Sex differences in prenatal epigenetic programming of stress pathways

Maternal stress experience is associated with neurodevelopmental disorders including schizophrenia and autism. Recent studies have examined mechanisms by which changes in the maternal milieu may be transmitted to the developing embryo and potentially translated into programming of the epigenome. Animal models of prenatal stress have identified important sex- and temporal-specific effects on offspring stress responsivity. As dysregulation of stress pathways is a common feature in most neuropsychiatric diseases, molecular and epigenetic analyses at the maternal-embryo interface, especially in the placenta, may provide unique insight into identifying much-needed predictive biomarkers. In addition, as most neurodevelopmental disorders present with a sex bias, examination of sex differences in the inheritance of phenotypic outcomes may pinpoint gene targets and specific windows of vulnerability in neurodevelopment, which have been disrupted. This review discusses the association and possible contributing mechanisms of prenatal stress in programming offspring stress pathway dysregulation and the importance of sex.     

Development of the Mental Health Locus of Control and Mental Health Locus of Origin Scales

The Mental Health Locus of Control (MHLC) Scale is an area-specific measure of locus of control expectancies designed to predict mental health related behaviors, particularly those occurring in treatment situations. The discriminant validity of the MHLC, in contrast with Rotter's 1-E measure of generalized expectancies, was demonstrated with two mental health related variables: beliefs concerning etiology of psychopathology, and information about abnormal psychology. Beliefs about etiology were measured by the Mental Health Locus of Origin (MHLO) Scale. The primary hypothesis, that individuals with 'endogenous' beliefs about etiology tend to have 'external' expectations for the client's role in treatment, was supported by a statistically significant (p < .001) correlation between the MHLC and MHLO Scales.     

Validation of the Measure of Delinquent Social Identity Among Youth Offenders in the UK

ABSTRACT

The current study aimed to develop and validate the Measure of Delinquent Social Identity (MDSI). Dimensionality and construct validity of the MDSI was investigated in a sample of youth offenders (N = 536). Four alternative models of the MDSI were estimated using Mplus. The model identified as being the best fit for the data was a bifactor model with three dimensions (cognitive centrality, in-group affect, in-group ties) while controlling for the general factor. The three subscales differentially correlated with criminal friend index, self-esteem, parental attachment, and peer rejection. Limitations and advantages, including practical implications, of the current research are discussed.     

Identification of partially presented meaningless patterns: effect of completeness and distinctiveness

The role of parts versus that of wholes in a visual perception has been debated for a century as two opposite approaches, namely, an analytic and holistic. In two psychophysical experiments we investigated whether the stimulus completeness or distinctiveness is essential for identification of the partially presented patterns under brief presentation conditions. For this purpose, a special class of stimuli was constructed in such a way that the patterns could be divided into informative and redundant parts. The first experiment clearly demonstrated the importance of the redundant part for effective pattern identification for the majority of subjects. The second experiment revealed the direct dependence of identification accuracy of the patterns on their completeness (2, 3, 4, 5, or 6 elements). Familiarisation of subjects with the test stimuli influenced the strength of this dependence.     

Self-cutting: patient characteristics compared with self-poisoners

A large ( n = 14,892) consecutive sample of deliberate self-harm (attempted suicide) patients who presented to a general hospital in the United Kingdom during a 23-year study period was examined (over two consecutive time periods) in order to compare the characteristics of those who used self-cutting ( n = 428) and those who self-poisoned ( n = 11,065). Patients who used different methods on other occasions, or were not assessed by the psychiatric service, were excluded. In the first time period (January 1976-June 1988), the self-cutters were distinguished from the self-poisoners by more often being male, single, not employed, and having a history of previous deliberate self-harm. In the second time period (July 1988-December 1998) the self-cutters were again distinguished by more often being male and having a history of previous deliberate self-harm, but also by being more likely to live alone, misuse alcohol, and have low suicidal intent scores. The finding of an excess of males among the self-cutters is contrary to the impression in the literature that self-cutting presentations to general hospitals more often involve females. It also indicates that the treatment needs of those who deliberately cut themselves are likely to differ from those of self-poisoners.     

A Survey on Development and Applications of the Multi‐criteria Decision Making Method MULTIMOORA

This paper focuses on the MULTIMOORA method. Specifically, it discusses its development as well as extensions alongside with an overview of their applications. Indeed, the MULTIMOORA is a relatively new multi‐criteria decision making method consisting of the three parts. Therefore, it is specific with peculiarities of both complete and partial aggregation techniques. The MULTIMOORA method consists of the three parts, namely the Ratio System, the Reference Point, and the Full Multiplicative Form. The paper discussed the extensions of MULTIMOORA into the fuzzy environment and group decision making. The carried out survey identified the two major areas of application of MOORA and MULTIMOORA, namely engineering decision support for technological development and economic researches. The economic researches can further be classified into those related to micro‐level or macro‐level analyses. Copyright © 2013 John Wiley & Sons, Ltd.     

Medicolegal stress at work

Connections between work, stress, and emotional distress have become the object of extensive litigation in the workers' compensation system and other legal forums. This article examines some of this activity from the perspective of medicolegal sociology. It explores five forums in which discussion of these connections takes place-every day life, science, within organizations, adjudicatory inquiries, public policy-and the moral stress discourse that helps bind these discussions together. Particular attention is paid to stress litigation stemming from investigations into violations of the law, principdy police work. Workers' compensation stress claims are viewed as part of an extensive societal medicolegal inquiry into the emotional underlife of work organizations.