Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

The temporal stability of some Rorschach features

One hundred nonpatient adults, screened for evidence of personality disorganization, were retested after a three-year interval to study the temporal consistency of the Rorschach. In general, the correlational analysis for 19 basic variables studied, and a directionality analysis for five ratios, illustrate a considerable sturdiness over time. It is postulated that these variables can be separated into situational related indices (state variables), and more stable scores indicative of durable response styles (trait variables), based on the assumption that variables with lower correlations would identify state variables, while the higher correlations would signify the trait features. Nine of the 19 variables yield retest correlations in excess of.     

Der Fall Ludwig Tessnow (1872–1939)

The journeyman carpenter Ludwig Tessnow was sentenced to death for four murders by the Greifswald jury court in 1902. The death sentence was upheld during the retrial in 1906 but was later commuted to life imprisonment. According to the unanimous opinion of psychiatric experts Tessnow committed the crimes while in a state of mental incompetence caused by epileptic twilight states. The court, however, ignored this mitigating circumstance in its decision-making process. Seen from a historical perspective, the case is of forensic psychiatric interest because this criminal trial clearly shows the conflicts in competence which arose in the nineteenth century between judges and medical experts when mental competence had to be assessed. It also allows some insight into how mentally ill offenders were dealt with at the beginning of the twentieth century when the influence of public opinion was (and still is) a noteworthy element of prejudgement which was additionally consolidated by the established system of jury courts. The Tessnow case reveals by way of example the usual practice of official consignment of mentally disordered offenders to hospitals at the end of the nineteenth century until the Nazi era. New particulars of the Tessnow findings adequately verified that Tessnow had not been executed in the Greifswald prison as mistakenly believed. It could be proved that Ludwig Tessnow was admitted to the LandesheilanstaltStralsund (state mental hospital in Stralsund) where he became a victim of the Nazi euthanasia program.     

Sublexical and lexical representations in speech production: effects of phonotactic probability and onset density

Phonotactic probability, neighborhood density, and onset density were manipulated in 4 picture-naming tasks. Experiment 1 showed that pictures of words with high phonotactic probability were named more quickly than pictures of words with low phonotactic probability. This effect was consistent over multiple presentations of the pictures (Experiment 2). Manipulations of phonotactic probability and neighborhood density showed only an influence of phonotactic probability (Experiment 3). In Experiment 4, pictures of words with sparse onsets were named more quickly than pictures of words with dense onsets. The results of these experiments provide additional constraints on the architecture and processes involved in models of speech production, as well as constraints on the connections between the recognition and production systems.