Acoustic markers associated with impairment in language processing in Alzheimer's Disease

This study broaches in a novel way the analysis of cognitive impairment characteristic of the early stages of Alzheimer's Disease (AD). Specifically, we attempt to determine the acoustic speech parameters that are sensitive to the onset of the disease, and their association with the language deficit characteristic of AD. Speech analysis was carried out on 21 elderly patients with AD using Praat software, which analyzes the acoustic components of speech. The data obtained were subjected to stepwise regression, using the overall scores obtained in the test as the criterion variable, and the scores on the frequency, amplitude and periodicity variables as predictors of performance. We found that the percentage of voiceless segments explains a significant portion of the variance in the overall scores obtained in the neuropsychological test. This component seems to be related mainly to the patient's ability in phonological fluency. This finding could permit the creation of a diagnostic test for AD through analysis of the acoustic speech parameters at very low cost in terms of both time and resources.     

A relationship with Señor de Carácuaro

The present paper explores the issue of personal relationships in the context of pilgrimage. Most literature about pilgrimage in Latin America focuses on the journey, or on the alleged ‘sacred power’ located in the shrine and sought by the pilgrims. I argue that, from the perspective of the participants’ experience, pilgrimage could be understood in terms of personal relationships with particular holy beings, who are perceived as agents. Through the particular case of Marta, a young Purhépecha woman from Lake Pátzcuaro (Mexico), I will examine the modes in which people from this area relate, interact and communicate with saintly beings in the context of pilgrimage; the connection of vows with quotidian experience; and the implications of relationships with saints for people in their everyday lives.     

Emotion and recognition memory: the discrimination of negative information as an adaptive process

We studied the effect of emotion generated by IAPS (International Affective Picture System) pictures on incidental recognition of these pictures for short retention periods (15 min). Memorization distraction tasks and reaction time tasks were used together with short exposure times (2 seconds per picture) in order to prevent a high recognition rate that would impede testing for the effect of emotion on discrimination parameters (A′) and response bias (B′′D) (ceiling effect). We used 80 pictures representing the medium and high levels of two-dimensional emotional space. The results showed greater discrimination and a more conservative response style to unpleasant and medium arousal level pictures. These pictures produced higher confidence and lower response times in the recognition phase. The results can be explained by the negative content of the pictures and activation level effects on attentional processing and memory, and can be interpreted as a phenomenon that is evolutionarily adaptive.     

Intention superiority effect on implicit memory of shopping lists: Activation and inhibition processes

Intentional memory is defined as the ability to remember to perform intentions in the future. Forming an intention such as “shopping” activates access to memories related to the products on the shopping list. As Intention Superiority Effect (ISE) studies show, these memories are more accessible in semantic and episodic memory, more activated over time and protected from competing representations. The inhibition of competing representations in intentional memory has been little examined so far. In this study we attempt to analyze changes in activation in the recall of products on a shopping list and competitors through implicit memory tasks. Sixty-five participants learned two shopping lists on a computer. Later, they were told to virtually buy one of them (prospective list) and not the other (neutral list). Prior to intentional task execution, they performed an implicit retrieval task in which we manipulated the appearance or not of cues from the intentional list and analyzed the influence of the items from the intentional list on items related to intentional and neutral lists. The main result of this study is that intention retrieval by intentional cues strengthens the activation of products related to the intentional list and/or inhibits competing products related to the neutral list. The inhibition is episodic rather than semantic in nature. The ISE requires the recall of the intention during the retention period through intentional cues for maintaining the intention. This seems to defend automatic recovery theories and not the intention persistence hypothesis. Also, the results are better explained by the directed forgetting paradigm rather than by the retrieval-induced forgetting paradigm.     

Satisfaction,involvement, and unconditional care: The perceptions of children and adolescents receiving wraparound services

Client satisfaction has emerged as an important variable in evaluating outcomes for mental health treatment, yet studies have seldom queried children and adolescents about their perceptions of the services they receive. The present study surveyed 20 youths receiving community-based, wraparound services about their satisfaction, sense of involvement, and feelings of unconditional care. Unconditional care, in this case, referred to the youth's sense that his or her caretakers would remain stable regardless of what happened. Each of these variables was in turn related to behavioral adjustment. It was found that both youths' sense of involvement and their perceptions that their care was unconditional were strongly associated with satisfaction with services. However, neither satisfaction nor involvement were correlated with the severity of subjects' acting-out behaviors. Subjects' perception that care was unconditional was strongly, negatively correlated with the severity of acting-out behaviors. Thus, while the relationship between satisfaction and behavior remains unclear, it appears that youths' perceptions of the stability of their services plays a role in their acting out. It was concluded that youths' feelings about their services can provide meaningful information for researchers and service providers.     

Speech rhythm alterations in Spanish-speaking individuals with Alzheimer’s disease

Rhythm is the speech property related to the temporal organization of sounds. Considerable evidence is now available for suggesting that dementia of Alzheimer’s type is associated with impairments in speech rhythm. The aim of this study is to assess the use of an automatic computerized system for measuring speech rhythm characteristics in an oral reading task performed by 45 patients with Alzheimer’s disease (AD) compared with those same characteristics among 82 healthy older adults without a diagnosis of dementia, and matched by age, sex and cultural background. Ranges of rhythmic-metric and clinical measurements were applied. The results show rhythmic differences between the groups, with higher variability of syllabic intervals in AD patients. Signal processing algorithms applied to oral reading recordings prove to be capable of differentiating between AD patients and older adults without dementia with an accuracy of 87% (specificity 81.7%, sensitivity 82.2%), based on the standard deviation of the duration of syllabic intervals. Experimental results show that the syllabic variability measurements extracted from the speech signal can be used to distinguish between older adults without a diagnosis of dementia and those with AD, and may be useful as a tool for the objective study and quantification of speech deficits in AD.     

Expressive prosodic patterns in individuals with Alzheimer's disease

This paper describes a useful technique for quantifying the degree of speech deficits in dementia of GDS 4 Alzheimer's type (DAT). Production of prosodic speech in DAT patients and healthy older controls was analysed using variation in fundamental frequency (F0) measures on a reading task. The prosogram computational model was used to analyze the prosodic contours of the speech samples, using melodic styling of F0 based on perceptual principles and prominence detection of spectral and amplitude fluctuations in the speech signal. Results revealed significant differences in most of these prosodic parameters among the DAT group. Normal pitch variation in speech and variations in syllable timing were reduced in the DAT group, these features cause "flat" speech prosody in these patients. These speech parameters may have diagnostic and prognostic value for Alzheimer's disease and therefore could be a useful aid in clinical trials.