成体干细胞可塑性研究中的若干哲学思考

随着干细胞生物学研究的不断深入,成体干细胞被发现可以分化成组织来源与其无关的其他系统的细胞,即成体干细胞的可塑性.但是最近不断有学者对其提出质疑,认为可塑性可能是与"细胞融合"或成年组织中的"多潜能成年祖细胞"有关.面对可塑性上两种截然相反的观点,我们在热切关注其研究进展的同时,也引发了一连串的哲学思考.     

Prima facie and seeming duties

Sir David Ross introduced prima facie duties, or acts with a tendency to be duties proper. He also spoke of general prima facie principles, wwhich attribute to acts having some feature the tendency to be a duty proper. Like Utilitarians from Mill to Hare, he saw a role for such principles in the epistemology of duty: in the process by means of which, in any given situation, a moral code can help us to find out what we ought to do.After formalizing general prima facie principles as universally quantified conditionals I will show how seeming duties can be detached from them. There will be examples involving lies, burnt offerings and the question of whether to have a napkin on your lap while eating asparagus. They will illustrate the defeasibility of this detachment, how it can lead into dilemmas, and how general prima facie principles are overridden by more specific ones.I've been lucky to discuss parts of this project with among others Jeff Horty, Paul McNamara, Alasdair MacIntyre, Wlodek Rabinowicz and Michael Slote. Thanks, too, to Henry Prakken and the reviewers for Studia Logica     

The given of achievement and the reluctance to assent: Argument and inquiry in the post-postmodern world

Changes in the social, political, and intellectual climate worldwide portend radical changes in how humans view themselves and their world. This essay argues that the twenty-first century will usher in apost-postmodern age. The new epoch will be one in which argument practices more closely resemble their modernist forbears. The given of achievement will overcome the postmodern reluctance to assent. Argument will be practiced against the backdrop of realist philosophical frameworks and will be viewed as contributing to the accretion of knowledge.An earlier version of this paper was presented at the Speech Communication Association Annual Conference, Atlanta, Georgia, November 1991.To assert that moral, aesthetic, and factual arguments are statistically derived, is not to argue that there is no such thing as absolute goodness, beauty, or truth. It is to declare that these ultimate values have little relevance in practical argument.- Daniel McDonald     

Ecofeminism: What One Needs to Know

Ecofeminism refers to feminist theory and activism informed by ecology. Ecofeminism is concerned with connections between the domination of women and the domination of nature. Although ecofeminism is a diverse movement, ecofeminist theorists share the presuppositions that social transformation is necessary for ecological survival, that intellectual transformation of dominant modes of thought must accompany social transformation, that nature teaches nondualistic and nonhierarchial systems of relation that are models for social transformation of values, and that human and cultural diversity are values in social transformation. Ecofeminist theology, ethics, and religious perspectives are particularly concerned with the integration of science and religion. Examples of religious or spiritual ecofeminisms are North American Christian ecofeminism, North American womanist Christian theology, neopagan Wiccan ecofeminism, Native American ecofeminism, and Third World ecofeminism.     

An Unfinished Debate: What Are the Aims of Religion and Science?

I discuss the kinds of fundamental questions that must be addressed by people who develop theories about how religion and science are (or should be) related. After categorizing these questions as axiological, epistemological, ontological, or semantic, I focus on those that concern the goals of religion and science (the axiological issues). By distinguishing between epistemic and practical goals, individual and collective goals, and manifest and latent goals, I identify seven axiological questions. The various answers that religion/science theorists give or presuppose to these axiological questions help to explain why such deep, ongoing differences continue among them.     

Argumentation and Interpersonal Justification

There are distinct but legitimate notions of both personal justification and interpersonal justification. Interpersonal justification is definable in terms of personal justification. A connection is established between good argumentation and interpersonal justification.     

PREVENTING ABORTION AS A TEST CASE FOR THE JUSTIFIABILITY OF VIOLENCE

This paper explores the rationale for violence and coercion aimed at preventing abortion conceived as the killing of an innocent person. Some important arguments for personhood at conception are examined, and in the light of the examination the paper considers whether they warrant concluding that a free and democratic society should pass laws recognizing personhood at conception. The wider concern is what principles such a society should use as a basis for legal coercion and what principles conscientious individuals should use insofar as they judge that self-defense or, especially, protection of the innocent, requires violence.     

Hoisted by their own petards: Philosophical positions that self-destruct

Philosophers have not resisted temptation to transgress against the logic of their own conceptual structures. Self-undermining position-taking is an occupational hazard. Philosophy stands in need of conceptual therapy.The author describes three conceptions of philosophy: the narcissistic, disputatious, and therapeutic. (i) Narcissistic philosophy is hermetic, believing itself to contain all evidence that can possibly be relevant to it. Philosophy undertaken in this spirit has led to defensive, monadically isolated positions. (ii) Disputatious philosophies are fundamentally question-begging, animated by assumptions that philosophical adversaries reject. (iii) The intention of therapeutic philosophy is to study philosophical positions from the standpoint of their internal consistency, or lack of it. In particular, its interest is in positions that either compel assent, because they cannot be rejected without self-referential inconsistency, or self-destruct because self-referential inconsistency cannot be avoided. The article's focus is on the latter. Several examples of self-undermining positions are drawn from the history of philosophy, exemplifying two main varieties of self-referential inconsistency: pragmatical and projective.     

Did Jesus Discover Forgiveness?

This essay explores Hannah Arendt's claim that Jesus was the “discoverer” of forgiveness. It assesses Charles Griswold's view that person‐to‐person forgiveness is in evidence in Greek culture and practice before Jesus. The essay refines Griswold's view and suggests that person‐to‐person forgiveness is a cultural universal. The essay makes observations about the significance of the different words that denote person‐to‐person forgiveness; it also explores the implications of reading the New Testament writings on person‐to‐person forgiveness in the chronological order in which they were written. From a close reading of the early New Testament documents, the essay makes two suggestions about the Western tradition of forgiveness. First, it suggests that Paul the apostle is the first to identify person‐to‐person forgiveness as a moral virtue. Second, it suggests that in the Synoptic tradition, Jesus is the first to identify person‐to‐person forgiveness as a discrete category of behavior distinct, for example, from pardoning, excusing, waiving, or ignoring the wrongs of others.