Cocaine-but not methamphetamine-associated memory requires de novo protein synthesis

Context-induced drug craving and continuous drug use manifest the critical roles of specific memory episodes associated with the drug use experiences. Drug-induced conditioned place preference (CPP) in C57BL/6J mouse model, in this regard, is an appropriate behavioral paradigm to study such drug use-associated memories. Requirement of protein synthesis in various forms of long-term memory formation and storage has been phylogenetically demonstrated. This study was undertaken to study the requirement of protein synthesis in the learning and memory aspect of the conditioned place preference induced by cocaine and methamphetamine, two abused drugs of choice in local area. Since pCREB has been documented as a candidate substrate for mediating the drug-induced neuroadaptation, the pCREB level in hippocampus, nucleus accumbens, and prefrontal cortex was examined for its potential participation in the formation of CPP caused by these psychostimulants. We found that cocaine (2.5 and 5.0 mg/kg/dose)-induced CPP was abolished by the pretreatment of anisomycin (50 mg/kg/dose), a protein synthesis inhibitor, whereas methamphetamine (0.5 or 1.0 mg/kg/dose)-induced CPP was not affected by the anisomycin pretreatment. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. Moreover, anisomycin treatment 2h after each drug-place pairing disrupted the cocaine-induced CPP, whereas the same treatment did not affect methamphetamine-induced CPP. An increase of accumbal pCREB level was found to associate with the learning phase of cocaine, but not with the learning phase of methamphetamine. We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins.     

Examining the Growth Trajectories of Physical Education Students’ Motivation,Enjoyment, and Physical Activity: A Person-Oriented Approach

The study examined the growth trajectories in 757 (M age = 12.71) Finnish middle school students’ intrinsic and extrinsic motivation along with their enjoyment and physical activity. In addition, the study aimed to examine the role of intrinsic and extrinsic physical education motivation in the development in adolescents’ enjoyment and physical activity by identifying adolescents’ subgroups. Adolescents’ enjoyment and physical activity declined, intrinsic motivation was stable, and extrinsic motivation increased across middle school. Adolescents with highest levels of intrinsic motivation and moderate to high levels of extrinsic regulation had the highest levels of enjoyment and physical activity.     

Emotional Intelligence of Foreign and Local University Students in Singapore: Implications for Managers

Does intelligence alone explain our achievement at work or in life? Contrary to our belief that academic achievement matters very much in the success we have in working life, Chen et al. (1998) has shown that close to 90% of success in leadership positions is attributable to Emotional Intelligence (EI). Considering that EI can be a potential determinant of our achievement in working life, this study aims to determine if there is any significant difference in the EI of local and foreign undergraduates studying in universities in Singapore. The “Emotional IQ Test” was administered to 100 undergraduates from various fields of studies from the National University of Singapore and Nanyang Technological University, of which 31 had foreign education background. This study showed that foreign undergraduates have a higher EI score than those with local education background. In addition, by examining the relationships between variables such as age, gender, year of study and EI, it was found that males have higher EI scores than that of females. The implication for managers is that staff should be evaluated on their own merits such as their EI rather than on academic results.     

Metalinguistic Filters Within the Bilingual Language Faculty: A Study of Young English-Chinese Bilinguals

This study reports two metalinguistic parameters that constitute the schematic control of lateral inhibitory links between translation equivalents within the bilingual lexico-semantic system of Green’s (Bilingualism: Language and Cognition 1:67–81, 1998a, Bilingualism: Language and Cognition 1:100–104, 1998b, The bilingualism reader, Routledge, London, 2007) inhibitory control (IC) model. Building on Green’s postulation that the bilingual lexico-semantic system is controlled by a hierarchy of schemas under a supervisory attentional system, the bilingual unconsciously filters activated lemmas during fluent spontaneous codeswitching, such that lemmas that are semantico-syntactically versatile or morphosyntactically transparent are likely to reach a threshold of activation first while other lemmas are inhibited. To investigate the issue, we collected code-paired naturalistic and elicited data with a focus on code-switched determiner phrases from 140 Mandarin-English simultaneous bilinguals who were post-secondary students in Singapore. We found that the semantico-syntactic and morpho-syntactic dissimilarities between Mandarin and English activated both filters. As most Mandarin determiners are economical vis-à-vis their English counterparts, their lemmas were selected frequently while English lemmas were largely inhibited. It was also found that our participants preferred English nouns in filling the lexical category for their interpretable feature of number, a feature that is normally absent in Mandarin nouns.     

