Is the unilateral lesion of the left substantia nigra pars compacta sufficient to induce working memory impairment in rats?

Adult male Wistar rats with a substantia nigra pars compacta (SNc) lesion induced by intranigral administration of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used as a model of early phase Parkinson's disease (PD). This lesion caused a partial depletion of striatal dopamine (DA). The animals were submitted to a spatial working memory version of the water maze task in which they had to find a hidden (submersed) platform using online-maintained information that the platform remains in the same place during four consecutive trials, but that it is moved to another place every training day. Left, but not right SNc-lesioned rats were impaired in finding the platform in the second trial. This result suggests that the left SNc plays a key role in spatial working memory. Control experiments ruled out the possibility that motor impairment, sensory neglect, and/or impairment in the mental representation of the contralateral spatial environment had affected performance of the SNc-lesioned rats.     

医生献血救人该不该罚——论卫生法律在卫生执法中的正确适用

卫生执法的根本目的是实现卫生法律的立法目的.卫生执法应当尊重卫生法律的基本精神,而不应当对卫生法律断章取义,并应当切实尊重公民的生命健康权.     

Correlation between Changes in Stress-Induced Corticosterone Secretion and GR mRNA Levels

The current study was conducted to determine the potential relationship between stress-induced corticosterone secretion and corticosteroid receptor mRNA levels after 5 days of intermittent stress. In particular, we were interested in the rate at which animals terminate a stress response, and how this termination may be altered by repeated stress. Adult male Sprague-Dawley rats were subjected to either 5 days of restraint stress or 5 days of an unpredictable stress paradigm. Restraint-stress induced corticosterone secretion was measured on Days 1 and 5 in both groups, and animals were killed on Day 6. Glucocorticoid receptor (GR), and mineralocorticoid (MR) mRNA levels were determined using in-situ hybridization techniques. Five days of restraint stress caused an habituation of the plasma corticosterone response to stress measured 60 and 90 min post-stress initiation; this pattern of corticosterone secretion was not observed in the animals subjected to unpredictable stress. Five days of either stress paradigm did not alter MR mRNA levels measured within the hippocampus or GR mRNA levels within the hippocampus or the medial parvocellular division of the paraventricular nucleus of the hypothalamus (mpPVN). However, an individual's GR mRNA levels measured within the CA1/2 region of the hippocampus and the mpPVN were significantly correlated with the degree of habituation of the corticosterone response to stress measured on Day 5. This suggests that an increase in the rate of termination of the stress response and levels of GR within the hippocampus and mpPVN may be functionally related.     

高风险婴儿前瞻性纵向研究与孤独症谱系障碍早期识别

孤独症谱系障碍(Autism Spectrum Disorder, ASD)早期识别有助于早期诊断和早期干预的实施, 对于改善ASD儿童发育结果至关重要。高风险前瞻性纵向研究以高风险婴儿(ASD儿童的年幼同胞, 入组年龄小于12个月)作为主要研究对象, 通过对ASD高风险婴儿(24至36个月之间诊断为ASD的高风险婴儿)的早期发育轨迹的描绘和核心症状早期表现的识别, 为ASD早期识别提供了重要依据。未来可以增加被试数量、延长观察时间并密集观察时间点、关注伴发障碍、综合考虑遗传、环境和文化因素影响, 并结合早期干预研究进行深入探索。未来在中国开展相关研究具有重要的科学价值和临床意义。     

威胁敏感性的概念和测量：生理和认知两种取向

对威胁敏感是人类在应对外部环境过程中不断发展的生存技能。威胁敏感性的研究主要存在两种取向：生理取向以敏感性强化理论为基础, 将行为抑制系统的敏感性界定为威胁敏感性, 量化为个体应对威胁时的生理、情绪和行为反应水平; 认知取向以信息加工的认知风格理论为基础, 将个体在对威胁信息加工过程中的敏感性偏向定义为威胁警觉, 量化为威胁刺激呈现前后的预期水平和探测水平。未来研究还需进一步整合和界定威胁敏感性的概念内涵, 验证各测量指标之间的关系, 拓展不同种类威胁敏感性的研究方法。     

我国教育伦理学研究综述

在我国,教育伦理学在20世纪80年代后期一门独立的学科,在20多年的研究发展中,教育伦理学的研究视域得到了空前的拓展,形成了教育伦理学研究的价值目标体系和伦理规范体系,全面挖掘了教育伦理学的精神内涵,展开了教育伦理学实践机制的研究,呈现出繁荣发展的良好势头。     

"Do as I say, not as I do": family influences on children's safety and risk behaviors

OBJECTIVE: Although there is considerable speculation that family-based socialization processes influence children's safety and risk behaviors, few studies have addressed this important issue. The present study compared the impact of parent practices and teaching about safety on children's current behaviors and their intended future behaviors when they reach adulthood. DESIGN AND MEASURES: Children 7 to 12 years of age were interviewed and asked to report on their parents' practices and teachings (discussions, expectations for children's behavior) regarding five common safety behaviors. As well, the children reported on their own current practices and how they intended to behave when an adult. When appropriate, they provided explanations about why their parents engage in fewer safety behaviors than they required of their children. RESULTS: Children's current behavior was best predicted by parental teaching, however, how children planned to behave when they were adults was best predicted by parents' practices. Children attributed less frequent safety behaviors by their parents than themselves to general attributes of adults and their parent having special skills that made the safety practices less necessary than was true for children. CONCLUSION: These results highlight family influences on children's adoption of safety and risk practices and support the notion of intergenerational transmission of risk behaviors.     

仁者仁医 世之楷模——著名医学家裘法祖院士的行医之道

2004年12月6日,中国科学院院士、著名外科学家、华中科技大学教授、博士生导师、中共党员、同济医学院创始人裘法祖被授予“人民医学家”荣誉称号,这是湖北省人民政府在裘教授迎来九十华诞暨从医65周年之际送给他的一份精美礼物。这位医术精湛、医德高尚、为我国医学事业做出了杰出贡献的著名医学家,受到了人民群众的高度评价和尊重,也为广大的科技工作者,尤其是医学教育和医疗卫生工作者,树立了光辉的榜样。裘教授从医60多年来,不仅以其精湛的医术点燃了无数人的生命之灯而享誉海内外,他的高尚医德同样也赢得了社会的普遍赞誉而成为世之楷模。     

舞动治疗：一种自下而上的精神分裂症干预探索

皮层-基底节-丘脑网络与脑岛网络属于感觉运动相关网络, 这两个网络的改变可能是导致精神分裂症的重要原因。目前主流研究与临床干预聚焦于患者的高级脑区异常, 对感觉运动系统的关注不足。对健康个体的研究发现舞蹈训练对感觉运动相关脑网络具有显著提升作用, 并自下而上地促进高级功能。以上研究提示舞蹈训练可能是干预精神分裂症、改善患者认知功能的新途径。本研究拟借助多模态磁共振成像技术, 以精神分裂症感觉运动相关网络为着力点, 通过分析精神分裂症患者在舞蹈训练前后的脑影像、临床症状及认知行为的改变, 揭示舞蹈训练临床干预的神经机制。     

从诺贝尔生理与医学奖提名看亚洲的医学地位

诺贝尔生理与医学奖是生命科学领域声誉最高的一个奖项,获得者的多少常被作为衡量一个国家科技实力的一项指标.至今,亚洲的科学家仅有1人获得了该项荣誉,但是已经有多名科学家获得了提名,通过描述从1901年到1951年之间诺贝尔生理与医学奖的提名情况来评价亚洲的医学地位.