Stress-induced Fos-like Immunoreactivity in the Pons and the Medulla Oblongata of Rats

Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response.     

Blameworthiness as Deserved Guilt

It is often assumed that we are only blameworthy for that over which we have control. In recent years, however, several philosophers have argued that we can be blameworthy for occurrences that appear to be outside our control, such as attitudes, beliefs and omissions. This has prompted the question of why control should be a condition on blameworthiness. This paper aims at defending the control condition by developing a new conception of blameworthiness: To be blameworthy, I argue, is most fundamentally to deserve to feel guilty. Being blamed by someone else is not necessarily harmful to the wrongdoer. The blame might not be expressed, or the wrongdoer might not care. But to blame oneself necessarily involves suffering. This conception of blameworthiness explains why the control condition should obtain: We are morally blameworthy for A only if A was (directly or indirectly) under our control because (a) to be blameworthy is to deserve to feel guilty, (b) to feel guilty is to suffer, and (c) one deserves to suffer for A only if A was under one’s control.     

Long Sickness Absence Differences Between Natives and Immigrant Workers: The Role of Differences in Self-reported Health

The limited empirical evidence on sickness absence among immigrants indicates that non-Western immigrants have a higher incidence of sickness-related absence than natives. The purpose of this article is to examine whether health is a contributing factor to the immigrant-native sickness absence gap. The present article makes use of two data sources: register data (FD-trygd) with labour market and long-term sickness absence information linked to a cross-section questionnaire survey on health: The Oslo Health Study, which was conducted in 2000–2001 (N?=?14,114). The findings in this article show that non-Western immigrants have a higher incidence of long-term sickness absence than natives. For both women and men, the differences in long-term sickness absence between non-Western immigrants and natives can be explained by poorer self-reported health among immigrants.     

The measurement of self-esteem among Korean Americans: a cross-ethnic study

Studies have indicated that Asians' self-esteem is generally lower than other ethnic groups'. The authors hypothesized that an item response bias would result in lower self-esteem scores for Asians. Specifically, it was hypothesized that positively worded items would be rated lower by Korean Americans but that there would be no difference on negatively worded items across ethnic groups. The hypothesis was tested using 214 individuals diagnosed with schizophrenia who were Korean American, Caucasian, African American, or Latino. Results supported the hypothesis. Korean Americans had significantly lower self-esteem scores than the other 3 groups on all positively worded items but were no different from the other groups on negatively worded items. Additional analyses showed modest support for the cross-cultural construct equivalence of this measure of self-esteem.     

Conservation of Weight with the Mentally Retarded

Institutionalized retardates (N = 54), Public School retardates (N = 65), and a group of normal subjects (N = 112) were compared at several mental age levels on three conservation of weight tasks. The functioning of normal subjects was higher at each mental age level. An analysis of covariance was performed on the number of correct responses on the three tasks, covarying mental age, and not including any normal subjects above 13 years 11 months in mental age (N = 82). Normal subjects conserved significantly more often than either retardate group in the covariance analysis also.     

Longitudinal construct validity of Brief Symptom Inventory subscales in schizophrenia

Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times parameter constraints, with the homogeneous model being the least constrained, followed by the 2-parameter GRM and 1-parameter GRM. Results show that 4 subscales (Interpersonal Sensitivity, Hostility, Paranoid Ideation, Psychoticism) were consistent with the 1-parameter GRM, and 5 subscales (Somatization, Obsessive-Compulsive, Depression, Anxiety, Phobic Anxiety) were consistent with the 2-parameter GRM. There is evidence that the 9 subscales may be validly used to study change in single constructs over time.     

What Factors Influence the Decision to Share Suicidal Thoughts? A Multilevel Social Network Analysis of Disclosure Among Individuals with Serious Mental Illness

Nondisclosure of suicidal thoughts limits suicide risk management. Consistent with disclosure models for other stigmatized statuses, understanding suicidal disclosure requires accounting for features of the discloser (individual factors) and the discloser–recipient relationship (relational factors). In a sample of 30 adults with schizophrenia, bipolar disorder, or major depressive disorder (Level 2) who nominated 436 social network members (Level 1), we examined disclosure patterns and identified individual and relational correlates of disclosure intent. Most individuals disclosed in the past (77%; n = 23) and all intended on disclosing (100%; n = 30). Disclosure was highly selective, with 14% (n = 62) of network members identified as prior confidants and 23% (n = 99) identified as intended confidants. Multilevel modeling indicated that relational factors were more central to disclosure than individual factors. Network members who were prior confidants and who provided social support were attractive targets for intended disclosure. Our findings suggest that “targeted” gatekeeper training may be a promising strategy and reveal relational characteristics to identify “high‐probability confidants.”