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一种对动物学习记忆能力突变筛查的新途   总被引:1,自引:0,他引:1  
本文详细描述了一种全自动化的行为检测方案。在自然饲养环境/检测环境(24/7)中, 我们测量了小鼠针对两个给食器中获得食物的比例与它们在相应给食器停留时长的比例进行匹配的精确性与准确性。该方案是对传统条件性习得 (trials-to-acquisition) 行为测验设备的改进, 可以检测动物时间间隔能力的精确性与准确性, 对定时目标选择的相关概率的效果, 以及记忆一天中从不同给食器中获得食物次数的精确性与准确性。该压缩系统避免了在整个实验过程中对小鼠的持握操作, 可忽略实验者/技术员的实验操作时间, 而且可以递送小鼠置入实验环境后, 7~9个实验日中全部3组实验流程产生的大量结果。其中, 第一个实验流程为单个24小时周期内完成的时间匹配能力的筛查, 它对动物的时间、空间估计能力的记忆机制进行精确检测。因此, 该系统允许在有限的实验空间、较短的实验周期内, 对大量的实验小鼠进行有可能存在的学习记忆能力缺陷进行大规模筛查。此外, 该系统运行所依赖的软件可以在公共开放平台获得。  相似文献   
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The present study was designed to examine mothers' emotional reactions, causal attributions, and socialization strategies in response to preschool children's engagement in proactive and reactive physical aggression with peers during free play at school. Participants were 84 mothers (Mage = 31.83, SD = 4.48) with preschool‐aged children (Mage = 4.92, SD = 0. 97), residing in Ankara, Turkey. Supporting our expectations, mothers reacted with negative emotions to both functions of aggressive behaviours, with less anxiety, disappointment, embarrassment, and guilt for reactive aggression. They also believed that reactive aggression is more contextually dependent and intentional and reported more indirect (e.g., asking the child, teacher, or other children to find out more about the situation and aggressive episode) and other‐oriented strategies (e.g., telling the other child to behave properly) to address these behaviours. Overall, our findings suggest that Turkish mothers' feelings, perceptions, and socialization approaches to childhood aggression vary depending on the functions of aggression, and mothers perceive preschool‐aged children's engagement in reactive aggression in the school setting as relatively more acceptable than proactive aggression. Copyright © 2016 John Wiley & Sons, Ltd.  相似文献   
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Journal of Religion and Health - This study was conducted in order to determine factors that influence self-transcendence and meaning in life in the elderly receiving institutional care. This...  相似文献   
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Experimentally naive mice matched the proportions of their temporal investments (visit durations) in two feeding hoppers to the proportions of the food income (pellets per unit session time) derived from them in three experiments that varied the coupling between the behavioral investment and food income, from no coupling to strict coupling. Matching was observed from the outset; it did not improve with training. When the numbers of pellets received were proportional to time invested, investment was unstable, swinging abruptly from sustained, almost complete investment in one hopper, to sustained, almost complete investment in the other-in the absence of appropriate local fluctuations in returns (pellets obtained per time invested). The abruptness of the swings strongly constrains possible models. We suggest that matching reflects an innate (unconditioned) program that matches the ratio of expected visit durations to the ratio between the current estimates of expected incomes. A model that processes the income stream looking for changes in the income and generates discontinuous income estimates when a change is detected is shown to account for salient features of the data.  相似文献   
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According to the Turkish government reports, 2,764,500 registered Syrian refugees are living in Turkey either in refugee camps or freely. In this work, we investigated the cancer incidence among Syrian refugees settled in Turkey between the years of 2012–2015. We carried out a retrospective study of 38,243 refugees with cancer by obtaining data from Ministry of Health, Institution of Public Hospitals in Turkey from 2012 to 2015. The data includes age, type of cancer, years, and region. A statistical analysis was performed on the data collected using the SPSS 20.0 software and the results were formulated. Data were analyzed also by age and years. The mean age of the Syrian refugees was 42.63?±?20.74. When we analyzed the data, the most common types were breast (28.21%), lymphoid leukemia (8.11%), colon (6.57%), Hodgkin’s lymphoma (4.87%), brain (3.51%), myeloid leukemia (3.23%), and non-Hodgkin’s lymphoma (2.80%) among all refugees respectively. Our data showed that cancer types among Syrian refugees are generally similar with the Turkish and world cancer records.  相似文献   
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本文详细描述了一种全自动化的行为检测方案.在自然饲养环境/检测环境(24/7)中,我们测量了小鼠针对两个给食器中获得食物的比例与它们在相应给食器停留时长的比例进行匹配的精确性与准确性.该方案是对传统条件性习得(trials-to-acquisition)行为测验设备的改进,可以检测动物时间间隔能力的精确性与准确性,对定时目标选择的相关概率的效果,以及记忆一天中从不同给食器中获得食物次数的精确性与准确性.该压缩系统避免了在整个实验过程中对小鼠的持握操作,可忽略实验者/技术员的实验操作时间,而且可以递送小鼠置入实验环境后,7~9个实验日中全部3组实验流程产生的大量结果.其中,第一个实验流程为单个24小时周期内完成的时间匹配能力的筛查,它对动物的时间、空间估计能力的记忆机制进行精确检测.因此,该系统允许在有限的实验空间、较短的实验周期内,对大量的实验小鼠进行有可能存在的学习记忆能力缺陷进行大规模筛查.此外,该系统运行所依赖的软件可以在公共开放平台获得.  相似文献   
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Meck and Church (1983) estimated a 5:1 scale factor relating the mental magnitudes representing number to the mental magnitudes representing duration. We repeated their experiment with human subjects. We obtained transfer regardless of the objective scaling between the ranges; a 5:1 scaling for number versus duration (measured in seconds) was not necessary. We obtained transfer even when the proportions between the endpoints of the number range were different. We conclude that, at least in human subjects, transfer from a discrimination based on continuous quantity (duration) to a discrimination based on discrete quantity (number) is mediated by the cross-domain comparability of withindomain proportions. The results of our second and third experiments also suggest that the subjects compare a probe with a criterion determined by the range of stimuli tested rather than by trial-specific referents, in accordance with the pseudologistic model of Killeen, Fetterman, and Bizo (1997).  相似文献   
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On the basis of experimental data, long-range time representation has been proposed to follow a highly compressed power function, which has been hypothesized to explain the time inconsistency found in financial discount rate preferences. The aim of this study was to evaluate how well linear and power function models explain empirical data from individual participants tested in different procedural settings. The line paradigm was used in five different procedural variations with 35 adult participants. Data aggregated over the participants showed that fitted linear functions explained more than 98% of the variance in all procedures. A linear regression fit also outperformed a power model fit for the aggregated data. An individual-participant-based analysis showed better fits of a linear model to the data of 14 participants; better fits of a power function with an exponent β?>?1 to the data of 12 participants; and better fits of a power function with β?<?1 to the data of the remaining nine participants. Of the 35 volunteers, the null hypothesis β?=?1 was rejected for 20. The dispersion of the individual β values was approximated well by a normal distribution. These results suggest that, on average, humans perceive long-range time intervals not in a highly compressed, biased manner, but rather in a linear pattern. However, individuals differ considerably in their subjective time scales. This contribution sheds new light on the average and individual psychophysical functions of long-range time representation, and suggests that any attribution of deviation from exponential discount rates in intertemporal choice to the compressed nature of subjective time must entail the characterization of subjective time on an individual-participant basis.  相似文献   
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