Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Sex and generational differences in desired characteristics in mate selection

This study compared the ranking of 18 personal characteristics or qualities which college students might use in selecting a future mate and builds on six other assessment periods from 1939-1996 which dealt with this issue. Among the most consistent findings for all seven assessment periods is the high value both sexes place on dependable character, emotional stability/maturity, pleasing disposition, and mutual attraction/love. Men across all assessment periods placed a higher value than women on good health, good cook/housekeeper, and good looks, while women placed a higher value on ambitious/industrious, similar educational background, and good financial prospect. These trends could go along with ethological theory. For both sexes chastity and similar religious background gained value; however, this may be an artifact of the current sample of 100 students.     

Eighteen month test-retest stability of the youth self report in a sample of Catalonian adolescents

The aim of this study is to assess the test-retest stability of the Spanish version of Youth Self Report after 18 mo. for a sample of 357 Catalonian high school students (158 boys and 199 girls). At Time 2 the girls' scores increased on Delinquent and Aggressive Behavior scales and, therefore on Externalizing scores. At Time 2 the boys' scores increased on Attention Problems and Delinquent Behavior and decreased on Anxious/Depressed, Social Problems, and Internalizing scales. Significant differences in the remaining scales were not observed. The test-retest intraclass correlations for the broad-band scales ranged between .62 (Internalizing) and .68 (Externalizing) and for the narrow-band scales between .37 and .67. The correlations for girls and boys were similar but slightly higher for girls on Anxious/Depressed and Thought Problems.     

大学二年级学生人际宽恕与报复心理及其与抑郁的关系研究

采用沉思量表、报复动机量表、宽恕倾向量表、宽恕态度量表和流调中心用抑郁量表对236名大二学生进行问卷调查,综合探讨大学生人际宽恕和报复心理及其与抑郁的关系。研究发现:(1)男大学生的报复倾向显著高于女大学生。(2)宽恕倾向与报复倾向及对侵犯的沉思程度显著负相关。沉思程度和抑郁显著正相关。(3)沉思程度和宽恕倾向对抑郁分别具有显著的正向和负向的预测作用。(4)大学生的宽恕倾向和宽恕态度的相互作用以及宽恕倾向和报复倾向之间的交互作用对抑郁均没有显著预测作用。     

Field test of the Cognitive Interview: enhancing the recollection of actual victims and witnesses of crime

The Cognitive Interview was tested in the field to enhance the recollection of actual victims and witnesses of crime. The technique is based on laboratory-tested principles of memory retrieval, knowledge representation, and communication. Seven experienced detectives from the Metro-Dade Police Department were trained to use the technique and were compared with 9 untrained detectives. Before and after training, all detectives tape-recorded interviews with victims and witnesses of crime. The trained detectives elicited 47% more information after than before training, and 63% more information than did the untrained detectives. Overall collaboration rates (94%) were extremely high and were equivalent for pre- and posttrained interviews. Because the Cognitive Interview reliably enhances memory and is easily learned and administered, it should be useful for a variety of investigative interviews.     

Influence of the friends' network in drug use and violent behaviour among young people in the nightlife recreational context

Party networks of young people are important for socialization, but can also influence their involvement in risk behaviours. We explored the individual-centred networks (7.360 friends) of 1.363 recreational nightlife users in 9 European cities in 2006, through 22 friend characteristics. As expected, deviant networks are related to violence, smoking, illegal drug use and drunkenness. However, socializing and helping networks are also associated with fighting, smoking, use of illegal drugs--except for cannabis--and getting drunk. Not having a deviant network and not having a helping/socializing network can be protective against smoking, violence and illegal drug use, as well as protecting ex-users from relapse. Closeness to friends is also a network protective factor. A possible reason why socializing networks are related to fighting, illegal drugs and drunkenness is that these behaviours are somehow desired, adaptive and prosocial in recreational contexts.     

Say-do correspondence to improve disruptive behaviors in adults with Down's syndrome

The most acknowledged strategies for the treatment of disruptive behaviours are those that are based on direct contingency management. Other procedures allow the therapist, or educational agent, not to be present in the context in which the behavioural change has to take place: the say-do correspondence training procedures, which have proven effective across behaviours and populations. Nevertheless, there is surprisingly little evidence of the effectiveness of such procedures with populations presenting developmental disabilities. This study describes the implementation of say-do correspondence training to modify 5 disruptive behaviours present in 5 adult subjects diagnosed with Down's syndrome, showing very positive results. The advantages of using say-do correspondence training procedures in developmental disabilities are discussed.     

Information processing bias against emotional facial expressions in social anxiety

The present study examined whether information processing bias against emotional facial expressions is present among individuals with social anxiety. College students with high (high social anxiety group; n  = 26) and low social anxiety (low social anxiety group; n  = 26) performed three different types of working memory tasks: (a) ordering positive and negative facial expressions according to the intensity of emotion; (b) ordering pictures of faces according to age; and (c) ordering geometric shapes according to size. The high social anxiety group performed significantly more poorly than the low social anxiety group on the facial expression task, but not on the other two tasks with the nonemotional stimuli. These results suggest that high social anxiety interferes with processing of emotionally charged facial expressions.