Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Psychopathy as Predictor and Moderator of Multisystemic Therapy Outcomes among Adolescents Treated for Antisocial Behavior

Objective

The aim of the present study was to determine whether psychopathic traits act as a predictor and/or moderator of the effectiveness of Multisystemic Therapy (MST).

Method

The sample included N?=?256 adolescents (188 boys and 68 girls) referred for conduct problems, randomized to MST or Treatment As Usual (TAU). The mean age was 16 years (SD?=?1.31). Assessments were carried out before and immediately after treatment (6 months later). Three psychopathic traits (callous/unemotional traits, narcissism, and impulsiveness) were assessed with parent reports. Adolescents and parents were informants on externalizing problems.

Results

MST was more effective than TAU in decreasing externalizing problems for the “lower callous/unemotional” and “lower narcissism” group, but not for the “high callous/unemotional” and “high narcissism” group (moderators). Impulsiveness was found to predict more post-treatment externalizing problems rated by adolescents (predictor), but not more post-treatment externalizing problems rated by parents.

Conclusions

These findings point out the clinical relevance of adequately assessing psychopathic traits in adolescents referred for treatment of antisocial behaviour, and identifying those adolescents who show high levels of these traits. It is important to tailor MST specifically to meet the needs of juveniles with high levels of callous/unemotional traits and high levels of narcissism to obtain the same level of effectiveness as with juveniles scoring lower on these traits.     

The ideological manipulation of Hebrew literature in English translation in the 1970s and 1980s

In the past two decades, the field of translation studies has increasingly focused on the role of ideology in literary translation and cross-cultural transfer. This paper presents findings from the close textual comparison of original works of Hebrew literature and their English translations published in the United States during the 1970s and 1980s. I specify translation strategies that have had ideological effects on the source texts, and demonstrate how historically or ethically charged subject matter was manipulated so as to subdue “problematic” aspects of the text for the (largely Jewish) target audience. The two major categories of manipulations had to do with the moral dimension of the portrayal of Israel and Israeli society, particularly in subject matter related to the Israeli–Palestinian conflict; and with the relationship between Israel and other nations, and between Israel and Diaspora Jews. As stressed by recent sociological studies of translation, the translations can be seen both as reflective of contemporary socio-political trends of thought, and as practices playing an unseen role in strengthening these trends.     

Effectiveness of the home‐start parenting support program: Behavioral outcomes for parents and children

This study examined effectiveness of Home‐Start, a program designed to support parents with young children. The aims were (a) to examine whether Home‐Start improved maternal well‐being and (b) to examine whether Home‐Start led to changes in the behavior of mothers or children. Self‐reported and observational data were collected in two waves, using data from 54 mothers and their children between 1.5 and 3.5 years of age who participated in this intervention program for 6 months. These data were compared to 51 comparison families who reported need for parenting support. The results showed a significant improvement in perceived parenting competence, but no effects on maternal depressive moods. Mixed results were found for parenting behavior: Parental consistency and observed sensitivity improved significantly in the Home‐Start group whereas no effects were found on the other parenting variables. Child behavioral problems seemed to diminish at the second measurement in both groups, and therefore these changes cannot be attributed to Home‐Start.     

Toddlers’ Temperament Profiles: Stability and Relations to Negative and Positive Parenting

This study investigated the type and stability of temperament profiles in toddlers, and relations of profile probability to negative and positive parenting trajectories. Mothers (N = 96) rated their child’s (41 girls and 54 boys) Sociability, Anger Proneness, and Activity Level four times during 1 year. The assessment of parenting included both maternal self-reports and observational measures. Latent profile analysis indicated three child temperament profiles: a well-adjusted ‘typical’ profile, an ‘expressive’ profile with heightened externalizing problems, and a ‘fearful’ profile with heightened internalizing problems. Although toddlers’ profile classifications were highly stable across 1 year, individual differences in (changes in) toddlers’ temperament profile probability occurred. We identified negative and positive parenting as environmental mechanisms that were related to the development of temperament profiles over time. These results support the notion that, in addition to having a genetic base, temperament is subject to maturation and experience over time.     

Empirical support for the gender‐as‐culture hypothesis.

This investigation provided a test of the gender‐as‐culture, or ‘two cultures’, hypothesis proposed by Maltz and Borker (1982) to explain male/female differences in language use. Analysis of previous empirical investigations located 16 language features that had consistently been shown to indicate communicator gender and these were tested within the framework of the four dimensions of intercultural style proposed by Gudykunst and Ting‐Toomey (1998): direct versus indirect, succinct versus elaborate, personal versus contextual and instrumental versus affective. Study 1 provided preliminary evidence supporting the hypothesized language‐feature‐by‐dimension relationships (e.g., male directives were rated more direct and female uncertainty verbs more indirect). In Study 2, respondents rated multiple exemplars of the 16 language features, as well as 16 contrasting foil sentences, on all four dimensions, finding that nearly all of the variables fell on the hypothesized intercultural dimensions. In Study 3, respondents rated four sets of naturally occurring target sentences and matching foil sentences, representing all language variables, on their appropriate intercultural dimensions in order to establish dimensional polarity. Results across the three studies supported the hypothesized language feature‐by‐stylistic dimension relationship for 15 of the 16 variables: The 6 male language features were rated as more direct, succinct, personal, and instrumental, whereas 9 of the 10 female features were perceived as more indirect, elaborate, and affective. The findings demonstrate that gender preferences for language use function in ways that are consistent with stylistic preferences that distinguish national cultures.     

Anticipatory Processing and Post‐Event Processing in Social Anxiety Disorder: An Update on the Literature

Two repetitive thinking processes that have been proposed in prominent maintenance models of social anxiety disorder (SAD) are anticipatory processing and post‐event processing. Research into these two processes has steadily increased over the last 20 years. This review highlights the main lines of existing research on anticipatory processing and post‐event processing, including studies on the nature of these processes, their association with social anxiety, the predictors, and consequences of these processes, as well as how these processes respond to treatments for SAD. The review also highlights some of the conceptual and methodological issues that have prevented the literature on anticipatory processing and post‐event processing from being more integrated and focused. Finally, the review draws together some new directions in terms of theory and research to further advance the field.