Quantitative chromatographic profiling of odours associated with dominance in male laboratory mice

Triads of male NMRI mice were housed together and dominance hierarchies allowed to form. At age 19 weeks the mice were ranked on the basis of wins in spontaneous aggressive encounters, and whole-body volatiles were sampled by the dynamic solvent effect and quantitatively analysed by capillary gas chromatography. At age 26 weeks the mice were again ranked on the basis of wins in aggressive encounters, number of aggressive encounters initiated, and scent marking patterns, and whole-body volatiles were sampled and analysed. Chromatographic odour profile ranks agreed perfectly with aggressive initiator ranks and poorly with encounter winner ranks. Eight components of the whole-body odour were identified by gas chromatography-mass spectrometry; two of these are known semiochemicals. The results demonstrate that murine semiochemicals are accessible to quantitative analysis at the level of the individual.     

On normal theory based inference for multilevel models with distributional violations

Data in social and behavioral sciences are often hierarchically organized though seldom normal, yet normal theory based inference procedures are routinely used for analyzing multilevel models. Based on this observation, simple adjustments to normal theory based results are proposed to minimize the consequences of violating normality assumptions. For characterizing the distribution of parameter estimates, sandwich-type covariance matrices are derived. Standard errors based on these covariance matrices remain consistent under distributional violations. Implications of various covariance estimators are also discussed. For evaluating the quality of a multilevel model, a rescaled statistic is given for both the hierarchical linear model and the hierarchical structural equation model. The rescaled statistic, improving the likelihood ratio statistic by estimating one extra parameter, approaches the same mean as its reference distribution. A simulation study with a 2-level factor model implies that the rescaled statistic is preferable.This research was supported by grants DA01070 and DA00017 from the National Institute on Drug Abuse and a University of North Texas faculty research grant. We would like to thank the Associate Editor and two reviewers for suggestions that helped to improve the paper.     

Practice effects on speech production planning: evidence from slips of the tongue in spontaneous vs. preplanned speech in Japanese

The present study addresses the question of how practice in expressing the content to be conveyed in a specific situation influences speech production planning processes. A comparison of slips of the tongue in Japanese collected from spontaneous everyday conversation and those collected from largely preplanned conversation in live-broadcast TV programs reveals that, although there are those aspects of speech production planning that are unaffected by practice, there are various practice effects, most of which can be explained in terms of automatization of the processing of content, resulting in shifts in the loci of errors.     

共享概念的性质对拥有关系句子情景模型建立的影响

应用扇效应技术探讨共享概念的性质对建构拥有关系情境模型的影响。共包括2个实验,探讨在将“多人买1物”句式中的所购“物品”改变为隐含共同地点信息的“物品”条件下,被试对“多人买1物”拥有行为句式的学习是否表现出扇效应。结果表明,当所购物品隐含的相同地点信息的情况下,“多人买1物”的拥有行为句式无论是否具有明确的地点状语,都如同“1人买多物”的句式一样,没有表现出扇效应,与Radvanskv的研究结果不同。据此认为,只有在共享概念是属于情景模型建构的维度信息的情况下,有共享概念的信息才能整合为同一个情景模型。     

Fabry disease in genetic counseling practice: recommendations of the National Society of Genetic Counselors

The objective of this document is to provide health care professionals with recommendations for genetic counseling and testing of individuals with a suspected or confirmed diagnosis of Fabry disease, with a family history of Fabry disease, and those identified as female carriers of Fabry disease. These recommendations are the opinions of a multicenter working group of genetic counselors, medical geneticists, and other health professionals with expertise in Fabry disease counseling, as well as an individual with Fabry disease who is a founder of a Fabry disease patient advocacy group in the United States. The recommendations are U.S. Preventive Task Force Class III, and they are based on clinical experience, a review of pertinent English-language articles, and reports of expert committees. This document reviews the genetics of Fabry disease, the indications for genetic testing and interpretation of results, psychosocial considerations, and references for professional and patient resources. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a healthcare provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.     

The Good Behavior Game: a best practice candidate as a universal behavioral vaccine

A behavioral vaccine provides an inoculation against morbidity or mortality, impacting physical, mental, or behavior disorders. An historical example of a behavioral vaccine is antiseptic hand washing to reduce childbed fever. In current society, issues with high levels of morbidity, such as substance abuse, delinquency, youth violence, and other behavioral disorders (multiproblems), cry out for a low-cost, widespread strategy as simple as antiseptic hand washing. Congruent research findings from longitudinal studies, twin studies, and other investigations suggest that a possibility might exist for a behavioral vaccine for multiproblem behavior. A simple behavioral strategy called the Good Behavior Game (GBG), which reinforces inhibition in a group context of elementary school, has substantial previous research to consider its use as a behavioral vaccine. The GBG is not a curriculum but rather a simple behavioral procedure from applied behavior analysis. Approximately 20 independent replications of the GBG across different grade levels, different types of students, different settings, and some with long-term follow-up show strong, consistent impact on impulsive, disruptive behaviors of children and teens as well as reductions in substance use or serious antisocial behaviors. The GBG, named as a best practice for the prevention of substance abuse or violent behavior by a number of federal agencies, is unique because it is the only practice implemented by individual teachers that is documented to have long-term effects. Presently, the GBG is only used in a small number of settings. However, near universal use of the GBG, in major political jurisdictions during the elementary years, could substantially reduce the incidence of substance use, antisocial behavior, and other adverse developmental or social consequences at a very modest cost, with very positive cost-effectiveness ratios.     

Conflict of interest: the importance of potential

The UK Medical Research Council (MRC) takes the issue of conflict of interest very seriously. The overall aim is to preserve a climate in which personal and organisational innovation can flourish while ensuring that potential conflicts are disclosed and identified and conflicts are either avoided or managed with integrity. The approach needs to encompass the MRC’s various responsibilities and the levels at which conflicts might arise: MRC staff (scientists and administrators); the governing Council; research Boards and committees; external peer-reviewers; and applicants for funding. To achieve its goals, the MRC has issued practical guidance on various aspects of conflict of interest. For the future, the MRC has identified the continuing commercialisation of science and the increasing involvement of lay people in scientific decision-making as special challenges in this area. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

中国大学生的记忆的自我参照效应

记忆的自我参照效应是指记忆材料与自我相联系时的记忆效果优于其它编码条件的现象,这种优势主要体现在以回忆经验为特征的R反应(“记得”)上。西方一些研究表明,自我参照的记忆成绩优于参照母亲的记忆。本研究以中国大学生为被试,得到参照父亲和母亲的记忆与自我参照有同样好的成绩,显著优于参照名人的记忆,并且父母之间无差异。这支持了独立型／依赖型自我概念模型中的东方文化下的自我概念包括父母的观点。