排序方式: 共有3条查询结果,搜索用时 0 毫秒
1
1.
James D Churchill Pei-Chun Fang Steven E Voss Joyce Besheer Annette L Herron Preston E Garraghty 《Integrative Physiological and Behavioral Science》2003,38(2):91-103
In the present experiments, we investigated the effects of several commonly employed antiepileptic drugs on the performance of adult rats in a Morris water maze task. We found that phenytoin treatment produced the most deleterious performance impairments across all days of training, and that these performance deficits are not likely due to any general sensorimotor impairments. Carbamazepine had milder, but detectable negative effects, as carbamazepine-treated animals exhibited initial acquisition deficits, but rapidly achieved escape levels comparable to controls. In marked contrast, valproate and ethosuximide had no detectable effects on learning in the water maze. These results parallel previous findings in rats treated with these compounds and tested in an instrumental learning task, and are in general agreement with the human clinical literature. To the extent that one might wish to minimize learning deficits associated with maintenance on antiepileptic drugs, phenytoin is definitely not the treatment of choice, while valproate or ethosuximide are apparently much less disruptive. 相似文献
2.
3.
James?D.?Churchill Pei-Chun?Fang Steven?E.?Voss Joyce?Besheer Annette?L.?Herron Preston?E.?GarraghtyEmail author 《Integrative psychological & behavioral science》2003,38(2):91-103
In the present experiments, we investigated the effects of several commonly employed antiepileptic drugs on the performance
of adult rats in a Morris water maze task. We found that phenytoin treatment produced the most deleterious performance impairments
across all days of training, and that these performance deficits are not likely due to any general sensorimotor impairments.
Carbamazepine had milder, but detectable negative effects, as carbamazepine-treated animals exhibited initial acquisition
deficits, but rapidly achieved escape levels comparable to controls. In marked contrast, valproate and ethosuximide had no
detectable effects on learning in the water maze. These results parallel previous findings in rats treated with these compounds
and tested in an instrumental learning task, and are in general agreement with the human clinical literature. To the extent
that one might wish to minimize learning deficits associated with maintenance on antiepileptic drugs, phenytoin is definitely
not the treatment of choice, while valproate or ethosuximide are apparently much less disruptive. 相似文献
1