Exercise type relates to inhibitory and error processing functions in older adults

ABSTRACT

This study investigated the association between exercise type and inhibition of prepotent responses and error detection. Totally, 75 adults (M = 68.88 years) were classified into one of three exercise groups: those who were regular participants in open- or closed-skill forms of exercise, and those who exercised only irregularly. The participants completed a Stroop and task-switching tasks with event-related brain potentials (ERPs) recorded. The results revealed that regular exercisers displayed faster reaction times (RTs) in the Stroop task compared with irregular exercisers. The open-skill exercisers exhibited smaller N200 and larger P300a amplitudes in the Stroop task compared with irregular exercisers. Furthermore, the open-skill exercisers showed a tendency of shorter error-related negativity latencies at the task-witching test. The findings suggest that older adults may gain extra cognitive benefits in areas such as inhibition functioning and error processing from participating in open-skill forms of physical exercises.     

错误相关负波（ERN）在精神病理学研究中的应用

错误相关负波（error-related negativity, ERN）是由行为错误诱发的一种脑电波成分,最大峰值在错误反应之后的50ms左右,偶极子源定位于前扣带回（anterior cingulate cortex, ACC）附近。错误加工（error processing）的经典研究范式中出现的ERN成分可能反映了ACC具有错误检测、冲突监控、强化学习、情绪动机等功能。大量研究表明过度的和不足的错误相关脑活动（hyperactive and hypoactive error processing）可能分别与精神病理学的内化性和外化性障碍（internalizing and externalizing disorders）相关联。内化性和外化性障碍的内表型（endophenotype）的研究,还存在许多值得进一步探索的问题。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子（vascular endothelial growth factor,VEGF）是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一。结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出。本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述。     

小鼠新颖寻求特质对酒精的运动激活效应的影响

新颖寻求(或感觉寻求)特质与许多成瘾药物的易感性密切相关。例如, 高、低新颖寻求动物对可卡因、苯丙胺和吗啡等成瘾药物的奖赏、运动激活、强化效应的反应存在差异。长期饮用酒精也容易成瘾, 但尚未发现关于新颖寻求特质影响酒精成瘾的报道。本实验采用药物成瘾研究中常用的自发活动模型, 考察了高、低新颖寻求动物在酒精急性处理、慢性处理和激发过程中的行为表现。实验过程中首先采用两种新颖寻求模型, 即新颖环境中自发活动模型和新颖客体偏爱模型, 将昆明小鼠分别区分为高、低自发活动组和高、低新颖客体偏爱组, 连续10天给予酒精(2g/kg/d, i.p.)或等量盐水处理, 戒断2天后所有小鼠接受酒精(2g/kg)激发。实验结果表明, 新颖环境低自发活动小鼠比新颖环境高自发活动小鼠对酒精急性、慢性处理导致的运动激活效应更敏感; 在酒精激发期前者的自发活动水平也高于后者。本实验结果说明新颖环境中自发活动特质影响动物对酒精导致的运动激活效应的反应。     

复发转移性乳腺癌患者血浆VEGF水平的临床价值研究

探讨血浆血管内皮生长因子（P-VEGF）在乳腺癌术后复发转移患者中的表达情况及临床意义。采用酶联免疫吸附试验检测50例术后复发转移性乳腺癌患者及20例乳腺良性疾病对照组的P-VEGF含量,同期采用微粒子化学发光法检测术后复发转移性乳腺癌患者血清CEA和CA15-3的表达情况,进行对比研究。结论认为转移肿瘤细胞可产生大量...     

Longitudinal Modeling of Adolescents' Activity Involvement, Problem Peer Associations, and Youth Smoking

Longitudinal associations among different types of organized activity involvement, problem peer associations, and cigarette smoking were examined in a sample of 1040 adolescents (mean age = 15.62 at baseline, 16.89 at 15-month assessment, 17.59 at 24 months) enriched for smoking experimentation (83% had tried smoking). A structural equation model tested longitudinal paths between three categories of involvement (team sports, school clubs and activities, and religious activities, measured at baseline and 15 months), problem peer associations (baseline and 15 months), and cigarette smoking behavior (baseline and 24 months). Multi-group analyses indicated pathways differed by type of activity and adolescent gender. Boys' baseline team sports and religious involvement predicted lower levels of smoking at 24 months via continued activity involvement at 15 months. Girls' involvement in school clubs and activities and religious activities indirectly predicted lower levels of smoking at 24 months via reduced exposure to problem peers at 15 months.     

