Stress-induced Fos-like Immunoreactivity in the Pons and the Medulla Oblongata of Rats

Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response.     

Cholinergic rebound after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats: implications for psychiatric treatment.

When lithium serum levels were within the (human) therapeutic range, young and old adult male and female rats (housed singly or in groups) all displayed faster limbic seizure onset times in response to a muscarinic cholinergic agonist (pilocarpine 20 mg/kg) if a single systemic dosage of chlorpromazine was injected 24 hours previously. The effect was comparable to injecting an additional 10 mg/kg of pilocarpine. These results strongly suggest that cholinergic rebound from chlorpromazine administrations during lithium treatment could facilitate subclinical electrical lability and very localized neuronal necrosis within the limbic system of clinical patients, resulting in normalization of psychiatric symptoms.     

The Development,Psychometric Analyses and Correlates of a Self-Report Measure on Disorganization and Role Reversal

A limited number of measures assess young adults’ perceptions of childhood disorganized and controlling attachment, and although they are empirically strong, the use of these measures can be time consuming and financially straining. The current study aimed to add to the attachment literature by developing a self-report measure, the Childhood Disorganization and Role Reversal Scale (CDRR), to assess for the complexity of those attachment constructs in young adults. This study aimed to assess the psychometric properties of the CDRR using two separate samples of 750 and 656 undergraduate students (601 females; M_age?=?18.68, 66.4% Caucasian; 531 females; M_age?=?18.68 years, 63.6% Caucasian; respectively), and a community sample of 96 participants (81 females, M_age?=?19.27, 65.6% Caucasian). The results of the Principal Component Analysis (PCA) revealed a four-factor structure for both CDRR parent versions. The CDRR mother version includes the Disorganization/Punitive, Mutual Hostility, Affective Caregiving, and Appropriate Boundaries scales, while the CDRR father version includes the Disorganization, Affective Caregiving, Appropriate Boundaries, and Punitive scales. Overall, support was provided for the psychometric properties of the CDRR. For instance, the CDRR scales demonstrated adequate structural stability (confirmatory factor analyses), internal consistency (Cronbach’s coefficient alphas ranged from .78–.95 for mother scale, and .75–.96 or father scale), temporal reliability (intraclass correlation coefficient ranged from .68–.89 for mother scale, and .69–.87 for father scale), criterion-related validity, convergent validity, and discriminant validity. The CDRR will assist researchers in broadening the understanding of psychological outcomes of disorganized and controlling attachment representations in young adulthood.     

Correlates of attachment at age 3: construct validity of the preschool attachment classification system

This study examined correlates of attachment at age 3 to further validate preschool separation-reunion measures. Three-year-olds (N = 150) and their mothers participated in a separation-reunion protocol, the Preschool Attachment Classification System (PACS: J. Cassidy & R. S. Marvin with the MacArthur Working Group on Attachment, 1992), and a mother-child interaction session during a laboratory visit. Mothers also completed psychosocial measures and, along with teachers, evaluated child behavior problems. The secure and disorganized groups received, respectively, the highest and lowest interaction scores. Disorganized children showed a higher level of teacher-reported externalizing and internalizing problems than did secure children. Mothers of insecure children reported higher child externalizing (all insecure groups) and internalizing (avoidant group) scores, more personal distress related to emotional bonding (disorganized group), childrearing control (ambivalent group), and child hyperactivity (avoidant group). Results strongly support the validity of the PACS as a measure of attachment in 3-year-olds.     

Self-determination: a buffer against suicide ideation

Self-determination was examined as a protective factor against the detrimental impact of negative life events on suicide ideation in adolescents. It is postulated that for highly self-determined adolescents, negative life events have a weaker impact on both hopelessness and suicide ideation than for non-self-determined adolescents. In turn, hopelessness is hypothesized to generate less suicide ideation for highly self-determined individuals. Results from multigroup analyses confirm that both the direct and indirect links between negative life events and suicide ideation were significantly weaker among participants high in self-determination. The protective role of self-determination against negative life events is discussed.     

