Disrupted memory inhibition in dementia of Alzheimer’s type

Cognitive inhibition has been suggested to deteriorate in Alzheimer’s disease. While numerous studies with different experimental paradigms found evidence on impaired inhibition in attention and memory, evidence in favour of intact memory inhibition has been reported with regard to the phenomenon of retrieval-induced forgetting (Moulin et al., 2002). Here, we adapted the previously used paradigm in order to reduce the contribution of non-inhibitory processes and examined whether retrieval-induced forgetting could still be observed in a sample of participants with diagnosed Alzheimer’s disease. In contrast to the previous finding, we found that retrieval-induced forgetting only occurred in an age-matched control group. These results suggest that inhibitory deficits in Alzheimer’s disease also generalize to memory inhibition that resolves interference occurring during retrieval, whereas effects of retrieval-induced forgetting may still occur when non-inhibitory causes, such as, blocking by previously retrieved content, are not precluded.     

The neural pathways mediating quiet-biting attack behavior from the hypothalamus in the cat: A functional autoradiographic study

Electrical stimulation of the region of the lateral hypothalamus produced a consistent form of quiet-biting attack behavior in cats. In one series of experiments, cats, implanted with electrodes from which attack had been elicited, were anesthetized and then were injected with a bolus of ¹⁴C-2-deoxyglucose at the same time as electrical stimulation was delivered through the attack electrodes. Brains prepared for X-ray autoradiography revealed that lateral hypothalamic stimulation activated the classical medial forebrain bundle pathway supplying the septal region, diagonal band, lateral preoptic area, and ventral tegmental region. Stimulation of quiet-attack sites in perifornical hypothalamus resulted in the activation of a much more extensive projection system which included the central and lateral tegmental fields of the midbrain and pons, and central gray region, as well as the structures described above. In a second series of experiments, ³H-leucine was placed into the region of the electrode tip from which attack was elicited in order to identify more precisely the pathways arising from that site. In general, tritiated amino acid radioautography replicated the ¹⁴C-2-deoxyglucose findings. In addition, the amino acid radioautographic data revealed the presence of extensive projections from perifornical hypothalamus to such pontine structures as the nucleus locus coeruleus, motor nucleus of NV , and the lateral pontine tegmental field. The functional connections between the lateral hypothalamic “attack region” and lateral preoptic zone were also confirmed by electrophysiological methods.     

Behavioral changes over several successful agonistic encounters between male mice: Effects of type of “standard opponent”

This study assessed whether two types of non-aggressive “standard opponents” (“intact” and “anosmic” group-housed males) produced similar behavioral changes in isolated OF1 male mice given several experiences of victory. Experimental groups confronted either intact or anosmic opponents every two days until they had completed four encounters. The behavioral changes were recorded using a detailed ethologically inspired analysis. These changes were clearly different depending on the opponent type. When intact opponents were used, experimental subjects increased the time spent in digging, non-social exploration, explore from a distance, and attack over encounters, but showed decreased time spent in threat and a decreased latency to the first attack. In encounters with anosmic opponents, only declines in the latencies to threat and attack were noted. Moreover, the experimental groups differed in their behaviors over encounters. Those confronting intact opponents spent less time in social investigation, more time in explore from a distance and threat, and showed a shorter latencies to threat and attack than counterparts confronting anosmics. These results suggest that, although both types of “standard opponents” are similar in their non-aggressiveness, they elicit rather different behavioral responses in their adversaries. These findings provide additional support for the view that the type of opponent used in studies on intermale aggression is of paramount importance. Indeed, the use of different types of “standardized non-aggressive opponents” appears to be an important source of variability between studies. © 1994 Wiley-Liss, Inc.     