The role of the anterior left hemisphere in real-time sentence comprehension: evidence from split intransitivity

We investigate Broca's sentence comprehension as an impairment on normal syntactic composition: the slow-syntax hypothesis (SSH). Experiment 1 examines comprehension of object-relative clauses (Wh-movement). Experiment 2 examines comprehension of sentences with unaccusative verbs (NP-movement), which like passives, base-generate their theme-argument in object position. Guided by the SSH, both experiments test the prediction that syntax-dependent effects such as "gap-filling" are observable but in a delayed fashion. Results show that whereas no priming was obtained at the point of the trace, antecedent reactivation emerged 650 and 800 ms after the verb (for Wh- and NP-movement respectively). This shows, contrary to dependency-based generalizations, that Broca's patients are able to successfully implement dependencies, albeit in a protracted manner. Given the localization value provided by Broca's aphasia, this supports the notion that the temporal implementation of syntactic structure formation (i.e., the requirement that it be fast and automatic) depends on the integrity of the anterior left hemisphere.     

Impact of telepresence levels on internet advertising effects.

This study examined the dimensions of interactivity and vividness to propose three telepresence levels: content presence, social presence, and personal presence. Then, an experiment investigated the impact of different telepresence levels on Internet advertising. The effects of interactions between vividness of visual imagery (VVI) and product types in relation to telepresence levels and advertising effects were also analyzed. The study employed a factorial design: 4 (levels of telepresence) x 2 (product types) x 2 (VVI). Levels of telepresence and product types were both manipulated between subjects. VVI was measured within subjects. Experimental findings showed that high levels of telepresence of an Internet advertisement increased subject recall and recognition. The low VVI respondent group would have greater recognition than traditional advertisements when respondents were exposed above the level 2 (social presence) advertisement and the effect of recognition increased from level 1 (content presence) to level 3 (personal presence). Recognition increased from level 1 (content presence) to level 2 (social presence) for both search and experience product groups; however, only recognition of the experience product group increased in level 3 (personal presence).     

The impact of dialectical behaviour therapy training on therapists in Singapore: A mixed-methods study

Background

While dialectical behaviour therapy (DBT) has much empirical support for treating borderline personality disorder (BPD) and other conditions, little research has examined the dissemination of DBT in Southeast Asia.

Aims

This study evaluated training outcomes following a 5-day intensive DBT training programme in a group of psychologists in Singapore, who were in the process of implementing DBT as part of the training's objectives.

Methodology

A mixed-methods design was employed. Fourteen psychologists from a public psychiatric hospital in Singapore were recruited. Seven self-selected into DBT training, and the remaining were matched controls who were not attending the training programme. The latter served as a nonrandomised control group. Prior to and 3 months after training, all participants completed measures of stigma towards BPD patients, burnout and therapeutic alliance. DBT training participants additionally attended a focus group discussion assessing their experiences and challenges implementing DBT in Singapore's context.

Findings

Quantitative analyses using mixed ANOVA showed that, compared with controls, DBT-trained participants demonstrated significantly greater increases in acceptance towards BPD patients. No between-group differences were found on changes in burnout or therapy alliance with patients. Analyses of qualitative data using thematic analysis revealed that DBT training impacted the way participants conceptualised and delivered therapy for BPD patients, and highlighted several challenges in implementing DBT in the local hospital context.

Conclusion

The findings demonstrate the potential of DBT training in improving clinicians' attitudes towards BPD patients and support a need for policymakers to prepare organisations for DBT implementation to ensure programme sustainability.     

Home Environment and Classroom Climate: An Investigation of their Relation to Students’ Academic Self-Concept in a Streamed Setting

Many studies concur that students’ perceptions of their home and school environments, such as relationships with parents and teachers, are related to their academic self-concept (for example, Chang et al., Int J of Behav Dev 27(2):182–189, 2003; Ireson and Hallam, Br J Educ Psychol 75:297–311, 2005; Jang, J Kor Home Econ, 39:101–114, 2001; Lau and Leung, Br J Educ Psychol, 62:193–202, 1992; Lau and Pun, Social Behav Pers, 27(6):639–650, 1999; Masche and Barber, “Connectedness and separation in parent-adolescent relationships: Indicators of a successful identity development.” Paper presented at the SRCD Biennial Meeting, Minneapolis, MN, April 19–22, 2001; Sanders, “School–family–community partnerships and the academic achievement of African American, urban adolescents.” Report No. 7. EDRS. ED 402404, 1996). Nonetheless, little is known about whether the strength of the relationships is comparable for students of different ability streams, or if the predictors of variance of their academic self-concept are similar. To fill the empirical gap, a 3-year longitudinal study was conducted with Secondary One students (approximate age 13) from three government schools in Singapore. Pearson product–moment correlation and Fisher’s z _r transformation showed that there were significant differences in the strength of the relationships between higher- and lower-ability stream students’ academic self-concept and their perceived home environment and classroom climate. In addition, stepwise multiple linear regressions established that lower-ability stream students’ perceived teachers’ expectations had more consistent and substantial impact on their confidence level than that of their higher-ability stream counterparts. In comparison, higher-ability stream students’ perceived parental academic support had more consistent impact on their academic self-concept than that of their lower-ability stream peers.