Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Unaltered ethical standards for individual physicians in the face of drastically reduced resources resulting from an improvised nuclear device event

When disaster disrupts healthcare and other systems, the ethical allocation of resources should follow principles of justice, defined as fairness, established for normal clinical practice. Standards of clinical practice may be altered during disaster, but ethical standards must remain centered on prioritizing the treatment of patients according to need and the effectiveness of treatment. Should resources become extremely limited, it is fair to restrict their use to patients who have the highest needs, provided that the intervention is effective. When resources become more available, patients with lower priority can be increasingly accommodated.     

What makes depressed people feel worse? A cross-cultural replication

Fifty non-patient Spanish adults in Valencia were asked in open-ended interviews, “when you're feeling depressed, what sort of things can make you feel worse?” Their responses were content analysed and compared to the similar data reported by Rippere (1980) for British subjects. As hypothesized, the English-speaking subjects showed a higher ratio of consensual to non-consensual items. They also produced more responses. Qualitative analysis of the two pools of items showed both characteristic similarities and differences. A corpus of situations which appear to make depressed people feel worse is derived from the items common to the Spanish and British data.     

Assimilation Setbacks as Switching Strands: A Theoretical and Methodological Conceptualization

This paper offers a theoretical and methodological formulation of setbacks in the process of assimilation of problematic experiences in psychotherapy. It is based on a series of theory-building case studies, in which case observations were used to modify and confirm an evolving understanding. Assimilation typically follows a sawtoothed progression in which advances alternate with setbacks. Research has identified two main types of setbacks, called exceeding the therapeutic zone of proximal development, and the balance strategy, which occur under systematically different conditions. Both types of setbacks can be understood as switching strands within a problematic theme. This formulation defines and elaborates the methodological concepts of topic, theme, and strand, as well as the underlying theoretical concepts of internal voices and sub-voices. These are illustrated with examples from a clinical case. This elaboration of the assimilation model is related to other perspectives that emphasize people’s multiplicity of internal voices and used to suggest further studies.     

Against Levinas’ messianic politics: a polemic

Blamelessly, most commentators attempt to deduce the political theory of Levinas from his interhuman philosophy. In contrast to the perceived state of ethical life in contemporary politics, the attractiveness of the asymmetric obligations owed by the ego to the Other make the deductive project seem urgent. But an inductive analysis of Levinas’ philosophy yields troubling prerequisites, including rigorous theocracy and a form of sociability in which no epistemological clarity is permitted that could determine in situ interpersonal duties. Such unfamiliar politics enable the celebrated ethical relation of self for the Other. Designed as a polemic with the presumption that politics not ethics is first philosophy, the insights of the inductive analysis of Levinas’ thought will come as no surprise to observers who worry that power and sovereignty cannot be summarily excluded from social or even ethical relations.     

Rotating objects to determine orientation, not identity: evidence from a backward-masking/dual-task procedure

The effects of picture-plane rotations on times taken to name familiar objects (RTs) may reflect a process of mental rotation to stored viewpoint-specific representations: the rotate-to-recognize hypothesis. Alternatively, mental rotation might be used after stored object representations are activated by a misoriented stimulus in order to verify a weak or distorted shape percept: the double-checking hypothesis. We tested these two accounts of rotation effects in object recognition by having subjects verify the orientations (to within 90 degrees) and basic-level names of 14-msec, backward-masked depictions of common objects. The stimulus-mask interval (SOA) varied from 14 to 41 msec, permitting interpolation of the SOA required for 75% accuracy (SOAc). Whereas the SOAc to verify orientation increased with rotation up to 180 degrees, the SOAc to verify identity was briefer and asymptoted at approximately 60 degrees. We therefore reject the rotate-to-recognize hypothesis, which implies that SOAc should increase steadily with rotation in both tasks. Instead, we suggest that upright and near-upright stimuli are matched by a fast direct process and that misoriented stimuli are matched at a featural level by a slightly slower view-independent process. We also suggest that rotation effects on RTs reflect a postrecognition stage of orientation verification: the rotate-to-orient hypothesis, a version of double-checking that also explains the well-known reduction in orientation effects on RTs when naming repeated objects.     

An introduction to the cognitive therapy of evaluation-[1]

This paper introduces a new cognitive therapy which is evolving from the theoretical background of general semantics theory. This therapy is being tested since 1985 with several samples, the results being favorable and promising. Nevertheless, only its theoretical rational and clinical background will be introduced. Subsequently, the cognitive therapy of evaluation will be defined, and its main therapeutic ingredients described; finally, its differences and similarities with current cognitive therapies will be highlighted.     

Mapping Aggression and Hegemony in the Neoliberal Era

I appreciate the opportunity to engage in this virtual dialogue with Dorothy Evans Holmes and Eyal Rozmarin, both of whom in this issue offer thoughtful discussions of my paper that in some instances questioned and in others expanded my analysis of neoliberal hegemony and subjectivity. My response to their commentaries touches on the following themes: the connection between instincts and hegemonic ideology and discourses; the nature of neoliberal culture in light of the history of group violence, sacrifice, and scapegoating; and the role of nostalgia in critical interpretations of neoliberal society and its vicissitudes. I also offer an addendum to my paper, written before the 2016 election, to comment on how neoliberalism produced the current political crisis, in which social malaise has been punctured by authoritarian politics, populist activism, and ideological polarization.     

The transfer of Crel contextual control (same,opposite, less than,more than) through equivalence relations

According to Relational Frame Theory (RFT) C_rel denotes a contextual stimulus that controls a particular type of relational response (sameness, opposition, comparative, temporal, hierarchical etc.) in a given situation. Previous studies suggest that contextual functions may be indirectly acquired via transfer of function. The present study investigated the transfer of C_rel contextual control through equivalence relations. Experiment 1 evaluated the transfer of C_rel contextual functions for relational responses based on sameness and opposition. Experiment 2 extended these findings by evaluating transfer of function using comparative C_rel stimuli. Both experiments followed a similar sequence of phases. First, abstract forms were established as C_rel stimuli via multiple exemplar training (Phase 1). The contextual cues were then applied to establish arbitrary relations among nonsense words and to test derived relations (Phase 2). After that, equivalence relations involving the original C_rel stimuli and other abstract forms were trained and tested (Phase 3). Transfer of function was evaluated by replacing the directly established C_rel stimuli with their equivalent stimuli in the former experimental tasks (Phases 1 and 2). Results from both experiments suggest that C_rel contextual control may be extended via equivalence relations, allowing other arbitrarily related stimuli to indirectly acquire C_rel functions and regulate behavior by evoking appropriate relational responses in the presence of both previously known and novel stimuli.