从胰腺移植到胰岛干细胞移植

糖尿病学家在胰腺及胰岛细胞移植领域进行了不懈的探索。胰腺移植和胰岛细胞移植的两大制约因素是可供移植的胰腺来源少且诱发受体免疫排斥反应而需应用免疫抑制剂。胰岛细胞制备、纯化技术以及免疫隔离技术的应用在一定程度上克服了上述两大制约因素，人们期待胰岛干细胞技术及其相关的基因技术的深入将这一技术趋于完善。     

Association between cognitive vulnerability to depression - dysfunctional attitudes and glycaemic control among in-patients with type 2 diabetes in a hospital in Beijing: a multivariate regression analysis

This cross-sectional study aimed to investigate the relationship between glycosylated haemoglobin (HbA1c) and cognitive vulnerability to depression (dysfunctional attitudes) in patients with type 2 diabetes mellitus. A total of 245 valid records from June 2016 to December 2016 were collected from a hospital in Beijing. Participants were asked to complete four questionnaires (Dysfunctional Attitudes Scale, Automatic Thoughts Questionnaire, Zung Self-rating Depression Scale, and World Health Organization Quality of Life Instrument-Short Form) to assess mental health and quality of life. Multivariate regression analysis was conducted to determine the correlations between HbA1c, mental health, quality of life and other clinical variables. The results showed that dysfunctional attitudes were associated with HbA1c, with a standardized regression coefficient (β) of .13 (p = .01), although 1 h C-peptide (β = ?.75, p < .0001) was the most significant predictor of HbA1c in the regression model. The results indicated that dysfunctional attitudes, as a cognitive vulnerability to depression, were a relevant factor in HbA1c, although further studies are needed to establish the nature of the connection between dysfunctional attitudes and glycaemic control in diabetes patients.     

Cyclist efficiency and its dependence on infrastructure and usual speed

Bicyclists are a heterogeneous group, with varying abilities, traffic education and experience. While efficiency was identified as an important factor on utility bicycle trips, it might be traded for experienced safety, for example by choosing different pathways in a given situation, or by relinquishing one’s right of way. In a semi-controlled study with 41 participants, a grouping was made according to self-reported riding speed in relation to other cyclists. The participants cycled twice along a 3 km inner-city route, passing four intersections with different priority rules. The cyclists were free to choose how to negotiate the intersections. Speed and the traffic surroundings were recorded via gps and cameras on the bike of the participant and of a following experimenter. For each cyclist, the ‘base’ speed on undisturbed segments was determined as reference. Based on this, the efficiency in different types of intersections was computed per cyclist group. It turned out that infrastructural aspects, cyclist group and the presence and behaviour of interacting traffic influenced cyclist efficiency. Faster cyclists were delayed more when the infrastructure required a stop regardless of the traffic situation, like at a red traffic light or a stop sign. The members of the so-called ‘comfort cyclists’ group were delayed the most in a roundabout with mixed traffic, where many chose to get off their bike and walk. In a society working for equality of access to the transport system, it is recommended to develop solutions that consider and accommodate the behaviours of different cyclist groups when planning bicycling infrastructure.     

Life stories managing chronic illness: Young adults’ lived experiences with type 1 diabetes

This study aimed to characterise diabetes management experiences of South African young adults living with well-controlled type 1 diabetes (n = 8, female = 5, male = 3, age range = 20–25). The young adults told life stories managing their type 1 diabetes. Thematic analysis revealed the young adults to construct personal identities as people living with type 1 diabetes, to mostly utilise emotion-focused management strategies and social support for successful living with type 1 diabetes. Behavioural health strategies appear important for living well with this chronic insulin deficiency condition.     

肠促胰素对2型糖尿病胰岛功能的影响

胰岛β细胞功能障碍是2型糖尿病的重要发病机制之一,而现有治疗手段保护β细胞功能作用有限。最新的研究发现,肠促胰素不仅能够改善口细胞功能,而且能够避免低血糖、体重增加等不良反应,是治疗2型糖尿病的新途径。本文通过回顾公开发表的临床研究,对2型糖尿病口细胞功能、传统治疗及肠促胰素对β细胞功能的保护及延缓疾病进展作用进行了综...     

糖尿病与睡眠的相互关系

人一生中有1／3的时间在睡眠中度过,睡眠质量直接关系到一个人的身体健康。睡眠时间过少或过多的人糖尿病患病率大大增加。糖尿病本身的病理、生理特点,严重影响患者的睡眠质量,睡眠质量又可以反过来影响糖尿病患者的血糖水平。有研究显示,糖尿病患者最佳睡眠时间为8小时。同时糖尿病患者中睡眠呼吸暂停综合征（OSAS）患病率高,0SA...     

Partial Monotonic Protothetics

This paper has four parts. In the first part, I present Leniewski's protothetics and the complete system provided for that logic by Henkin. The second part presents a generalized notion of partial functions in propositional type theory. In the third part, these partial functions are used to define partial interpretations for protothetics. Finally, I present in the fourth part a complete system for partial protothetics. Completeness is proved by Henkin's method [4] using saturated sets instead of maximally saturated sets. This technique provides a canonical representation of a partial semantic space and it is suggested that this space can be interpreted as an epistemic state of a non-omniscient agent.