McEwen-Induced Modulation of Endocrine History: A Partial Review

In endless facets of physiology, there are points of homeostatic balance, such that too much or too litttle of something can both be deleterious (i.e., an "inverse U" pattern). This is particularly true when considering glucocorticoids (GCs), the adrenals steroid secreted during stress. In the first part of this paper, I review a number of realms in which a paucity and an excess of GCs are both damaging. Some findings are classical (for example, concerning GC effects upon body weight), while some are quite recent and have considerable implications for both physiology and pathophysiology (for example, inverse U's of GC actions in the realm of immunity and neuronal survival). The second part of the review considers the far thornier issue of how such inverse U's of GC actions are generated on a cellular and molecular level. One solution that has evolved, primarily in the hippocampus within the nervous system, involves the presence of two different types of receptors for GCs within the same cells; so long as the two receptors have very different affinities and mediate opposing effects on some cellular endpoint, an inverse U will emerge. The second solution, found in a number of peripheral tissues, involves GCs having opposing effects on the amount of some signal being generated (e.g., an immune cytokine) and the sensitivity of target tissues to that signal; under conditions that appear to be physiologically relevant, inverse U's emerge from this pattern as well. The final section of this review considers the enormous role played by Bruce McEwen in the emergence of this literature. I suggest that while much of this obviously has to do with the facts that have come from his group, another substantial contribution is from his steadying and supportive personality, the veritable embodiment of homeostatic balance.     

Considerations on using a lightpen-interactive system with young children

The lightpen is a simple interactive device allowing easy communication between a naive user and a computer. Very young children (4–6 years old) can use a lightpen interactively to pick out targets displayed on a VDU. Accuracy of target selection and stability of pointing with the lightpen was measured in these young children, and also in an older group of children (10–11 years old), who showed superior performance on both measures. In the younger group, both postural factors and physical fatigue sometimes affected lightpen handling. However, children of both age groups failed to compensate for parallax near the edges of the curved display screen. Recommendations are made for the programming and design of lightpen-interactive displays.     

Does augmented feedback from pedometers increase adults' walking behavior?

This study investigated whether feedback from pedometers motivated adults to increase their walking behavior. Participants (n =26) were enrolled in one of two 8-wk. "Walking for Fitness" classes. The study used a crossover design, such that Group 1 wore pedometers for the first 3 weeks (Feedback Condition) and sealed "disguised" pedometers for the last 3 weeks (No-feedback Condition). The order of feedback was reversed for Group 2. Analysis indicated that (a) neither group increased their walking behavior significantly over time and, (b) interactions between groups were not significant at Week 3 or 6, indicating that groups did not respond differently to feedback from the pedometers. If a motivational effect from pedometers exists, it may be small, dissipate before 3 wk., only work in combination with goal setting, or only motivate certain types of individuals.     

Age, marital satisfaction, and optimism as predictors of positive sentiment override in middle-aged and older married couples

This study examined whether positive sentiment override (greater positive appraisal of spouse's affiliative behavior than is warranted by observed behavior) occurred more frequently in older compared with middle-aged married couples and whether age differences were mediated by older adults' greater marital satisfaction when controlling for optimism. Participants included 270 middle-aged (40-50 years old) and older (60-70 years old) couples who discussed a marital disagreement and completed an errand task. Couples provided appraisals of their spouse's affiliation, and the authors coded affiliative interactions using the structural analysis of social behavior. Hierarchical multivariate linear modeling indicated that older husbands and wives viewed their spouse's behavior as more positive during disagreement interactions than did independent observers; in the errand task, only older wives demonstrated positive sentiment override. Age differences in positive sentiment override were mediated by marital satisfaction, even when controlling for optimism. The results are consistent with theories of emotion regulation, such as socioemotional selectivity theory, that suggest that older adults are biased toward the positive aspects of close relationships.     

Parent–Adolescent Collaboration: An Interpersonal Model for Understanding Optimal Interactions

Current parent–adolescent behavioral interaction research highlights the importance of three elements of behavior in defining adaptive interactions: autonomy, control, and warmth vs. hostility. However, this research has largely addressed the developmental needs and psychosocial outcomes of adolescents, as opposed to parents, with a focus on how parent and adolescent behaviors influence adolescent adaptation. This paper utilizes both adolescent and mid-life developmental research, as well as parent–adolescent interaction research, to introduce a model for conceptualizing parent–adolescent interactions as a transactional process in which both parental and adolescent development are considered. Further, ideas are presented describing how adaptive parent–adolescent interactions may change across adolescence. The concept of collaboration is proposed as a conceptual tool for assessing one form of adaptive parent–adolescent interactions. The structural analysis of social behavior (SASB) is presented as a model for studying the complex reciprocal processes that occur in parent–adolescent interpersonal processes.     

Developmental and sex-related differences in preschoolers' affective decision making

This study investigated developmental and sex-related differences in affective decision making, using a two-deck version of Children's Gambling Task administered to 3- and 4-year-old children. The main findings were that 4-year-old children displayed better decision-making performance than 3-year-olds. This effect was independent of developmental changes in inductive reasoning, language, and working memory. There were also sex differences in decision-making performance, which were apparent only in 3-year-old children and favored girls. Moreover, age predicted awareness of task and the correlation between the latter and decision-making performance was significant, but only in 4-year-old children. This study thus indicates that there is a remarkable developmental leap in affective decision making, whose effects are apparent around the age of 4, which according to our results, also marks the age when the correlation of declarative knowledge and decision-making performance becomes significant.     

Visual representation in analogical problem solving

Analogical reasoning has been shown to be effective in the process of solving Dunker’s radiation problem. The spatial nature of the solution to this problem suggests that a visually represented analogue should be particularly effective. However, recent work seems to indicate that a visual analogue does not assist in solving the radiation problem. This paper reports a detailed experimental analysis of the effectiveness of visually represented analogues to the radiation problem. The results show that visual analogues can be effective ff they represent the appropriate features of the problem-solution relationship. The paper also reports on the use of an appropriate visual representation within the problem as a facilitator of analogical reasoning. The results indicate that a visual representation within the problem can act as a facilitator of analogical reasoning, possibly by acting as a retrieval cue.     

Remediation of asyntactic sentence comprehension using a multimedia microworld

We report the evaluation of a new automated protocol for the treatment of asyntactic comprehension. This is a follow-up study to the "Microworld for Aphasia" work of Crerer, Ellis, and Dean (1996). An efficacy study involving three patients is reported. All three patients achieved statistically significant improvements in written sentence comprehension as a result of eight hours of treatment focusing on active, passive, and object cleft sentence structures. Treatment effects generalized both to untreated Microworld sentences and to the more naturalistic sentences of the Philadelphia Comprehension Battery (Saffran, Schwartz, Linebarger, Martin, & Bochetto, 1988), with some further evidence of generalization to spoken sentence comprehension. Treatment effects were obtained with minimal input from a clinician.