Assessment to identify learner-specific prompt and prompt-fading procedures for children with autism spectrum disorder

Few studies have evaluated the use of assessment to identify the most efficient instructional practices for individuals with autism spectrum disorder. This is problematic as these individuals often have difficulty acquiring skills, and the procedures that may be efficient with one individual may not be for others. The experimenters conducted instructional assessments to identify the most efficient prompt type (model, partial physical, full physical) and prompt-fading procedure (progressive delay, most-to-least, least-to-most) for teaching auditory–visual conditional discriminations for individuals with autism spectrum disorder. Each assessment was conducted at least twice, and a final generality test combined the most and the least efficient prompt type and prompt-fading procedure for teaching novel auditory–visual conditional discriminations. The results demonstrated learner-specific outcomes for the prompt type assessment, whereas the least-to-most prompt fading procedure was most efficient for all participants.     

急性应激损害对威胁刺激的注意解除

急性应激会增强个体对威胁刺激的注意偏向, 但急性应激是增强了对威胁刺激的注意定向还是损害了对威胁刺激的注意解除还不清楚。本研究采用社会评估冷压任务和点探测任务, 结合事件相关电位技术, 考察急性应激对威胁刺激注意偏向影响的认知机制。在进行社会评估冷压任务后, 应激组个体的状态焦虑和皮质醇浓度显著升高。在注意偏向中, 应激组对威胁刺激的注意解除比控制组更慢, 应激组和控制组在对威胁刺激的注意定向上无显著差异。ERP结果上, 威胁刺激诱发应激组比控制组产生了更负的SPCN, 在N2pc上没有显著差异。应激组和控制组皮质醇增量的差异和N2pc、SPCN的组间差异均有显著正相关。这些结果说明, 急性应激增强对威胁刺激的注意偏向是因为其损害个体对威胁刺激的注意解除, 这可能是因为急性应激损害了与注意解除相关的额-顶网络的功能所致。     

语言熟练度对Stroop效应的影响——不平衡双语者的任务态fMRI研究

目的:探讨语言熟练度对Stroop效应的影响及其背后的脑机制。材料与方法:17位被试参与本研究。被试母语为汉语,第二语言为英语。在被试完成中英文的stroop色字的任务过程中对被试进行fMRI扫描。结果:在色字相一致的条件下,中文任务与英文任务相比,双侧背侧枕叶及右侧背外侧前额叶有更强的激活; 反向比较,双侧腹侧枕叶有更强的激活。在色字不一致的条件下,中文任务与英文任务相比,双侧背外侧前额叶、右侧枕下回有更强的激活; 反向比较,并无显著激活的脑区。此外,中文Stroop效应引起左侧额下回显著的激活。英文Stroop效应中,左侧额下回无显著激活。结论:结合前人研究,我们得出,语言熟练度影响了对注意控制有重要作用的背外侧前额叶以及与反应抑制有关的左侧额下回在Stroop任务中的参与程度,进而影响了Stroop任务的表现     

Human factors evaluation of an in-vehicle active traffic and demand management (ATDM) system

This research study focused on the evaluation of an emulated in-vehicle Active Traffic and Demand Management (ATDM) system on Interstate 66 in Northern Virginia. Traditional ATDM systems rely on infrastructure-mounted variable message signs (VMS) to provide information (speed limits, lane availability, etc.) to the traveling public. By providing information about dynamic roadway conditions on an in-vehicle device, the ATDM may improve driving safety and performance by allowing drivers to remain consistently aware of forthcoming traffic conditions and roadway requirements; even when external signage is inaccessible. This study represents an initial investigation of an emulated in-vehicle ATDM to provide developers with design guidance and ensure that unintended consequences, such as distraction, do not undermine the potential benefits.Twenty younger and 20 older participants, accompanied by a member of the research team, experienced the following ATDM features on an in-vehicle device (IVD) mounted to the dashboard: (1) dynamic speed limits, (2) dynamic lane use/shoulder control, (3) High Occupancy Vehicle (HOV) restrictions, and (4) roadway information from variable message signs. The IVD was equipped with auditory and visual alerts notifying the driver when relevant visual information was updated. Research questions addressed distraction and driver behavior associated with use of the system. Qualitative and quantitative participant data was acquired from the instrumented vehicle, various questionnaires, and researcher observation.Several key findings were uncovered: (1) The IVD, as tested, did not warrant classification as a source of distraction according to the NHTSA guidelines; v2) There was a significant difference in eye-glance durations to the IVD when comparing the VMS alerts to both the speed limit and lane management alerts; and (3) The speed limit alert motivated participants to alter their speed (per survey results and participant speed data).     

