系统论方法在糖尿病性视网膜病变危险因素及治疗研究中的应用

全球糖尿病患者人数在不断的增多,大约10％的Ⅰ型糖尿病患者在10年后可出现糖尿病性视网膜病变,而大约95％的Ⅱ型糖尿病患者在20年后可出现糖尿病性视网膜病变。目前,糖尿病性视网膜病的发病机制尚不明确,影响其发生发展的因素也很复杂,因此,对糖尿病性视网膜病的发病危险因素及其诊治的研究,具有相当重要的意义。系统论,研究各种物质运动形态所共有的系统联系和关系,具有普遍的方法论意义,为现代医学的进步提供了全新的思维方式和科学方法论原则。本文试用系统论的整体性、优化原理阐述糖尿病性视网膜病变发病的危险因素与治疗进展,为对其深入研究提供方法论依据。     

非小细胞肺癌靶向治疗的前途与困惑

靶向治疗是运用抗肿瘤药物靶向性与肿瘤的不同特异性住点结合发生作用从而抑制肿瘤细胞生长的一种治疗手段。针对恶性肿瘤中的非小细胞肺癌,其在临床中取得了一定成效。然而,其中仍存在很多问题。本文针对吉非替尼在非小细胞肺癌中的运用,及其优点和所面临的问题,阐述如何应对完善靶向治疗的挑战。     

乳腺癌诊治过程中的多学科协作

乳腺癌是全身疾病,其治疗和诊断都需要多个学科的积极参与协作才能完成。本文就自身体会认为乳腺专科医生掌握诸如肿瘤外科技术与肿瘤内科治疗措施,熟悉乳腺癌放疗与美容整形的相关技术,并能掌握诸如乳腺B超等检查手段等多个学科知识,同时和病理等相关科室紧密协作,是处理好乳腺癌诊治过程中的多学科协作问题的一种有效方法。     

惊恐障碍药物心理干预的临床动态研究

惊恐障碍（panic disorder,PD）是综合医院常见的一种急性焦虑障碍,严重地影响患者的精神心理健康、社会功能和生活质量,并造成医疗资源的极大浪费。本研究通过动态比较药物与药物加心理治疗的疗效,为更合理的对惊恐障碍进行临床干预提供了一定决策依据。     

子宫内膜癌患者治疗方式的选择

子宫内膜癌是女性生殖道常见的恶性肿瘤之一,其主要的治疗手段是手术,传统的治疗术式将双侧卵巢一并切除。随着医学模式的转变,现代医学提出了新的观点一保留卵巢功能,但是卵巢保留有其风险性和安全性,这就要求选择保留卵巢时要慎重。     

一种全面的、细化的治疗皮肤病思路的探索

传统的疾病治疗思路或模式显得相对单一和笼统。全面的、细化的疾病治疗应包括病因治疗、病机治疗、症状治疗、体征治疗和指标治疗五个方面。以湿疹和寻常型银屑病的治疗为例介绍全面的、细化的治疗皮肤病思路,期望这一思路能得到他人的认可和推广。     

诱导2型糖尿病的“蜜月期”——治疗糖尿病的新策略

在2型糖尿病β细胞功能早期失代偿阶段,通过短期治疗,可以逆转或改善其功能,从而获得病情的长期缓解,称为2型糖尿病的“蜜月期”。本文就2型糖尿病的“蜜月期”的病理生理基础、影响因素、诱导措施等进行分析,探索2型糖尿病治疗的新策略。     

整形美容外科的实践认识和选择性治疗的哲学应用

随着我国经济、生活条件的改善,现代整形美容技术飞速发展给广大有身体缺欠者提供了机会,同时也给临床工作者带来了很多问题。因此对整形美容外科实践进行哲学思考,进行选择性治疗,遵守客观规律,既有利于满足医患双方的利益,缓解医患关系,减少医疗纠纷的发生,又有利于提高整形美容外科的整体医疗服务质量。     

Neuropsychological Functioning and Antiretroviral Treatment in HIV/AIDS: A Review

This article presents a review of studies that have investigated the neuropsychological effects of antiretroviral treatment (ART) for HIV-1 infection. It provides a brief overview of the era of monotherapy, dual-therapy, and an extended overview of the current era of combination antiretroviral therapy (CART). This review highlights that while CART has had a dramatic effect on the incidence and the severity of HIV-associated neurocognitive disorders (HAND), HAND, in its mild form, still remains prevalent. New causes of this sustained prevalence are poor CNS penetration of some antiretroviral agents, drug resistance, poor adherence, potential neurotoxicity, co-morbidities such as the long-term CART side effects in relation to cardio-vascular disease, and chronic HIV brain infection that may facilitate the expression of new forms of neurodegenerative processes. The review emphasizes the need to address methodological limitations of published studies and the need for large and representative cross-disciplinary longitudinal investigations across the HIV illness span.     

Patterns of Conflict Interaction in Mother–Toddler Dyads: Differences Between Depressed and Non-depressed Mothers

We examined the differences in conflict interaction between depressed mothers and their toddler and non-depressed dyads and whether these differences mediated the association of maternal depression with compromised child socioemotional development. Mother/child interaction was videotaped during a teaching task and during a free play task as part of a home visit when the target child was between 16 and 18 months old. Each turn of every conflict was coded for behavior and affect of each member of the dyad. Interaction data were summarized to calculate the number of conflict turns, the rate of conflict, and the proportion of mother-initiated versus child-initiated conflicts per dyad. Sequential analysis was used to estimate the probability of specific maternal responses to specific child behaviors. Bivariate comparisons indicated that depressed dyads experienced higher rates of conflict, especially during the teaching task, and that depressed mothers were more likely to respond destructively to child oppositional behavior. Results of multivariate linear regression indicated that the higher probability of destructive response mediated the association of maternal depression with lower quality of mother–child attachment. These findings have implications for the development of interventions to support mothers in dealing with the conflicts that are so common during the second year of a child’s life.