Frontal cortex grafts have opposite effects at different postoperative recovery times

We studied the effect of different postoperative times on the behavioral recovery following brain implants. Adult male rats received cortical tissue grafts 2 weeks after aspiration of the medial frontal cortex. Either 2 (Immediate Group) or 28 (Delay Group) days after grafting, the performance of these rats on a behavioral battery, comprising the Morris water maze task, forepaw use, and grooming, was compared to that of rats with similar lesions and postoperative recovery times but no grafts. Rats tested immediately after receiving implants performed better on the spatial navigation task than rats with similar lesions but no grafts. This improvement, however, was less than that shown by rats with lesions but no grafts permitted to recover for 28 days before testing. In contrast, in the Delay Group, rats with grafts were more greatly impaired than were their operated controls. Neither lesions nor grafts affected grooming although the Immediate Group with grafts were significantly more impaired in using their forepaws during feeding than were any of the other groups. These results lead us to conclude that differing postoperative recovery times and task requirements may account for some of the inconsistent results of the influence of brain grafts on behavioral recovery reported in the literature. We also conclude that cortical tissue implants can have two effects with different time courses and opposite net behavioral effects.     

The diplomatic career of Mircea Eliade: A response to Adriana Berger

Adriana Berger has attacked Mircea Eliade's connection with the Romanian right-wing movement, the Iron Guard, or Legion of the Archangel Michael. Her article ‘Fascism and religion in Romania’, makes much of certain British Foreign Office documents which I have inspected in detail. Not only do these documents fail to corroborate Berger's conclusions but they cast real doubt on Berger's critical detachment. Her claim that Eliade was detained in England because of his political activities on behalf of the Iron Guard, and also of Nazi Germany, is without foundation. Other insinuations which she has made about Eliade's political motivations are subject to alternative interpretations. Eliade undoubtedly was vehemently nationalist in his youth and gave some support to the Legion of the Archangel Michael. However, we must constantly guard against permitting our pre-existent judgements of nationalism and fascism to dictate our reading of historical event. Even if justified, prejudice is still prejudice and is not acceptable scholarship.     

Pharmacological treatment of affective disorders: A review and guide for the non-medical practitioner

Mental health professionals who lack medical training may also lack knowledge and understanding of the potential utility of medications in the treatment of emotional disturbance. They may also lack information regarding the effects and side-effects of medications which their clients may already be taking, or be uncertain when the nature of their client's situation suggests a psychiatric assessment regarding drug therapy. This paper offers an educational review in one such area: the pharmacological treatment of depression. It includes a brief review of theories regarding the aetiology of affective disorder, examines the methodes, mechanisms and efficacy of anti-depressants, and draws conclusions regarding the appropriate use of pharmacological treatment.     

The psychophysiology of combat-induced post-traumatic stress disorder in Vietnam veterans

The psychophysiological responses of heart rate (HR), systolic and diastolic blood pressure, skin conductance level and forehead electromyogram were compared during: rest, mental arithmetic and combat sounds of gradually increasing intensity for five groups of Ss: Vietnam veterans with post-traumatic stress disorder (PTSD); Vietnam veterans without PTSD but with comparable levels of combat experience; Vietnam veterans with other psychiatric disorders; Vietnam-era veterans; and nonveteran phobics. HR response to low-intensity combat sounds provided good discrimination between veterans with PTSD and the other groups and seems to resemble a conditioned emotional response.     

Effects of neonatal forebrain noradrenaline depletion on recovery from brain damage: performance on a spatial navigation task as a function of age of surgery and postsurgical housing

The experiments examined the contributions of forebrain noradrenaline and environmental enrichment to recovery of place navigation ability in rats after hemidecortication in infancy or adulthood. Noradrenaline depletion did not affect recovery from neonatal hemidecortication, although the early hemidecortications did allow sparing of function relative to adult operates. Noradrenaline depletion also failed to attenuate the positive effects of enriched housing on otherwise normal rats. Noradrenaline depletion did retard recovery of adult hemidecorticate rats housed in standard laboratory cages, but it did not retard recovery of adult hemidecorticate rats housed in enriched environments. The results suggest that noradrenaline is importantly involved in enhancing recovery from brain damage when other sources of compensation (e.g., neonatal injury, enriched environment) are absent.     

Postsurgical enrichment aids adult hemidecorticate rats on a spatial navigation task

The effect of environmental enrichment on normal rats, rats that received hemidecortication at birth, and rats that received hemidecortication when adult was studied in the Morris water task, which is a spatial navigation task requiring the use of distal cues for successful performance. Enrichment was achieved by housing the rats for 90 days in a large outdoor compound that was designed to model a natural environment. Adult hemidecorticated lab-raised rats were severely impaired in the acquisition of the task but neonatally hemidecorticated rats, although also impaired, showed significant sparing. Postsurgical, but not presurgical, enrichment of adult hemidecorticated rats significantly enhanced their recovery. Enrichment had little effect on neonatally decorticated rats or on normal rats. Although there were no gross anatomical changes associated with enrichment, the paradigm provides both a robust phenomena and a cortically dependent task that is ideal for investigating the processes in the remaining intact hemisphere that must support recovery.     

A technique for the construction of discrete dichotic stimulation material

Procedures are described for the generation, synchronization. and accurate spacing of discrete dichotic stimulation material. A suggested standard definition of interpair interval is proposed.