Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Religious Pluralism in Malaysia: the Journey of Three Prime Ministers

The challenges posed by religious pluralism have become central to any understanding of the complex dynamics of ethnically and religiously diverse societies. Malaysia is no exception. This article examines how recent Malaysian governments have handled these challenges. It situates government actions and pronouncements against the backdrop of Malaysia's colonial and pre-colonial history. The focus is on the declaratory and operational policies of three successive prime ministers (Mahathir, Abdullah and Najib). Careful analysis of this tumultuous period, which has seen the increasing assertiveness of public Muslim discourse, enables us to chart the obstacles to inter-religious harmony that policymakers have had to address. Several questions are at the core of the article: How did each of these leaders handle the emerging crisis of religious pluralism, which is closely entwined with ethnic pluralism? Did their actions match their rhetoric? Taken as a whole, this 15-year period reveals important elements of change and continuity.     

大学二年级学生人际宽恕与报复心理及其与抑郁的关系研究

采用沉思量表、报复动机量表、宽恕倾向量表、宽恕态度量表和流调中心用抑郁量表对236名大二学生进行问卷调查,综合探讨大学生人际宽恕和报复心理及其与抑郁的关系。研究发现:(1)男大学生的报复倾向显著高于女大学生。(2)宽恕倾向与报复倾向及对侵犯的沉思程度显著负相关。沉思程度和抑郁显著正相关。(3)沉思程度和宽恕倾向对抑郁分别具有显著的正向和负向的预测作用。(4)大学生的宽恕倾向和宽恕态度的相互作用以及宽恕倾向和报复倾向之间的交互作用对抑郁均没有显著预测作用。     

Dyslexia and the school counsellor: A Maltese case study

Aim: This paper seeks to understand whether Maltese school counsellors are equipped to deal with dyslexic clients, considers whether specific strategies need to be used, and what positive effects, if any, counselling has on these clients. Previous studies: A literature review on self-concept and techniques on how to improve the self-concept of children with Learning Disabilities (LD)/Specific Learning Difficulties (SpLD) will place the current study in context. Method: Questionnaires (available from the authors on request) were distributed to all school counsellors on the island and analysed using content analysis. Findings: Findings from respondents indicate a need for more training, evidence-based knowledge of specific techniques when dealing effectively and successfully with dyslexic clients, specific specialised training to understand dyslexic clients and that counselling has a positive effect on dyslexic clients.     

The ‘German Fathers’ of the Theological Turn in Phenomenology: Scheler,Reinach, Heidegger

This essay returns to the origins of the phenomenology of religion, offering an introduction to and a discussion of seminal contributions to the field. Three figures are examined: Max Scheler, Adolf Reinach and the early Martin Heidegger, who are presented as the ‘German Fathers’ of the phenomenology of religion. Each conducted a radical foray into the religious life‐world, sometimes in accord with the project of their Master Edmund Husserl, sometimes opposing or radically revising his project, but typically developing new methods and proposing radical insights. They attempted to define the proper attitude a phenomenologist – who might possibly also be a religious person – should adopt in the face of phenomena and lived experiences clearly beyond the ordinary. This enterprise led to heated debates and a rich analysis described here.     

Nudges and signposts: The effect of smart defaults and pictographic risk information on retirement saving investment choices

The authors tested two interventions to improve retirement savings investment decisions. In an incentive‐compatible experiment, 459 participants engaged in a task simulating their working life. Periodically during the simulation, participants chose between different investment options. The authors examined the effectiveness of a “nudge” by manipulating the default option and the effectiveness of a “signpost” by manipulating the display of a pictograph summarizing the expected return of each option. Participants often followed the default option, particularly when it was “smart” (i.e., became more conservative as retirement approached) and when presented together with dynamic pictographs (i.e., updated each year assuming the investment was held until retirement). Those most likely to make optimal choices (i.e., consistent with the life cycle model) were presented with a smart default or dynamic pictographs. These findings reveal how different choice architecture interventions can be used to positively influence behavior. Retirement funds and regulators can support retirement savings decisions by the provision of smart defaults and better risk information in the form of pictographs.     

Is Adolescent Bullying an Evolutionary Adaptation?

Bullying appears to be ubiquitous across cultures, involving hundreds of millions of adolescents worldwide, and has potentially serious negative consequences for its participants (particularly victims). We challenge the traditionally held belief that bullying results from maladaptive development by reviewing evidence that bullying may be, in part, an evolved, facultative, adaptive strategy that offers some benefits to its practitioners. In support of this view, we draw from research that suggests bullying serves to promote adolescent bullies' evolutionarily-relevant somatic, sexual, and dominance goals, has a genetic basis, and is widespread among nonhuman animals. We identify and explain differences in the bullying behavior of the two sexes, as well as when and why bullying is adaptive and when it may not be. We offer commentary on both the failures and successes of current anti-bullying interventions from an evolutionary perspective and suggest future directions for both research and anti-bullying interventions.     

Information processing bias against emotional facial expressions in social anxiety

The present study examined whether information processing bias against emotional facial expressions is present among individuals with social anxiety. College students with high (high social anxiety group; n  = 26) and low social anxiety (low social anxiety group; n  = 26) performed three different types of working memory tasks: (a) ordering positive and negative facial expressions according to the intensity of emotion; (b) ordering pictures of faces according to age; and (c) ordering geometric shapes according to size. The high social anxiety group performed significantly more poorly than the low social anxiety group on the facial expression task, but not on the other two tasks with the nonemotional stimuli. These results suggest that high social anxiety interferes with processing of emotionally charged facial expressions.