Parental communication appears not to be an effective strategy to reduce smoking in a sample of Dutch adolescents

This longitudinal study examined the reciprocal effects of the frequency of parent–adolescent communication on tobacco-related issues (smoking-specific communication), and adolescents’ smoking. Participants were 428 Dutch older and younger siblings between 13 and 16 years old. Smoking-specific communication did not affect youth smoking in general; however, among younger, but not older, siblings, smoking-specific communication was associated with a higher likelihood of smoking over time. In addition, when adolescents already smoked parents started to talk more frequently about smoking-related issues with their older and younger adolescents later on. Neither the quality of smoking-specific communication, the quality of parent–adolescent relationship, nor parental smoking moderated these reciprocal effects. In conclusion, prevention campaigns encouraging parents to undertake smoking-specific communication might not be desirable.     

Learning and adult neurogenesis: survival with or without proliferation?

Recent high quality papers have renewed interest in the phenomenon of neurogenesis within the adult mammalian brain. Many studies now show that neurogenesis can be modulated by environmental factors including physical activity, stress, and learning. These findings have considerable implications for neuroscience in general, including the study of learning and memory, neural network plasticity, aging, neurodegeneration, and the recovery from brain injury. Although new light has been shed on this field, many contradictory findings have been reported. Here we propose two principle issues which underlie these inconsistencies, with particular focus on the interaction between learning and neurogenesis. The first issue relates to the basic methodology of measuring the generation of new brain cells, i.e., proliferation, as compared to survival of the newly made cells. Mostly, measures of neurogenesis reported are a combination of proliferation and survival, making it impossible to distinguish between these separate processes. The second aspect is in regards to the role of environmental factors which can affect both proliferation and survival independently. Especially the interaction between stress and learning is of importance since these might counteract each other in some circumstances. Reviewing the literature while taking these issues into account indicates that, in contrast to some findings, cell proliferation in the dentate gyrus of the hippocampus as a result of learning cannot be ruled out yet. On the other hand, increased survival of granule cells in the dentate gyrus as a result of hippocampal-dependent learning has been clearly demonstrated. Moreover, this learning-induced survival of granule cells, which were born before the actual learning experience, might provide a molecular mechanism for the 'use it or lose it' principle.     

Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action

In this study, the effect of the selective phosphodiesterase type 4 (PDE4) inhibitor rolipram on memory performance was investigated using the object recognition task. First, three doses of rolipram (0.01, 0.03 or 0.1 mg/kg) were tested with a 24h delay between the learning (T1) and the test (T2) trial. Doses of rolipram were injected at different time points (30 min before T1, immediately after T1 or 3 h after T1). In a second experiment, the effects of rolipram (0.03, 0.1 or 0.3 mg/kg) were tested in combination with scopolamine (0.1 mg/kg) applying a 1 h delay between trials. Both substances were administered 30 min before T1. Using a 24h interval, rolipram showed an improvement in long-term memory performance when injected 3 h after T1 at a dose of 0.03 mg/kg. Further, rolipram reversed the scopolamine-induced short-term memory deficit at a dose of 0.1 mg/kg. Although the improved memory performance in both conditions is likely to be explained by elevated cAMP levels, two separate working mechanisms might explain these effects.     

The Props are Falling Down and We Want to Make Music: A Narrative Perspective on Organisations in Transition (Violins/Violence in Organisations)

While South African society finds itself in the throes of political changes, therapists working within organisations in transition find themselves challenged by the turbulence of transformation. The authors are a group of therapists attempting to understand, from a narrative perspective, the organisational context within which they work. This paper recounts the processes around the design, implementation, and outcomes of a workshop on this theme. The main body of the paper consists of a letter that was sent to participants after the workshop. The reader is invited to join collaboratively in our reflections so as to continue an open-ended, creative process.     

Unhindered Spatial Processing During Route Memorization is Required to Maximize Both Spatial and Verbal Route Knowledge

To successfully remember a route in a physical environment, individuals are believed to process and store both verbal and spatial information of that route. The present study tested whether both spatial and verbal contents are necessary to form an effective route memory. For that purpose, route learning was performed in three concurrent task conditions (spatial, verbal and control) and appraised at two moments in time, via three route memory tests (spatial, verbal and spatial–verbal). Results showed that route memory generally improved across time and that spatial information was remembered better than verbal information. The concurrent spatial condition resulted in lower retention scores of both spatial and verbal route knowledge. These results suggest that effective spatial processing forms a scaffold without which long‐term retention lacks detail of both spatial and verbal route knowledge. It is discussed how these findings add to understanding spatial memory of routes. Copyright © 2013 John Wiley & Sons, Ltd.     

