Making Cells Worthwhile: Calculations of Value in a European Consortium for Induced Pluripotent Stem Cell Banking

The StemBANCC consortium was a large European consortium bringing together scientists from academic institutions and the pharmaceutical industry. The aim of the consortium was to produce 1500 induced pluripotent stem cell (iPSC) lines from participants with a variety of common, complex diseases. These cell lines were intended to help develop iPSC as tools for screening small molecule drug candidates and modelling human diseases in vitro. The scale of investment in this and other biobanks presents iPSC as a valuable commodity. However, StemBANCC was also mandated to make its making cells and data available to European researchers on a not-for-profit basis. To understand how making this quantity of stem cells and data available is configured as a valuable and worthwhile investment for the consortium partners, research materials (project documents, scientific literature and interviews with scientists working on StemBANCC) were analysed using theoretical tools from Valuation Studies. Combining STS and economic sociology, valuation studies analyse how the worth of things, ideas and phenomena result from context-specific practices of assessment and evaluation; worth incorporates moral, financial, scientific, economic. social and cultural registers of value. In this sense, practitioners evaluate the worth of the StemBANCC cells and data at a variety of sites, from participant recruitment to online databases. This provides an alternative to biovalue and similar conceptual models for theorising the generation of value in the Life Sciences.     

When Does Construction Enhance Product Value? Investigating the Combined Effects of Object Assembly and Ownership on Valuation

Recent findings have shown that even without the ability to customize a product, individuals pay more for goods that they assembled. In this paper we examine which components of this creation process account for the increase in valuation, and whether it operates equally for owners and non‐owners of the self‐assembled object. Based on the self‐extension theory of ownership, we propose a psychological mechanism by which the assembly process strengthens the self–object association. In three experiments, we find that—although witnessing the assembly process or assembling a similar product can increase participants' evaluation of, and attachment to, a product that they own—a greater and more consistent increase in valuation and attachment arises when owners assemble their product themselves. Seemingly, merely learning about the assembly process plays only a small role in enhancing value; for substantial increases in value, one must actually assemble the product oneself. Contrary to the previous findings on the effects of labour on willingness to pay, we find little effect of product assembly among non‐owners of the product. We suggest that self‐assembly encourages objects to be incorporated into the self, but that this occurs most effectively when one owns the product. Copyright © 2015 John Wiley & Sons, Ltd.     

DEVELOPMENT OF THE PARENT‐CHILD PLAY SCALE FOR USE IN CHILDREN WITH FEEDING DISORDERS

The Parent‐Child Play Scale was developed as a scale that complements the Parent‐Child Feeding Scale, created by I. Chatoor et al. (1997), to evaluate mother–infant/toddler interactions in two different caregiving contexts of a young child's everyday life, specifically play and feeding. This Play Scale can be used with infants and toddlers ranging in age from 1 month to 3 years and provides reliable global ratings of mother–child interactions during 10 min of videotaped free‐play in a laboratory setting. The scale consists of 32 mother and infant/toddler interactive behaviors which are rated by trained observers from videotaped observations. Four subscales are derived: Dyadic Reciprocity, Maternal Unresponsiveness to Infant's/Toddler's Cues, Dyadic Conflict, and Maternal Intrusiveness. Construct validity and interrater and test‐retest reliability of the Play Scale have been demonstrated. This Play Scale discriminates between children with and without feeding disorders as well as between children with different subtypes of feeding disorders as defined by the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood, Revised (DC:0–3R) (Feeding Disorder of State Regulation, Feeding Disorder of Caregiver‐Infant Reciprocity, and Infantile Anorexia). It can be used for research or clinical practice in the diagnosis and treatment of early feeding problems, to assess the pervasiveness of mother–infant/toddler difficulties and to monitor changes following therapy.     

Mothers' Ideal Positive Affect Predicts their Socialization of Children's Positive Affect

Parents generally want their children to be happy, but little is known about particular types of positive affect (PA) that parents want their children to experience. Tsai's (2007) affect valuation theory offers a useful framework to understand how parents' emotional goals may shape the socialization of particular types of PA (e.g., excitement vs. relaxation). Participants were 96 mothers and their 7- to 12-year-old children. Results indicated that mothers endorsed similar levels of ideal PA (IPA) for low-, moderate-, and high-arousal PA for both themselves and for their child, suggesting that mothers desire the same type of PA for their children as they want for themselves. In support of the study's main hypothesis, mothers' IPA for their children predicted specific socialization responses that would encourage that type of PA (e.g., mothers' high-arousal IPA predicted greater encouragement of their child to celebrate, whereas mothers' low-arousal IPA predicted encouragement of affection). The findings extend affect valuation theory and emotion socialization research by indicating that parents' emotional goals (i.e., IPA) for their children may contribute to their socialization of children's PA.     

