Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

A critical review of psychotherapy outcome studies with adolescents: 1978-1988

Although interest in identifying effective psychotherapies for adolescent mental health problems has increased dramatically in the last decade, there have been few attempts to summarize and integrate the recent empirical literature on psychotherapy outcomes with adolescents. The present paper reviews the methods and findings of adolescent psychotherapy outcome studies published from 1978 to 1988. Evaluations of individual psychotherapy with adolescents generally reveal positive short-term outcomes, but long-term outcomes are still to be determined. Evaluations of systemic therapies (especially family therapy) with adolescents often reveal positive outcomes that are maintained over extended follow-up periods. Recommendations are presented for improving the methodology of future psychotherapy outcome studies with adolescents.     

Use of the family adaptability and cohesion evaluation scales in child clinical research

Although the FACES has become a widely used instrument for assessing children's family relations, the possible linearity vs. curvilinearity of its cohesion and adaptability scales has been treated inconsistently by investigators. This study evaluated whether samples of adolescent repeat offenders, young adult prisoners, and adolescent nonoffenders were discriminated better by a linear or curvilinear treatment of the FACES scores. Between-groups comparisons showed that significant effects were observed for each of the three curvilinear measures (cohesion-curvilinear, adaptability-curvilinear, distance-from-center) and only one of the two linear measures (cohesionlinear). These findings support the superiority of a curvilinear treatment of the FACES. In light of these findings, it is suggested that investigators who use FACES evaluate the linearity of the scales and determine whether a linear or curvilinear treatment of the data produces more meaningful results.     

Development of the concept of family in elementary school children

Two studies were conducted to examine the relation of age, gender, and family structure to children's understanding of the concept of family. In Study 1,387 children in Grades 1 through 6 were asked to classify various groupings of individuals as constituting or not constituting a family. Results showed both age and gender differences in children's conceptions of families: Younger children, especially boys, generally used concrete, absolute criteria for defining a family; younger girls were similar to older children in that they were more likely to employ abstract, relational criteria for family definition. Results also showed that children's own family structure was not related to their family definitions. In Study 2, 64 children from the original sample were given a measure of cognitive ability to examine whether differences in cognitive development or differences in socialization were a likely source of younger girls' more advanced understanding. Gender differences in cognitive ability did not emerge, suggesting that the gender effects in Study 1 reflected differences in the socialization of boys and girls. Implications of the findings for understanding children's reactions to family disruption are discussed.     

The family relations of female juvenile delinquents

This study evaluated the assumption that the family relations of female delinquents are more dysfunctional than those of male delinquents. In a 2 × 2 (gender by delinquency status) design, 32 intact families were matched on demographic variables, and the male and female delinquents were matched on arrest data. Mothers, fathers, and adolescents were administered a selfreport personality inventory and were observed during a family interaction task. Consistent with the extant literature, families of delinquents had low rates of facultative information exchange and delinquent adolescents were more dominant toward their mothers than were well-adjusted adolescents. It was also observed that fathers of delinquents were more dominant toward their wives than were fathers of well-adjusted adolescents. In regard to the primary purpose of the study, it was observed that mother-adolescent dyads and parents in families of female delinquents had higher rates of conflict than their counterparts in families of male delinquents. In addition, the fathers of female delinquents were more neurotic than the fathers of male delinquents. These findings provide some support for the view that the families of female deliquents are especially dysfunctional.This research was supported by funding to the Department of Psychology at Memphis State University granted through the Centers of Excellence Program of the State of Tennessee. We gwratefully appreciate the cooperation of Judge Kenneth Turner of Memphis Juvenile Court, and of George Relyea, who has provided statistical consultation over the years.     

The Effective Treatment of Juveniles Who Sexually Offend: An Ethical Imperative

This article raises serious concerns regarding the widespread use of unproven interventions with juveniles who sexually offend and suggests innovative methods for addressing these concerns. Dominant interventions (i.e., cognitive-behavioral group treatments with an emphasis on relapse prevention) typically fail to address the multiple determinants of juvenile sexual offending and could result in iatrogenic outcomes. Methodologically sophisticated research studies (i.e., randomized clinical trials) are needed to examine the clinical and cost-effectiveness of cognitive-behavioral group interventions, especially those delivered in residential settings. The moral and ethical mandate for such research is evident when considering the alternative, in which clinicians and society are willing to live in ignorance regarding the etiology and treatment of juvenile sexual offending and to consign offending youths to the potential harm of untested interventions. Encouraging signs of a changing ethical climate include recent federal funding of a randomized clinical trial examining treatment effectiveness with sexually offending youths and the introduction of separate (i.e., developmentally informed) clinical and legal interventions for juvenile versus adult sexual offenders.