对肿瘤研究的思考：观测与结果

从哲学的角度,对肿瘤研究中的常用方法即观测与测定进行了理性的思考,探讨理论背景、观测仪器和测量过程对观测和测量的结果存在影响,肿瘤发生机理的基因异常理论的片面性,提出肿瘤发生的非平衡自组织观点、亚细胞水平成分测不准的可能性和肿瘤细胞及机体研究的黑箱方法。     

生物自组织临界性与肿瘤

分析了局部组织由再生、化生和癌变呈现的各种宏观行为和性质,从生物自组织临界性的角度讨论了这类行为和性质的演化模式及机制,指出肿瘤实质是局部组织经历一系列临界状态下相变造成的。     

Parent reports of children’s working memory,coping, and emotional/behavioral adjustment in pediatric brain tumor patients: A pilot study

Neurocognitive problems in childhood survivors of brain tumors are well documented. Further, research has shown that problems in cognitive functioning may be associated with impairment in the use of complex strategies needed to cope with stress, including secondary control coping strategies (e.g., acceptance and cognitive reappraisal) which have been associated with fewer adjustment problems. The present study measured cognitive function, coping strategies, and adjustment in children ages 6–16 years at the time of brain tumor diagnosis and at two follow-up time-points up to 1 year post-diagnosis. In a prospective design, working memory was assessed in a total of 29 pediatric brain tumor patients prior to undergoing surgery, child self-reported coping was assessed at 6 months post-diagnosis, and parent-reported child adjustment was assessed at 12 months post-diagnosis. Significant correlations were found between working memory difficulties and secondary control coping. Secondary control coping was also negatively correlated with child attention and total problems. Regression analyses did not support secondary control coping mediating the association between working memory difficulties and child attention or total problems. These findings represent the first longitudinal assessment of the association between working memory, coping, and adjustment across the first year of a child’s brain tumor diagnosis and suggest a possible role for early interventions addressing both working memory difficulties and coping in children with brain tumors.     

Sex,germs, and health: pathogen-avoidance motives and health-protective behaviour

Objective: Recent work suggests that the psychology of pathogen-avoidance has wide-reaching effects on how people interact with the world. These processes – part of what has been referred to as the behavioural immune system – are, in a way, our ‘evolved’ health psychology. However, scholars have scarcely investigated how the behavioural immune system relates to health-protective behaviours. The current research attempts to fill this gap.

Design: Across two cross-sectional studies (N = 386 and 470, respectively), we examined the relationship between pathogen-avoidance motives and health-protective behaviour.

Outcome Measures: The studies used self-reported measures of attitude and intention as indicators of health-protective behaviour.

Results: Data collected in Study 1 revealed that pathogen-avoidance motivation related to participants’ attitude and intention towards sexually transmitted infections screening. High levels of pathogen-avoidance motivation were also related to having had fewer sexual partners, which partially mediated the effect of pathogen-avoidance variables on testing motivation. Study 2 extended these findings by showing moderate associations between pathogen-avoidance motivation and a broad range of health-protective behaviours, including but not limited to pathogen-related health concerns.

Conclusion: We argue that understanding and targeting pathogen-avoidance psychology can add novel and important understanding of health-protective behaviour.     

肿瘤抗原与肿瘤免疫

通过自身的免疫系统对肿瘤细胞进行杀灭已成为极具潜力的抗肿瘤手段。肿瘤抗原与机体对肿瘤细胞的免疫之间形成了一个此消彼长的矛盾关系,研究肿瘤研究自身的免疫学特性以及肿瘤细胞的免疫原性之间相互关系的问题已成为当前研究中的热点。一方面,可利用增强肿瘤细胞的抗原性来增强机体的免疫排斥反应;另一方面,纠正机体免疫系统的功能障碍,以增强其刺激免疫应答的能力,并辨证地分析了这两方面在肿瘤免疫排斥中的作用及相应的解决对策。     

关于复治肺结核若干问题的讨论

通过对复治肺结核相关概念的分析探讨,结合临床实际,认为正确认识复活肺结核的概念是治疗复治肺结核的前提,不同复治肺结核病人应采取不同的化疗方案;并根据人类认识结核病的历史、人体免疫系统特点及免疫治疗的必要性,指出不应忽视免疫在复治肺结核治疗中的作用。只有改善机体的内外环境,提高机体的免疫防御功能,才能从根本上防治结核。     

促排卵治疗及其风险的探讨

促排卵药物在临床中的广泛应用,给不孕患者带来了希望,另一方面促排卵带来的风险也越来越引起人们的重视,如卵巢过度刺激综合征(OHSS)、妊娠并发症、出生缺陷和肿瘤等。因此,用哲学的观点客观地看待促排卵的成效与风险之间的关系有助于临床医生进一步提高促排卵安全性的认识,做出正确的决策。     

卵巢肿瘤蒂扭转误诊、漏诊分析

回顾性分析了我院10年间17例卵巢肿瘤蒂扭转病例,并从患者年龄、临床表现、辅助检查、治疗情况等方面对误诊、漏诊的原因进行了分析。发生在青少年、儿童的卵巢肿瘤蒂扭转误诊率为52．9％,发生在绝经后妇女者误诊率为29．4％,最易误诊为急性阑尾炎,临床医生应予以高度重视。     

对免疫系统非优性的探讨

免疫系统是维持机体自身稳定的一个重要系统。从系统的功能、环境和信息方面阐述免疫系统优与非优的表现和关系;并提出由于免疫系统存在非优信息的特点,科研人员在对免疫系统认识过程中应客观、全面,在认识事物优的同时也应看到事物非优的一面。     

阴式手术在卵巢良性肿瘤手术中的地位

为了探讨阴式手术在卵巢良性肿瘤手术中的重要性,通过回顾性分析解放军总医院2003年～2006年间收治的卵巢良性肿瘤患者60例(阴式、腹腔镜、开腹手术各20例),对3种术式的手术时间、术中出血量、术后病率、术后肛门排气时间、住院时间进行比较,进而拓展到我院多种疑难阴式手术情况和结局。结果显示,对于卵巢良性肿瘤,阴式组手术时间短,恢复快,术后病率少。提示阴式手术在卵巢良性肿瘤手术中居于非常重要的地位。