, for five consecutive sessions. Leupeptin slowed acquisition of the eight-arm radial maze task when injected into the CA1 and CA3 hippocampal fields or the frontal cortex, but did not influence spontaneous activity. These results suggest that earlier reports of the amnestic effect of leupeptin when administered into the lateral cerebral ventricle may have been due to effects within the cortex and hippocampus. The present experiment represents the first attempt to identify behaviorally those brain areas in which leupeptin acts to alter learning.     

FUNCTIONAL COMMUNICATION TRAINING WITH AND WITHOUT EXTINCTION AND PUNISHMENT

Functional communication training has been reported to be a promising treatment for severe behavior problems. In this study, functional communication training alone and combined with extinction and/or punishment was evaluated for 4 clients with severe retardation, behavior problems, and communication deficits. The participants were inpatients on a hospital unit for treatment of severe behavior disorders. They received individualized interventions based on functional assessment that included reinforcement of a communication response with the same function as their destructive behavior. Results showed that for some patients, functional communication training was not sufficient to produce clinically significant reductions in destructive behavior, and the combination of training plus punishment produced the largest and most consistent reductions.     

Simple disturbance of the dam in the neonatal period can alter haloperidol-induced catalepsy in the adult offspring

Three experiments were performed to determine whether apparently minimal disturbances of dams and litters would influence haloperidol-induced akinesia. In Experiment I, Long-Evans hooded rats (a) were left unmanipulated, (b) received nestcage relocation and observation, (c) received nestcage relocation/observation and maternal separation, or (d) received nestcage relocation/observation and pup handling. The male adult offspring received open-field testing and later received forepaw-on-dowel catalepsy testing following saline, morphine (20 mg/kg), or haloperidol (2 mg/kg). In Experiment II, hooded rats received (a) no manipulation, (b) nestcage relocation, (c) maternal separation, or (d) pup handling. At weaning, dams were tested in the open-field. Activity wheel locomotion of the offspring was assessed following saline or haloperidol for 3 days/week for 3 weeks; then, 5 and 7 days later, rats received haloperidol (0.5 mg/kg) and catalepsy testing. In both experiments, manipulations involving the dam reduced the offsprings' haloperidol-induced catalepsy, but, in Experiment II, a history of haloperidol administration distinguished between the effects of nestcage relocation and maternal separation. In Experiment III, Swiss albino mice received (a) no treatment, (b) nestcage relocation and maternal separation, (c) relocation/separation and mild cold stress of pups, (d) relocation/separation and pup handling, or (e) relocation/separation and severe cold stress of pups. Adult male mice received saline or haloperidol (2.5 mg/kg) and inclined grid catalepsy testing. Mice receiving relocation/separation and mice receiving relocation/separation and severe cold stress showed enhanced catalepsy versus control mice. Thus, it was concluded that seemingly innocuous events in infancy can influence the intensity of extrapyramidal side effects of neuroleptics in adulthood.     

You can't always get what you want: educational attainment, agency, and choice

Using educational attainment to indicate socioeconomic status, the authors examined models of agency and effects of choice among European American adults of different educational backgrounds in 3 studies. Whereas college-educated (BA) participants and their preferred cultural products (i.e., rock music lyrics) emphasized expressing uniqueness, controlling environments, and influencing others, less educated (HS) participants and their preferred cultural products (i.e., country music lyrics) emphasized maintaining integrity, adjusting selves, and resisting influence. Reflecting these models of agency, HS and BA participants differently responded to choice in dissonance and reactance paradigms: BA participants liked chosen objects more than unchosen objects, but choice did not affect HS participants' preferences. Results suggest that HS and BA models of agency qualitatively differ, despite overlap between HS and BA worlds.     