Health and Aging: A Perspective from the Far East

Singapore is an urban, highly industrialized country in South East Asia. By 2030, one-fifth of the population is projected to be composed of citizens aged above 65 years. Research on aging has largely focused on the effects of deteriorating physical ability on daily functioning capabilities (Iwarsson & Isacsson, 1997; Warr, 1995). More recently, the role of self-perceived usefulness, competence and control on well-being in the elderly have been investigated (Heberlein, Licht & Licht, 1999; Ranzjin, Keeves, Luszcz, & Feather, 1998). In other fields, activity and involvement have been identified as effective coping devices (Nair, 1989; Shalit, 1988). The present study compared the conceptual understanding of the esteem and well-being of the elderly on the dimensions of activity, involvement, and control, as viewed by an undergraduate sample (n = 60) and a cross-section of seniors (n = 71). Three separate factor analyses reflected interesting variations in the conceptual frameworks.     

父母婚姻质量与儿童内化问题:父母情绪表达的中介作用与儿童迷走神经活动的调节作用

基于家庭系统理论与个体-环境交互理论,研究考察了父母情绪表达在父母婚姻质量与儿童内化问题关系中的中介作用,以及儿童迷走神经活动的调节作用。研究选取155名6~7岁小学儿童为被试,运用便携式生理多道记录仪采集儿童静息与任务状态下的心电（ECG）与呼吸率,换算出基线RSA与RSA反应作为迷走神经活动的指标,采用母亲报告的《婚姻质量问卷》、《家庭情绪表达问卷》和《儿童行为量表》测评父母婚姻质量、父母情绪表达及儿童内化问题。结果发现：（1）父母婚姻质量负向预测小学儿童内化问题;（2）父母消极、积极情绪表达在父母婚姻质量与小学儿童内化问题关系中起中介作用;（3）小学儿童迷走神经张力（基线RSA）调节父母消极情绪表达与儿童内化问题关系。研究结果表明父母婚姻质量不仅直接影响儿童内化问题,同时会通过父母情绪表达间接地影响儿童内化问题。另外,较高迷走神经张力能够缓冲父母消极情绪表达对儿童内化问题的影响。     

Psychological mechanisms underlying the relationship between commercial physical activity app use and physical activity engagement

PurposePrevious studies have indicated a relationship between the use of commercial physical activity apps (e.g., Fitbit, Strava) and physical activity engagement. The use of social components of such apps, in particular app-specific communities (connecting with other app users) and existing social networking platforms (e.g., Facebook) have the potential to enhance physical activity. This study aimed to explore the psychological mechanisms underlying the relationship between the use of commercial physical activity apps (and their social components) and physical activity engagement.MethodAn online cross-sectional survey assessed physical activity, use of commercial physical activity apps (and their associated social components), and psychological constructs (social support, self-efficacy, motivation, trait competitiveness, trait social comparison).Results1274 adults aged 18–83 years (M_age = 34.1 ± 13.5 years, 87.6% female) participated. App use was positively associated with physical activity engagement. The relationship between app use and physical activity was fully mediated by social support, self-efficacy, intrinsic motivation and identified regulation. Trait competitiveness, but not trait social comparison, moderated the relationship between app use and physical activity. Most features (e.g., sharing posts, providing or receiving encouragement) of the social components of apps were positively associated with psychological constructs linked to engagement in physical activity. Mediation pathways linking features of existing social networking platforms with physical activity were found. Specifically, sharing posts was linked to higher engagement in physical activity via positive associations with self-efficacy, and receiving encouragement with linked to higher engagement in physical activity via positive associations with both self-efficacy and identified regulation. In addition, engagement in comparisons was associated with lower self-efficacy and higher external regulation, and in turn, lower physical activity.ConclusionsThe relationship between the use of commercial physical activity apps and physical activity is underpinned by social support, self-efficacy and autonomous motivations. The findings highlight the importance of trait competitiveness, which should be taken into consideration when leveraging physical activity apps. Overall, the present study demonstrated that commercial physical activity apps (and their social components) hold great potential to increase physical activity engagement given their associations with psychological constructs strongly linked with physical activity.