Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Mental fatigue influence on effort-related cardiovascular response: difficulty effects and extension across cognitive performance domains

Two experiments investigated cardiovascular effects of mental fatigue as a function of (1) the difficulty of the cognitive challenge with which participants were confronted, and (2) the relevance of that challenge to the activity that instigated the fatigue. In the first, participants performed an easy (fatigue low) or difficult (fatigue high) counting task and then were presented an arithmetic challenge (task B relevance high) or a scanning challenge (task B relevance low) with instructions that they would avoid a noise if they attained a modest performance standard. Analysis of blood pressure responses assessed during the work periods revealed fatigue main effects, reflecting stronger responses for High Fatigue participants, regardless of the character of the second task. In the second, the procedure was the same except that it included a high performance standard and provided the chance to win a prize. Analysis of the pressure data revealed fatigue x work period interactions, reflecting relatively stronger responses among High Fatigue participants in work period 1, but relatively weaker responses among these participants in work period 2. Results confirm previous findings and support an analysis of fatigue influence on effort and associated cardiovascular responses. They also argue against the idea that mental fatigue influence may be confined to relevant cognitive performance realms.

With Ferenczi,The Contemporary Psychoanalyst is <Emphasis Type="Italic">Other</Emphasis>

Ferenczi's main interests centered on the clinical situation, and through them he felt the need to reformulate, discard and expand many aspects of existing theory to the extent that, in my opinion, he succeeded in constructing a specifically Ferenczian metapsychological conception. After briefly outlining the essentials of Ferenczi's theoretical concepts-highlighting above all the importance given to the interaction with others in psychic configuration and functioning-I go the opposite way, in a "mutatis mutandis" game, "deducing", as though they did not already exist and had to be invented, the technical and clinical approaches implied by this said metapsychology once it is constructed. One conclusion is that a psychoanalysis in tune with Ferenczi's conceptions is different from the one that ruled in the last century and in which a preferably solipsistic reading of Freud was dominant. Moreover, due to reasons that I will attempt to explain, today's psychoanalyst must stop thinking of himself as an absence (this is how I see the so-called "cure type" and others similar to it), and operate as a true other in a vivid relation with the patient.     

Trauma and healing: from ‘furor sanandi’ to ‘animus sanandi’

In his last period (1928–33), Ferenczi tried to complement the ‘negative’ technical principles first introduced by Freud in the 1910s. He introduced diverse and successive ‘positive instructions’, and specific techniques known as ‘elastic’ of ‘relaxation and neocatharsis’, and also made an unsucessful attempt to introduce ‘mutual analysis’. These techniques are implemented around a series of new technical principles including ‘tact’, ‘empathy’, ‘indulgence’, ‘intense sympathy’. All of these positive technical principles and innovations demonstrate the importance of considering the dimension of ‘healing’ in all analytic experiences and the importance of the analyst's functioning as the ‘healer’. The emphasis on the use of these new technical principles is consistent with the emphasis Ferenczi places upon countertransference and traumatic factors in psychopathogenesis.     

Empirical support for the gender‐as‐culture hypothesis.

This investigation provided a test of the gender‐as‐culture, or ‘two cultures’, hypothesis proposed by Maltz and Borker (1982) to explain male/female differences in language use. Analysis of previous empirical investigations located 16 language features that had consistently been shown to indicate communicator gender and these were tested within the framework of the four dimensions of intercultural style proposed by Gudykunst and Ting‐Toomey (1998): direct versus indirect, succinct versus elaborate, personal versus contextual and instrumental versus affective. Study 1 provided preliminary evidence supporting the hypothesized language‐feature‐by‐dimension relationships (e.g., male directives were rated more direct and female uncertainty verbs more indirect). In Study 2, respondents rated multiple exemplars of the 16 language features, as well as 16 contrasting foil sentences, on all four dimensions, finding that nearly all of the variables fell on the hypothesized intercultural dimensions. In Study 3, respondents rated four sets of naturally occurring target sentences and matching foil sentences, representing all language variables, on their appropriate intercultural dimensions in order to establish dimensional polarity. Results across the three studies supported the hypothesized language feature‐by‐stylistic dimension relationship for 15 of the 16 variables: The 6 male language features were rated as more direct, succinct, personal, and instrumental, whereas 9 of the 10 female features were perceived as more indirect, elaborate, and affective. The findings demonstrate that gender preferences for language use function in ways that are consistent with stylistic preferences that distinguish national cultures.     

Anticipatory Processing and Post‐Event Processing in Social Anxiety Disorder: An Update on the Literature

Two repetitive thinking processes that have been proposed in prominent maintenance models of social anxiety disorder (SAD) are anticipatory processing and post‐event processing. Research into these two processes has steadily increased over the last 20 years. This review highlights the main lines of existing research on anticipatory processing and post‐event processing, including studies on the nature of these processes, their association with social anxiety, the predictors, and consequences of these processes, as well as how these processes respond to treatments for SAD. The review also highlights some of the conceptual and methodological issues that have prevented the literature on anticipatory processing and post‐event processing from being more integrated and focused. Finally, the review draws together some new directions in terms of theory and research to further advance the field.     

Vagueness as closeness

This paper presents and defends a definition of vagueness, compares it favourably with alternative definitions, and draws out some consequences of accepting this definition for the project of offering a substantive theory of vagueness. The definition is roughly this: a predicate ‘F’ is vague just in case for any objects a and b, if a and b are very close in respects relevant to the possession of F, then ‘Fa’ and ‘Fb’ are very close in respect of truth. The definition is extended to cover vagueness of many-place predicates, of properties and relations, and of objects. Some of the most important advantages of the definition are that it captures the intuitions which motivate the thought that vague predicates are tolerant, without leading to contradiction, and that it yields a clear understanding of the relationships between higher-order vagueness, sorites susceptibility, blurred boundaries, and borderline cases. The most notable consequence of the definition is that the correct theory of vagueness must countenance degrees of truth.     

On patients’ unique self-knowledge

Abstract

Patients contribute to analytic endeavors through a knowledge of their own unique ways of organizing their experience, of building an intersubjective space with significant others, of the type of life that they consider worth living, and primarily of their specific passions and yearnings. The more that therapists allow the patients’ unique self-knowledge to influence their therapeutic perceptions and decisions, the further they will advance patients’ status as co-experts working together with the therapist to create and formulate new, richer knowledge. In the present article, it is suggested that one of the main reasons why patients’ self-knowledge is excluded from the therapeutic dialogue is that the persuasive power of the therapists’ rich and deep knowledge challenges the patients’ self-authority. Through an illustrative vignette, therapists are recommended to use a metacommunication intervention to restore the balance that has been undermined between the therapist’s authority and the patient’s self-authority.