Delinquent Development in Dutch Childhood Arrestees: Developmental Trajectories,Risk Factors and Co-morbidity with Adverse Outcomes during Adolescence

Heterogeneity of re-offending patterns was studied in a group of 287 male early onset offenders who were first arrested before age 12. By combining data on the frequency and severity of offending as registered by the police over a 5-year follow-up period, three delinquent trajectories were identified; low, escalating, and high level re-offenders. Predicting group membership by individual and environmental characteristics known to the police at the time of the first arrest proved difficult. Compared to low level re-offenders, escalators were older and more often came from disadvantaged neighborhoods. High level re-offenders were also older at onset, more often had a non-Western ethnic background, and initially committed more vandalism. Furthermore, at the first police encounter, the police reacted more severely towards those who later became high level re-offenders. Finally, high and escalating re-offenders more often had other adverse outcomes, such as criminal victimization and Child Welfare Agency involvement.

Exploring Connections of the Supervisors in Supervision

Four therapists have worked closely in a professional support group. More recently attention has been given to the group processes and internal experiences of the group itself. An observation of the four members of this group is that the group process has allowed for peer validation, fortuitously resulting in their professional identities shifting and evolving. They have become curious about the interface between and the integration of personal and professional facets of the therapist's self. A resulting discovery has been that the very mechanisms which disconnect the therapist out there may serve to promote connection in the support group.     

Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms

A promising target for memory improvement is phosphodiesterase type 5 (PDE5), which selectively hydrolyzes cyclic guanosine monophosphate (cGMP). In rodents, PDE5 inhibitors (PDE5-Is) have been shown to improve memory performance in many behavioral paradigms. However, it is questioned whether the positive effects in animal studies result from PDE5 inhibition in the central nervous system or the periphery. Therefore, we studied the effects of PDE5 inhibition on memory and determined whether compound penetration of the blood-brain barrier (BBB) is required for this activity. Two selective PDE5-Is, vardenafil and UK-343,664, were tested in the object recognition task (ORT) in both a MK-801- and scopolamine-induced memory deficit model, and a time-delay model without pharmacological intervention. Compounds were dosed 30 min before the learning trial of the task. To determine if the PDE5-Is crossed the BBB, their concentrations were determined in plasma and brain tissue collected 30 min after oral administration. Vardenafil improved object recognition memory in all three variants of the ORT. UK-343,664 was ineffective at either preventing MK-801-induced memory disruption or time-dependent memory decay. However, UK-343,664 attenuated the memory impairment of scopolamine. Vardenafil crossed the BBB whereas UK-343,664 did not. Further, co-administration of UK-343,664 and scopolamine did not alter the brain partitioning of either molecule. This suggests that the positive effect of UK-343,664 on scopolamine-induced memory decay might arise from peripheral PDE5 inhibition. The results herein suggest that there may be multiple mechanisms that mediate the efficacy of PDE5 inhibition to improve memory performance in tasks such as the ORT and that these involve PDE5 located both within and outside of the brain. To further elucidate the underlying mechanisms, the cellular and subcellular localization of PDE5 needs to be determined.     

Sugar daddies and blessers: A contextual study of transactional sexual interactions among young girls and older men

This mixed method study aimed to gather a contextual understanding of the perspectives of young girls in South Africa with regard to transactional sexual interactions between older men and young girls. Two major narratives of the “sugar daddy” phenomenon have dominated the public discourse on the topic. One emphasises the girls' vulnerability and experience of victimisation, whereas the other highlights their role as social agents with control in such interactions. In this study, the participants acknowledged the heterogeneity among partners in such interactions, which suggests that the phenomenon of “sugar daddies” cannot be explained by a simple narrative. The girls' experiences form a continuum based on the degree of their individual control and the extent of their vulnerability in such an interaction. Contextual factors and social norms influence decisions and experiences in these interactions. The study concludes that these relationships form part of the girls' daily experiences of structural violence as well as gender inequality and can be regarded as a symptom of broader societal structures and norms. Quantitative data investigate the mental health status of the participants, whereas an essentialist/realist thematic analysis of qualitative data explores experiences and perceptions of the girls.     

Stress related changes in immunological and psychological variables induced by the preparation and defense of a PhD-thesis

Abstract

Results are reported from a field study on 47 healthy subjects preparing and defending a PhD-thesis in the Netherlands. Measurements before, about and after thesis defense are used to quantify the temporal effects of this perceived stressor on immunological and psychological variables. Moreover, multivariate analysis of variance for repeated measurements was used to explore a potential causal relationship between changes in immune variables and changes in psychological variables. Significant temporal effects were observed for the immunological variables, percentage CD4 cells (p = 0.037), the proliferative response to pokeweed mitogen (p = 0.040), concanavalin A 10 μg/ml (p = 0.010) and concanavalin A 40 μg/ml (p = 0.005) and the psychological variables, average subjective distress (p = 0.002), highest subjective distress (p = 0.000) and the coping strategy depressive reaction pattern (p= 0.02). No evidence was obtained for a causal relation between the immunological and psychological variables.