Selecting a best multiattribute alternative with partial information about attribute weights

Use of approximate weights would greatly simplify decision analysis under certainty since detailed weight elicitation could be avoided. This paper examines the degree to which rank order information about weights can be used to identify a best alternative, or falling uniqueness prescribes an easily implemented rule for selecting a ‘best’ alternative. The prescribed rule uses as weights the centroid of the feasible region defined by the rank order information. In conjunction with the rule, the value of the rank order information can be determined using an ‘expected gain from weight precision’ (EGWP) measure, analogous to ‘expected value of perfect information’ in decision analysis under uncertainty.     

Counseling and screening for cystic fibrosis in patients with congenital bilateral absence of the vas deferens: Patient perceptions

Congenital bilateral absence of the vas deferens (CBAVD) occurs in approximately 1.3% of infertile males and is thought to be, in most cases, a primarily genital form of cystic fibrosis (CF). Fourteen males with CBAVD considering microsurgical sperm aspiration from the epididymis (MESA) and in vitro fertilization were seen for genetic counseling and screening for CF. To retrospectively evaluate these patients' perceptions of the counseling and screening information, we conducted structured telephone interviews to assess their recall of information about CF and its impact on their health concerns and reproductive plans. We found that, as the health implications of CF are abstract and not as important to patients as the diagnosis of CBAVD itself, patients tend to view their CF status primarily in terms of their reproductive potential. Retrospective analysis afforded us an opportunity to identify the psychosocial issues of most concern to this unique patient population.     

Oculomotor programming disturbances in the dementia syndrome

Three types of oculomotor programming disturbances are described in patients with the dementia syndrome. This report describes two of these abnormalities, poorly regulated gaze patterns and a programming type of gaze perseveration. All patients showed poorly regulated gaze patterns in contrast to the normal controls, whereas on the whole only the moderately affected patients showed the programming type of gaze perseveration. The third type of oculomotor programming disturbance is efferent perseveration of gaze (a hypokinetic, "staring" type of gaze pattern) and can be seen with severe dementia. The possible significance of these findings is discussed.     

Axiomatic and numerical conjoint measurement: An evaluation of diagnostic efficacy

Synthetic data are used to examine how well axiomatic and numerical conjoint measurement methods, individually and comparatively, recover simple polynomial generators in three dimensions. The study illustrates extensions of numerical conjoint measurement (NCM) to identify and model distributive and dual-distributive, in addition to the usual additive, data structures. It was found that while minimum STRESS was the criterion of fit, another statistic, predictive capability, provided a better diagnosis of the known generating model. That NCM methods were able to better identify generating models conflicts with Krantz and Tversky's assertion that, in general, the direct axiom tests provide a more powerful diagnostic test between alternative composition rules than does evaluation of numerical correspondence. For all methods, dual-distributive models are most difficult to recover, while consistent with past studies, the additive model is the most robust of the fitted models.Douglas Emery is now at the Krannert Graduate School of Management, Purdue University, West Lafayette, IN, on leave from the University of Calgary.     

A head-mounted scene holder for eye movement research

An inexpensive head-mounted scene holder is described. In contrast to the usual biteboard/fixed-head approach, the present apparatus allows head movements without introducing substantial artifact. This enables eye movement investigations of brain-damaged or psychiatric subjects who often cannot maintain prolonged head immobility; also, the unit makes possible subjects’ verbal reports coincident with visual scanning.     

Clinical Utility of Chromosomal Microarray Analysis of DNA from Buccal Cells: Detection of Mosaicism in Three Patients

Mosaic chromosomal abnormalities are relatively common. However, mosaicism may be missed due to multiple factors including failure to recognize clinical indications and order appropriate testing, technical limitations of diagnostic assays, or sampling tissue (s) in which mosaicism is either not present, or present at very low levels. Blood leukocytes have long been the “gold standard” sample for cytogenetic analysis; however, the culturing process for routine chromosome analysis can complicate detection of mosaicism since the normal cell line may have a growth advantage in culture, or may not be present in the cells that produce metaphases (the lymphocytes). Buccal cells are becoming increasingly utilized for clinical analyses and are proving to have many advantages. Buccal swabs allow for simple and noninvasive DNA collection. When coupled with a chromosomal microarray that contains single nucleotide polymorphic probes, analysis of buccal cells can maximize a clinician’s opportunity to detect cytogenetic mosaicism. We present three cases of improved diagnosis of mosaic aberrations using buccal specimens for chromosomal microarray analysis. In each case, the aberration was either undetectable in blood or present at such a low level it likely could have gone undetected. These cases highlight the limitations of certain laboratory methodologies for identifying mosaicism. We also present practice implications for genetic counselors, including clinic workflow changes and counseling approaches based on increasing use of buccal samples.     

Negative Life Events and Posttraumatic Stress Disorder among Incarcerated Boys with Callous-Unemotional Traits

Historically, researchers have searched extensively for biological explanations regarding causes of psychopathy and its theorized developmental precursor, callous-unemotional (CU) traits (i.e., lack of empathy/guilt, shallow affect). In consequence, environmental factors such as exposure to negative life events and posttraumatic stress that often follows have been relatively overlooked. The present study tests whether exposure to negative life events and related symptoms of posttraumatic stress disorder (PTSD) are associated with CU traits among a sample of 238 incarcerated boys. Additionally, youth high on CU traits were disaggregated into primary and secondary variants based on the presence of anxiety to examine differences in their experiences of negative life events and PTSD symptoms. Results suggest that CU traits are significantly positively associated with both the experience of negative life events as well as PTSD symptomatology. Additionally, high-anxious youth scoring high on CU traits (secondary variant) were significantly more likely to report a history of negative life events and PTSD symptoms than were lower anxious boys scoring high on CU traits (primary type) and non-psychopathic youth. Thus, study findings warrant further exploration of how trauma might impact or maintain the development of CU traits over time and indicate that issues of differential diagnosis must be considered in order to more effectively tailor treatment for trauma-exposed CU youth.