Cyclist strategies and behaviour at intersections. Conscious and un-conscious strategies regarding positioning

Severe and even fatal accidents between cyclists and motor vehicles commonly occur at intersections. Many of these accidents occur with right-turning vehicles, with drivers not observing an adjacent cyclist. Few structured investigations exist regarding the interaction between cyclist and motor vehicle, and factors in need of study are how infrastructure and vehicle properties affect human decision-making and cycling behaviour. Therefore, a bicycle simulator study was performed, where vehicle type, presence of lane markings and lane width were systematically varied in a scenario with a cyclist approaching a vehicle from behind, at a signalized city intersection. 33 participants cycled through 8 intersection variants each. Data on cycling trajectories, stopping points and speed was coupled with survey data from the participants, and semantically categorized verbal responses to questions regarding strategy for choice of stopping point. Results show that all three factors (vehicle type, lane markings and available vehicle-adjacent space) significantly affects cyclists’ behaviour and conscious strategies. Participants were more cautious in the presence of a truck than a car, reflected in choice of position when cycling and stopping, and in explicit verbalisations regarding perilous aspects of the situation and their conscious and strategic choice of positioning. Available lateral space also affected stop positions and feeling of safety (expressed verbally). Presence of bicycle lane markings made the cyclists inclined to continue into the space to the right of the vehicle. This was revealed by their positioning and speed, and also apparent in the verbal expressions, especially the positive remarks on the situation and conditions. However, the perceived comfort with lane markings present was actually lower than when they were missing. Cyclist type (slow, moderate, or fast) matters with the self-reported faster cyclists being more prone to stop to the right than the slower one.     

Using the UTAUT2 model to explain public acceptance of conditionally automated (L3) cars: A questionnaire study among 9,118 car drivers from eight European countries

We investigated public acceptance of conditionally automated (SAE Level 3) passenger cars using a questionnaire study among 9,118 car-drivers in eight European countries, as part of the European L3Pilot project. 71.06% of respondents considered conditionally automated cars easy to use while 28.03% of respondents planned to buy a conditionally automated car once it is available. 41.85% of respondents would like to use the time in the conditionally automated car for secondary activities. Among these 41.85%, respondents plan to talk to fellow travellers (44.76%), surf the internet, watch videos or TV shows (44%), observe the landscape (41.70%), and work (17.06%). The UTAUT2 (Unified Theory of Acceptance and Use of Technology) was applied to investigate the effects of performance and effort expectancy, social influence, facilitating conditions, and hedonic motivation on the behavioural intention to use conditionally automated cars. Structural equation analysis revealed that the UTAUT2 can be applied to conditional automation, with hedonic motivation, social influence, and performance expectancy influencing the behavioural intention to buy and use a conditionally automated car. The present study also found positive effects of facilitating conditions on effort expectancy and hedonic motivation. Social influence was a positive predictor of hedonic motivation, facilitating conditions, and performance expectancy. Age, gender and experience with advanced driver assistance systems had significant, yet small (<0.10), effects on behavioural intention. The implications of these results on the policy and best practices to enable large-scale implementation of conditionally automated cars on public roads are discussed.     

人名发音与脸型的跨模态映射效应

摘要:本文基于无意义词与简单几何体之间的跨模态映射效应,来研究社会知觉中人名发音与脸型的关系。本研究控制了人名发音的唇形和人物面孔的轮廓,通过简单匹配范式来考察人名发音与面孔之间是否存在跨模态映射效应。结果发现：被试将圆唇人名与圆面孔匹配、扁唇人名与尖面孔匹配的概率,均显著大于随机水平。该结果说明了人名发音和脸型之间存在跨模态映射效应,这不仅拓宽了声音-形状跨模态映射的研究范围,对于人们取名字方面具有一定的指导意义。