Implicit self-attitudes predict spontaneous affect in daily life

In 2 studies, the authors examined the degree to which implicit self-attitudes predicted people's spontaneous affective experiences in daily life. Across both studies, implicit attitudes toward the self (as measured by Implicit Association Tests) strongly predicted negative feeling states (as measured by computerized experience-sampling procedures), suggesting that implicit self-attitudes may be linked to changes in undifferentiated negative affect. Explicit attitudes toward the self generally did not account for these relations. Findings extend understanding of the factors that contribute to experienced affect and are the first to empirically link implicit self-attitudes with phenomenological affective experience in real-life settings over time.     

NEO-PI-R neuroticism scores in substance-dependent outpatients: internal consistency and self-partner agreement

We evaluated internal consistency reliabilities and self-partner agreement on Revised NEO Personality Inventory (Costa & McCrae, 1992) Neuroticism (N) domain and facet scores (anxiety, angry hostility, depression, self-consciousness, impulsiveness, vulnerability) in a sample of 48 substance-dependent outpatients. Low internal consistency was seen for self-rated impulsiveness (alpha =.36). Agreement between self and partner reports was low for impulsiveness (.22) and vulnerability (.24) and was modest for the remaining facets of N (.31 to.34) and the N domain score (.31).     

Alcohol Consumption and the Theory of Planned Behavior: An Examination of the Cognitive Mediation of Past Behaviorid

This study examined the predictive power of the theory of planned behavior (TPB) in explaining alcohol consumption in 3 prospective samples of students ( Ns = 178. 176. and 159). Generally, the TPB performed well. with attitudes, subjective norms and perceived behavioral control (PBC) explaining between 28% and 46% of the variability in intentions. Intentions and PBC explained between 12% and 50% of the variability in behavior. Measures of self-identity as a "drinker" and past behavior contributed to predictions of intentions over and above the contribution of attitudes. subjective norms. and PBC. Measures of past behavior but not self-identity consistently contributed to predictions of behavior over and above the contributions from intentions and PBC. The direct relationship between past behavior and intention and between past behavior and behavior (independent of the TPB variables or self-identity) could not be attributed to common method variance.     

When Good Intentions Are Not Enough: Modeling Postdecisional Cognitive Correlates of Condom Use1

Measures of intention usually leave substantial proportions of the variance in behavior unexplained. It has been suggested that improved behavioral prediction could be achieved by identifying postdecisional cognitive processes capable of distinguishing between intenders who do act and those do not act. Condom-related self-report measures of postdecisional cognitive processes were developed and tested in a cross-sectional questionnaire study involving 447 heterosexual students. A discriminant function composed of postdecisional measures was found to significantly distinguish between intenders who reported use and non-use and to correctly classify 80% of intenders. The results indicate that measures of the relative importance of competing intentions, prior planning of specific preparatory actions, and action-specific self-efficacy may enhance the prediction of condom use among intenders.     

Using self-generated validity to promote exercise behaviour

Self-generated validity (SGV) refers to the fact that measurement of cognitions can lead to behaviour change. The present research tested to two predictions in relation to SGV: SGV is stronger when supplementing measures of intentions and other components of the Theory of Planned Behaviour (TPB) with measures of anticipated regret; SGV is only stronger when measuring anticipated regret before measuring intentions and other components of the TPB. A total of 576 18-22-year-old students were randomly allocated to complete one of three questionnaires in relation to exercise: (1) TPB questionnaire in relation to exercising in a sports centre (TPB only); (2) TPB questionnaire including anticipated regret questions that appear after intention items and are mixed in with other items (TPB + regret mixed); (3) TPB questionnaire with anticipated regret questions first (TPB + regret first). Past use of the sports centre was also measured by self-report in all conditions. Use of the sports centre 4 and 5 weeks later was measured based on objective records. Hierarchical regression analyses indicated no effect of measuring anticipated regret compared to only measuring TPB variables, but a significant effect of measuring anticipated regret first compared to the other two conditions on sports centre use. This effect persisted after controlling for TPB variables and past behaviour (PB). The effect was moderated by intention strength but not PB. Implications for understanding SGV and behaviour change are discussed.