L’évaluation cognitive de la lecture au collège : synthèse des principaux outils de dépistage et de diagnostic des troubles spécifiques de la lecture et cognitifs associés

As reported by the Programme for International Student Assessment (PISA, 2012), almost 20% of French teenagers show difficulties in reading (OCDE, 2014). What are the French language tools the practitioner or educationalist (teacher, school doctor, psychologist, and speech-language pathologist) use to assess specific reading disorders for middle school students? The tools assessing reading comprehension skills, word-level reading skills and reading-related skills are presented by distinguishing the tools developed for screening of reading difficulties (the purpose of which is to detect early disease or risk factors for disease in large numbers of apparently healthy individuals) than them developed for diagnosing of reading difficulties (the purpose of which is to establish the presence [or absence] of disease as a basis for treatment decisions in symptomatic or screen positive individuals). This synthesis allows to identify their interests and limits, and to consider new tools respecting five essential criteria: (1) the tool structure must be based on recent theoretical models specific at the middle school, (2) the tool must assess reading comprehension skills (with control of listening comprehension skills) and the mastery of two word-level reading procedures (lexical and sublexical), (3) the tool must measure a set of reading-related skills such as phonological awareness, phonological short-term memory, rapid serial naming and morphological awareness, (4) the experimental material (vocabulary control) and the standardization must be recent or updated and (5) the speed must be measured accurately.     

Computerized Cognitive Tests (CCT) in elderly: A psychometric review

Introduction/aim

Computerized Cognitive Tests (CCT) play an increasing role in the assessment of elderly cognitive impairment. In this framework, it is important to review the psychometric data of the available CCT in the detection of cognitive decline.

Stress scolaire des collégiens et des lycéens : effet de l’appréhension de l’orientation et de la pression de la note

The aim of this study was to test the predictive effect of two variables related to meritocratic ideology and possibly associated with academic stress: academic orientation related worries and apprehension of school evaluation. Differential effects of these variables on stress were also investigated regarding gender and school (middle-high and high schools). Six hundred and nine secondary students completed a questionnaire. Results show that emotional worries regarding academic orientation and apprehension of school evaluation are significant predictors of academic stress. Results reveal differential effects for middle-high school and high school students. In practice, grading and methods used to this aim should be carefully considered as well as the support offered regarding orientation project of middle-high school students especially.     

Reading and related skills in Grades 6, 7, 8 and 9: French normative data from EVALEC

IntroductionTo appropriately assess reading difficulties, tests designed according to an appropriate theoretical framework and based on normative data are required.ObjectiveWe used EVALEC (Sprenger-Charolles, Colé, Béchennec, & Kipffer-Piquard, 2005) to collect data on the word-level reading skills and reading-related skills (phonemic awareness, phonological short-term memory, and rapid naming) of middle school children (Grades 6 to 9, about 80 in each grade).MethodIn the tests focused on word-level reading skills, the effects of regularity (regular vs. irregular words), lexicality, and length (short vs. long irregular words and pseudowords) were examined. Accuracy and processing times were recorded for all tests.ResultsThe effects of both regularity and lexicality were significant, whatever the measure and independently of grade. Both accuracy and speed were lower for longer pseudowords, whereas length did not have a significant effect on irregular word latencies and, surprisingly, long irregular words were read more accurately than short ones. Reading level as assessed by a standardized test (Lefavrais, 2005) was not predicted by phonological short-term memory; rapid naming (color names) and phonemic awareness were both predictors but, in both cases, only response times predicted reading level.ConclusionThese results, and particularly those from the reading tasks, are discussed in relation to models of written-word recognition developed to account for the reading of multisyllabic items (Perry, Ziegler, & Zorzi, 2010) in orthographies shallower than English (Perry, Ziegler, & Zorzi, 2014).     

WISC-IV GAI and CPI profiles in healthy children and children with learning disabilities

IntroductionIn addition to the FSIQ, the General Ability Index (GAI) and the Cognitive Proficiency Index (CPI) are two ancillary scores that can be calculated for the Wechsler Intelligence Scale. The GAI and the CPI have been proposed to assist in identifying cognitive strengths and weaknesses, and thus to provide different views into individual's cognitive abilities.ObjectiveThe purpose of the present study is to provide the frequency of GAI/CPI score difference by direction, the frequency of FSIQ/GAI score difference, and the frequency of FSIQ/CPI score difference, for the French Wechsler Intelligence Scale for Children and Adolescents–Fourth Edition (WISC-IV).MethodThese frequencies are provided for a sample of healthy children (n = 483), and for a sample of children with learning disabilities (LD, n = 370). The GAI comprises verbal comprehension and perceptual reasoning subtests, while CPI comprises working memory and processing speed subtests.ResultsResults indicated that the healthy sample performed better than the LD sample for all composite scores. The FSIQ was lower than the GAI for both groups and this difference was slightly larger for the LD sample (−1.35 points vs. −3.22 points). The GAI was higher than the CPI for both samples, but this difference was not significantly larger for the LD sample (4.2 points vs. 6.16 points). Finally, while the FSIQ was higher than the CPI for both groups, this difference was not larger for the LD sample (2.85 points vs. 2.95 points).ConclusionThese findings support the use of the GAI and the CPI, in addition to the FSIQ.