On passion and moral behavior in achievement settings: The mediating role of pride

The Dualistic Model of Passion (Vallerand et al. in J Person Soc Psychol 85:756–767, 2003) distinguishes two types of passion: harmonious passion (HP) and obsessive passion (OP) that predict adaptive and less adaptive outcomes, respectively. In the present research, we were interested in understanding the role of passion in the adoption of moral behavior in achievement settings. It was predicted that the two facets of pride (authentic and hubristic; Tracy and Robins in J Person Soc Psychol, 92:506–525, 2007) would mediate the passion-moral behavior relationship. Specifically, because people who are passionate about a given activity are highly involved in it, it was postulated that they should typically do well and thus experience high levels of pride when engaged in the activity. However, it was also hypothesized that while both types of passion should be conducive to authentic pride, only OP should lead to hubristic pride. Finally, in line with past research on pride (Carver et al. in J Res Person 44:698–703, 2010; Tracy et al. in Self Identity 8:196–213, 2009), only hubristic pride was expected to negatively predict moral behavior, while authentic pride was expected to positively predict moral behavior. Results of two studies conducted with paintball players (N = 163, Study 1) and athletes (N = 296, Study 2) supported the proposed model. Future research directions are discussed in light of the Dualistic Model of Passion.     

农村卫生改革面临的深层次的矛盾和问题

对健康缺失阻碍农村经济发展没有清楚的认识,是制约农村卫生发展的重要因素.农村卫生纯属公共品范畴,理所当然是政府实现公共服务目标的基本职责.我国财政整体分配格局不合理,是农村卫生投入不足的基本原因.农村卫生保健制度一个非常突出的问题,是基本模式的选择,忽视关键制度的设计与调整.卫生院是医疗服务的提供者,是合作医疗保障制度的利益主体,同时又是合作医疗的组织者与管理者,不符合医疗保障制度的要求,同时也难以形成纠错的机制.     

Parenting stress,general distress,and coparenting quality: An Actor–Partner Interdependence Moderation Model

Mothers and fathers who experience parenting stress are more likely to show symptoms of distress, such as elevated levels of anxiety and/or depression. Identifying the buffering or exacerbating factors that might moderate the association between parenting stress and general distress can help inform theoretical models aimed at better understanding the reality faced by parents during challenging times, as well as improve intervention strategies. The objective of this study was to examine whether coparenting quality plays a moderating role in the association between parenting stress and general distress in parents of children in middle childhood. Eighty-one couples were asked to complete questionnaires pertaining to their levels of parenting stress, the quality of their coparenting relationship, and their symptoms of distress. Using an Actor–Partner Interdependence Moderation Model, our results revealed that elevated levels of parenting stress were associated with elevated levels of general distress, whereas higher scores of coparenting quality were associated with fewer symptoms of distress. Our results also showed a moderating role for coparenting quality in the association between actor parenting stress and actor/partner distress. These findings highlight the importance of pursuing the investigation of dyadic effects within personal relationships.     

Childhood Maltreatment and Prospectively Observed Quality of Early Care as Predictors of Antisocial Personality Disorder Features

Few studies have evaluated the separate contributions of maltreatment and ongoing quality of parent-child interaction to the etiology of antisocial personality features using a prospective longitudinal design. 120 low-income young adults (aged 18-23) were assessed for extent of ASPD features on the Structured Clinical Interview for Diagnosis-Axis II, for presence of maltreatment on the Conflict Tactics Scale, Traumatic Experiences Scale, and Adult Attachment Interview, and for referral in infancy to parent-infant clinical services. Fifty-six of these families had been studied longitudinally since the first year of life. In infancy, attachment disorganization and disrupted mother-infant interaction were assessed; in middle childhood, disorganized-controlling attachment behaviors were reliably rated. In kindergarten and second grade, behavior problems were assessed by teacher report. In cross-sectional analyses, maltreatment was significantly associated with ASPD features but did not account for the independent effect of early referral to parent-infant services on ASPD features. In longitudinal analyses, maternal withdrawal in infancy predicted the extent of ASPD features twenty years later, independently of childhood abuse. In middle childhood, disorganized attachment behavior and maladaptive behavior at school added to prediction of later ASPD features. Antisocial features in young adulthood have precursors in the minute-to-minute process of parent-child interaction beginning in infancy.